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Items: 1 to 50 of 56

1.

Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP).

Albekairi TH, Vaidya B, Patel R, Nozohouri S, Villalba H, Zhang Y, Lee YS, Al-Ahmad A, Abbruscato TJ.

Pharmaceutics. 2019 Sep 10;11(9). pii: E467. doi: 10.3390/pharmaceutics11090467.

2.

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.

Jayaraman S, Al Shoyaib A, Kocot J, Villalba H, Alamri FF, Rashid M, Wangler NJ, Chowdhury EA, German N, Arumugam TV, Abbruscato TJ, Karamyan VT.

J Neurochem. 2019 Sep 5. doi: 10.1111/jnc.14864. [Epub ahead of print]

PMID:
31486527
3.

Neurovascular unit transport responses to ischemia and common coexisting conditions: smoking and diabetes.

Sifat AE, Vaidya B, Villalba H, Albekairi TH, Abbruscato TJ.

Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C2-C15. doi: 10.1152/ajpcell.00187.2018. Epub 2018 Sep 12. Review.

PMID:
30207783
4.

Potential role of myo-inositol to improve ischemic stroke outcome in diabetic mouse.

Villalba H, Shah K, Albekairi TH, Sifat AE, Vaidya B, Abbruscato TJ.

Brain Res. 2018 Nov 15;1699:166-176. doi: 10.1016/j.brainres.2018.08.028. Epub 2018 Aug 27.

PMID:
30165043
5.

Nicotine and electronic cigarette (E-Cig) exposure decreases brain glucose utilization in ischemic stroke.

Sifat AE, Vaidya B, Kaisar MA, Cucullo L, Abbruscato TJ.

J Neurochem. 2018 Oct;147(2):204-221. doi: 10.1111/jnc.14561. Epub 2018 Oct 18.

6.

DARK Classics in Chemical Neuroscience: Methamphetamine.

Abbruscato TJ, Trippier PC.

ACS Chem Neurosci. 2018 Oct 17;9(10):2373-2378. doi: 10.1021/acschemneuro.8b00123. Epub 2018 Apr 6.

PMID:
29602278
7.

The neuroprotective role of the brain opioid system in stroke injury.

Vaidya B, Sifat AE, Karamyan VT, Abbruscato TJ.

Drug Discov Today. 2018 Jul;23(7):1385-1395. doi: 10.1016/j.drudis.2018.02.011. Epub 2018 Mar 1. Review.

PMID:
29501910
8.

Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?

Kaisar MA, Villalba H, Prasad S, Liles T, Sifat AE, Sajja RK, Abbruscato TJ, Cucullo L.

Redox Biol. 2017 Oct;13:353-362. doi: 10.1016/j.redox.2017.06.006. Epub 2017 Jun 17.

9.

Blood-Brain Barrier Protection as a Therapeutic Strategy for Acute Ischemic Stroke.

Sifat AE, Vaidya B, Abbruscato TJ.

AAPS J. 2017 Jul;19(4):957-972. doi: 10.1208/s12248-017-0091-7. Epub 2017 May 8. Review.

PMID:
28484963
10.

Passage Variation of PC12 Cells Results in Inconsistent Susceptibility to Externally Induced Apoptosis.

Kinarivala N, Shah K, Abbruscato TJ, Trippier PC.

ACS Chem Neurosci. 2017 Jan 18;8(1):82-88. doi: 10.1021/acschemneuro.6b00208. Epub 2016 Oct 20.

11.

Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment.

Islam MR, Yang L, Lee YS, Hruby VJ, Karamyan VT, Abbruscato TJ.

Curr Pharm Des. 2016;22(42):6459-6468. doi: 10.2174/1381612822666160720170124.

PMID:
27510489
12.

Preparation and preliminary characterization of recombinant neurolysin for in vivo studies.

Wangler NJ, Jayaraman S, Zhu R, Mechref Y, Abbruscato TJ, Bickel U, Karamyan VT.

J Biotechnol. 2016 Sep 20;234:105-115. doi: 10.1016/j.jbiotec.2016.07.007. Epub 2016 Aug 2.

PMID:
27496565
13.

Peptides at the blood brain barrier: Knowing me knowing you.

Davis TP, Abbruscato TJ, Egleton RD.

Peptides. 2015 Oct;72:50-6. doi: 10.1016/j.peptides.2015.04.020. Epub 2015 Apr 30. Review.

14.

Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice.

Shah KK, Boreddy PR, Abbruscato TJ.

Fluids Barriers CNS. 2015 Apr 29;12:10. doi: 10.1186/s12987-015-0005-y.

15.

In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.

Yang L, Islam MR, Karamyan VT, Abbruscato TJ.

Brain Res. 2015 Jun 3;1609:1-11. doi: 10.1016/j.brainres.2015.03.022. Epub 2015 Mar 20.

16.

Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain.

Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscato TJ, Karamyan VT.

J Neurochem. 2014 Apr;129(1):179-89. doi: 10.1111/jnc.12513. Epub 2013 Nov 19.

17.

An in vitro model of ischemic stroke.

Yang L, Shah KK, Abbruscato TJ.

Methods Mol Biol. 2012;814:451-66. doi: 10.1007/978-1-61779-452-0_30.

PMID:
22144325
18.

In vitro models of the blood-brain barrier.

Shah KK, Yang L, Abbruscato TJ.

Methods Mol Biol. 2012;814:431-49. doi: 10.1007/978-1-61779-452-0_29.

PMID:
22144324
19.

Characterization of neuroprotective effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia.

Yang L, Shah K, Wang H, Karamyan VT, Abbruscato TJ.

J Pharmacol Exp Ther. 2011 Nov;339(2):499-508. doi: 10.1124/jpet.111.184127. Epub 2011 Aug 19.

20.

Opioid receptor agonists reduce brain edema in stroke.

Yang L, Wang H, Shah K, Karamyan VT, Abbruscato TJ.

Brain Res. 2011 Apr 6;1383:307-16. doi: 10.1016/j.brainres.2011.01.083. Epub 2011 Jan 31.

PMID:
21281614
21.

Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions.

Paulson JR, Yang T, Selvaraj PK, Mdzinarishvili A, Van der Schyf CJ, Klein J, Bickel U, Abbruscato TJ.

J Pharmacol Exp Ther. 2010 Feb;332(2):371-9. doi: 10.1124/jpet.109.157776. Epub 2009 Nov 4.

22.

Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells.

Alfonso LF, Srivenugopal KS, Arumugam TV, Abbruscato TJ, Weidanz JA, Bhat GJ.

Int J Oncol. 2009 Mar;34(3):597-608.

PMID:
19212664
23.

A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation.

Vemula S, Roder KE, Yang T, Bhat GJ, Thekkumkara TJ, Abbruscato TJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):487-95. doi: 10.1124/jpet.108.146589. Epub 2008 Nov 3.

24.

Neuroprotection in mice by NGP1-01 after transient focal brain ischemia.

Hao J, Mdzinarishvili A, Abbruscato TJ, Klein J, Geldenhuys WJ, Van der Schyf CJ, Bickel U.

Brain Res. 2008 Feb 27;1196:113-20. doi: 10.1016/j.brainres.2007.11.075. Epub 2008 Jan 29.

PMID:
18234166
25.
26.

Evaluation of human nasal RPMI 2650 cells grown at an air-liquid interface as a model for nasal drug transport studies.

Bai S, Yang T, Abbruscato TJ, Ahsan F.

J Pharm Sci. 2008 Mar;97(3):1165-78.

PMID:
17628494
27.

Angiotensin II induces phosphorylation of glucose-regulated protein-75 in WB rat liver cells.

Krishna SB, Alfonso LF, Thekkumkara TJ, Abbruscato TJ, Bhat GJ.

Arch Biochem Biophys. 2007 Jan 1;457(1):16-28. Epub 2006 Nov 2.

28.

Nicotine exposure does not alter plasma to brain choline transfer.

Lockman PR, Gaasch J, McAfee G, Abbruscato TJ, Van der Schyf CJ, Allen DD.

Neurochem Res. 2006 Apr;31(4):503-8. Epub 2006 May 9.

PMID:
16758358
29.

Protein kinase C family members as a target for regulation of blood-brain barrier Na,K,2Cl-cotransporter during in vitro stroke conditions and nicotine exposure.

Yang T, Roder KE, Bhat GJ, Thekkumkara TJ, Abbruscato TJ.

Pharm Res. 2006 Feb;23(2):291-302. Epub 2006 Feb 7.

PMID:
16450214
30.

Methods for assessing drug-related anticholinergic activity.

Rudd KM, Raehl CL, Bond CA, Abbruscato TJ, Stenhouse AC.

Pharmacotherapy. 2005 Nov;25(11):1592-601. Review.

PMID:
16232021
31.

Tobacco smoke chemicals attenuate brain-to-blood potassium transport mediated by the Na,K,2Cl-cotransporter during hypoxia-reoxygenation.

Paulson JR, Roder KE, McAfee G, Allen DD, Van der Schyf CJ, Abbruscato TJ.

J Pharmacol Exp Ther. 2006 Jan;316(1):248-54. Epub 2005 Sep 20.

PMID:
16174793
32.

Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine.

Lockman PR, Van der Schyf CJ, Abbruscato TJ, Allen DD.

J Neurochem. 2005 Jul;94(1):37-44.

33.

NGP1-01, a lipophilic polycyclic cage amine, is neuroprotective in focal ischemia.

Mdzinarishvili A, Geldenhuys WJ, Abbruscato TJ, Bickel U, Klein J, Van der Schyf CJ.

Neurosci Lett. 2005 Jul 22-29;383(1-2):49-53. Epub 2005 Apr 13.

PMID:
15936510
34.

Brain uptake kinetics of nicotine and cotinine after chronic nicotine exposure.

Lockman PR, McAfee G, Geldenhuys WJ, Van der Schyf CJ, Abbruscato TJ, Allen DD.

J Pharmacol Exp Ther. 2005 Aug;314(2):636-42. Epub 2005 Apr 21.

PMID:
15845856
35.

Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.

Hawkins BT, Abbruscato TJ, Egleton RD, Brown RC, Huber JD, Campos CR, Davis TP.

Brain Res. 2004 Nov 19;1027(1-2):48-58.

PMID:
15494156
36.

Cyclodextrins in nasal delivery of low-molecular-weight heparins: in vivo and in vitro studies.

Yang T, Hussain A, Paulson J, Abbruscato TJ, Ahsan F.

Pharm Res. 2004 Jul;21(7):1127-36.

PMID:
15290851
37.

Regulation of blood-brain barrier Na,K,2Cl-cotransporter through phosphorylation during in vitro stroke conditions and nicotine exposure.

Abbruscato TJ, Lopez SP, Roder K, Paulson JR.

J Pharmacol Exp Ther. 2004 Aug;310(2):459-68. Epub 2004 Apr 1.

PMID:
15051802
38.

In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles.

Lockman PR, Koziara J, Roder KE, Paulson J, Abbruscato TJ, Mumper RJ, Allen DD.

Pharm Res. 2003 May;20(5):705-13.

PMID:
12751624
39.
40.

Novel choline transport characteristics in Caco-2 cells.

Crowe AP, Lockman PR, Abbruscato TJ, Allen DD.

Drug Dev Ind Pharm. 2002 Aug;28(7):773-81.

PMID:
12236063
41.

Bioavailability of Ziconotide in brain: influx from blood, stability, and diffusion.

Newcomb R, Abbruscato TJ, Singh T, Nadasdi L, Davis TP, Miljanich G.

Peptides. 2000 Apr;21(4):491-501.

PMID:
10822104
42.

The effect of halogenation on blood-brain barrier permeability of a novel peptide drug.

Gentry CL, Egleton RD, Gillespie T, Abbruscato TJ, Bechowski HB, Hruby VJ, Davis TP.

Peptides. 1999;20(10):1229-38.

PMID:
10573295
43.
44.

Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.

Abbruscato TJ, Davis TP.

J Pharmacol Exp Ther. 1999 May;289(2):668-75.

PMID:
10215638
45.

Transport of opioid peptides into the central nervous system.

Egleton RD, Abbruscato TJ, Thomas SA, Davis TP.

J Pharm Sci. 1998 Nov;87(11):1433-9.

PMID:
9811502
46.

Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.

Abbruscato TJ, Thomas SA, Hruby VJ, Davis TP.

J Neurochem. 1997 Sep;69(3):1236-45.

47.

Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.

Thomas SA, Abbruscato TJ, Hau VS, Gillespie TJ, Zsigo J, Hruby VJ, Davis TP.

J Pharmacol Exp Ther. 1997 May;281(2):817-25.

PMID:
9152390
48.

The entry of [D-penicillamine2,5]enkephalin into the central nervous system: saturation kinetics and specificity.

Thomas SA, Abbruscato TJ, Hruby VJ, Davis TP.

J Pharmacol Exp Ther. 1997 Mar;280(3):1235-40.

PMID:
9067309
49.
50.

Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.

Greene DL, Hau VS, Abbruscato TJ, Bartosz H, Misicka A, Lipkowski AW, Hom S, Gillespie TJ, Hruby VJ, Davis TP.

J Pharmacol Exp Ther. 1996 Jun;277(3):1366-75.

PMID:
8667199

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