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Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure.

Lombardi M, Parolisi R, Scaroni F, Bonfanti E, Gualerzi A, Gabrielli M, Kerlero de Rosbo N, Uccelli A, Giussani P, Viani P, Garlanda C, Abbracchio MP, Chaabane L, Buffo A, Fumagalli M, Verderio C.

Acta Neuropathol. 2019 Dec;138(6):987-1012. doi: 10.1007/s00401-019-02049-1. Epub 2019 Jul 30.


Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior.

Lammi C, Bollati C, Lecca D, Abbracchio MP, Arnoldi A.

Nutrients. 2019 Jul 20;11(7). pii: E1665. doi: 10.3390/nu11071665.


Basal astrocyte and microglia activation in the central nervous system of Familial Hemiplegic Migraine Type I mice.

Magni G, Boccazzi M, Bodini A, Abbracchio MP, van den Maagdenberg AM, Ceruti S.

Cephalalgia. 2019 Jul 1:333102419861710. doi: 10.1177/0333102419861710. [Epub ahead of print]


Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug.

Gelosa P, Bonfanti E, Castiglioni L, Delgado-Garcia JM, Gruart A, Fontana L, Gotti M, Tremoli E, Lecca D, Fumagalli M, Cimino M, Aigner L, Abbracchio MP, Sironi L.

Pharmacol Res. 2019 Apr;142:223-236. doi: 10.1016/j.phrs.2019.02.025. Epub 2019 Feb 25.


Purple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain: Role of Microglia.

Magni G, Marinelli A, Riccio D, Lecca D, Tonelli C, Abbracchio MP, Petroni K, Ceruti S.

Front Cell Neurosci. 2018 Nov 5;12:378. doi: 10.3389/fncel.2018.00378. eCollection 2018.


Steps towards Collective Sustainability in Biomedical Research.

Salvetti M, Lubetzki C, Kapoor R, Ristori G, Costa E, Battaglia MA, Andreaus M, Abbracchio MP, Matarese G, Zaratin P.

Trends Mol Med. 2018 May;24(5):429-432. doi: 10.1016/j.molmed.2018.03.001. Epub 2018 Mar 24.


Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination.

Coppolino GT, Marangon D, Negri C, Menichetti G, Fumagalli M, Gelosa P, Dimou L, Furlan R, Lecca D, Abbracchio MP.

Glia. 2018 May;66(5):1118-1130. doi: 10.1002/glia.23305. Epub 2018 Feb 9.


Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases.

Fumagalli M, Lecca D, Abbracchio MP, Ceruti S.

Front Pharmacol. 2017 Dec 19;8:941. doi: 10.3389/fphar.2017.00941. eCollection 2017. Review.


Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine.

Fumagalli M, Lecca D, Coppolino GT, Parravicini C, Abbracchio MP.

Adv Exp Med Biol. 2017;1051:169-192. doi: 10.1007/5584_2017_92. Review.


The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.

Bonfanti E, Gelosa P, Fumagalli M, Dimou L, Viganò F, Tremoli E, Cimino M, Sironi L, Abbracchio MP.

Cell Death Dis. 2017 Jun 8;8(6):e2871. doi: 10.1038/cddis.2017.256.


MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis.

Lecca D, Marangon D, Coppolino GT, Méndez AM, Finardi A, Costa GD, Martinelli V, Furlan R, Abbracchio MP.

Sci Rep. 2016 Oct 4;6:34503. doi: 10.1038/srep34503.


A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro.

Boccazzi M, Lecca D, Marangon D, Guagnini F, Abbracchio MP, Ceruti S.

Purinergic Signal. 2016 Dec;12(4):661-672. Epub 2016 Aug 20.


Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate.

Lecca D, Fumagalli M, Ceruti S, Abbracchio MP.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150433. doi: 10.1098/rstb.2015.0433. Review.


SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.

Meraviglia V, Ulivi AF, Boccazzi M, Valenza F, Fratangeli A, Passafaro M, Lecca D, Stagni F, Giacomini A, Bartesaghi R, Abbracchio MP, Ceruti S, Rosa P.

Glia. 2016 Aug;64(8):1437-60. doi: 10.1002/glia.23015. Epub 2016 Jun 6.


A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights.

Parravicini C, Daniele S, Palazzolo L, Trincavelli ML, Martini C, Zaratin P, Primi R, Coppolino G, Gianazza E, Abbracchio MP, Eberini I.

Cell Signal. 2016 Jun;28(6):631-42. doi: 10.1016/j.cellsig.2016.03.001. Epub 2016 Mar 10.


Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

Marschallinger J, Schäffner I, Klein B, Gelfert R, Rivera FJ, Illes S, Grassner L, Janssen M, Rotheneichner P, Schmuckermair C, Coras R, Boccazzi M, Chishty M, Lagler FB, Renic M, Bauer HC, Singewald N, Blümcke I, Bogdahn U, Couillard-Despres S, Lie DC, Abbracchio MP, Aigner L.

Nat Commun. 2015 Oct 27;6:8466. doi: 10.1038/ncomms9466.


GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury.

Viganò F, Schneider S, Cimino M, Bonfanti E, Gelosa P, Sironi L, Abbracchio MP, Dimou L.

Glia. 2016 Feb;64(2):287-99. doi: 10.1002/glia.22929. Epub 2015 Oct 14.


CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17.

Fumagalli M, Lecca D, Abbracchio MP.

Neuropharmacology. 2016 May;104:82-93. doi: 10.1016/j.neuropharm.2015.10.005. Epub 2015 Oct 8. Review.


The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization.

Fumagalli M, Bonfanti E, Daniele S, Zappelli E, Lecca D, Martini C, Trincavelli ML, Abbracchio MP.

Glia. 2015 Dec;63(12):2327-39. doi: 10.1002/glia.22896. Epub 2015 Jul 31.


P2Y2 receptor antagonists as anti-allodynic agents in acute and sub-chronic trigeminal sensitization: role of satellite glial cells.

Magni G, Merli D, Verderio C, Abbracchio MP, Ceruti S.

Glia. 2015 Jul;63(7):1256-69. doi: 10.1002/glia.22819. Epub 2015 Mar 16.


Nonprofit foundations spur translational research.

Zaratin P, Battaglia MA, Abbracchio MP.

Trends Pharmacol Sci. 2014 Nov;35(11):552-5. doi: 10.1016/ Epub 2014 Oct 29.


Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors.

Boda E, Di Maria S, Rosa P, Taylor V, Abbracchio MP, Buffo A.

Glia. 2015 Feb;63(2):271-86. doi: 10.1002/glia.22750. Epub 2014 Sep 12.


Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation.

Sensi C, Daniele S, Parravicini C, Zappelli E, Russo V, Trincavelli ML, Martini C, Abbracchio MP, Eberini I.

Cell Signal. 2014 Dec;26(12):2614-20. doi: 10.1016/j.cellsig.2014.08.003. Epub 2014 Aug 22.


Expression of dual nucleotides/cysteinyl-leukotrienes receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction.

Cosentino S, Castiglioni L, Colazzo F, Nobili E, Tremoli E, Rosa P, Abbracchio MP, Sironi L, Pesce M.

J Cell Mol Med. 2014 Sep;18(9):1785-96. doi: 10.1111/jcmm.12305. Epub 2014 Jun 7.


A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: G protein-coupled receptors.

Zappelli E, Daniele S, Abbracchio MP, Martini C, Trincavelli ML.

Int J Mol Sci. 2014 Apr 11;15(4):6252-64. doi: 10.3390/ijms15046252.


Chronic inflammatory diseases: do immunological patterns drive the choice of biotechnology drugs? A critical review.

Sozzani S, Abbracchio MP, Annese V, Danese S, De Pità O, De Sarro G, Maione S, Olivieri I, Parodi A, Sarzi-Puttini P.

Autoimmunity. 2014 Aug;47(5):287-306. doi: 10.3109/08916934.2014.897333. Epub 2014 Apr 3. Review.


Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor.

Gelosa P, Lecca D, Fumagalli M, Wypych D, Pignieri A, Cimino M, Verderio C, Enerbäck M, Nikookhesal E, Tremoli E, Abbracchio MP, Sironi L.

J Cereb Blood Flow Metab. 2014 Jun;34(6):979-88. doi: 10.1038/jcbfm.2014.45. Epub 2014 Mar 19.


Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?

Daniele S, Trincavelli ML, Fumagalli M, Zappelli E, Lecca D, Bonfanti E, Campiglia P, Abbracchio MP, Martini C.

Cell Signal. 2014 Jun;26(6):1310-25. doi: 10.1016/j.cellsig.2014.02.016. Epub 2014 Mar 5.


Ventral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion: effect of neuroprotective agents.

Colombo L, Parravicini C, Lecca D, Dossi E, Heine C, Cimino M, Wanke E, Illes P, Franke H, Abbracchio MP.

Neurochem Int. 2014 Jan;66:43-54. doi: 10.1016/j.neuint.2014.01.008. Epub 2014 Jan 23.


Purines regulate adult brain subventricular zone cell functions: contribution of reactive astrocytes.

Boccazzi M, Rolando C, Abbracchio MP, Buffo A, Ceruti S.

Glia. 2014 Mar;62(3):428-39. doi: 10.1002/glia.22614. Epub 2013 Dec 31.


Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury.

Franke H, Parravicini C, Lecca D, Zanier ER, Heine C, Bremicker K, Fumagalli M, Rosa P, Longhi L, Stocchetti N, De Simoni MG, Weber M, Abbracchio MP.

Purinergic Signal. 2013 Sep;9(3):451-62. doi: 10.1007/s11302-013-9366-3. Epub 2013 Jun 26.


UDP-glucose enhances outward K(+) currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors.

Coppi E, Maraula G, Fumagalli M, Failli P, Cellai L, Bonfanti E, Mazzoni L, Coppini R, Abbracchio MP, Pedata F, Pugliese AM.

Glia. 2013 Jul;61(7):1155-71. doi: 10.1002/glia.22506. Epub 2013 May 2.


Reply to: 'the discovery of a new class of synaptic transmitters in smooth muscle fifty years ago and amelioration of coronary artery thrombosis'.

Abbracchio MP, Boeynaems JM, Cattaneo M, Di Virgilio F, Illes P, Inoue K, Jacobson KA, Teresa Miras-Portugal M, Ralevic V, Robson SC, Verkhratsky A, Zimmermann H.

Acta Physiol (Oxf). 2013 Jun;208(2):139-40. doi: 10.1111/apha.12101. Epub 2013 Apr 17. No abstract available.


Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study.

Trincavelli ML, Da Pozzo E, Ciampi O, Cuboni S, Daniele S, Abbracchio MP, Martini C.

Int J Mol Sci. 2013 Jan 24;14(2):2258-81. doi: 10.3390/ijms14022258.


The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells.

Fratangeli A, Parmigiani E, Fumagalli M, Lecca D, Benfante R, Passafaro M, Buffo A, Abbracchio MP, Rosa P.

J Biol Chem. 2013 Feb 15;288(7):5241-56. doi: 10.1074/jbc.M112.404996. Epub 2013 Jan 3.


Adenosine signaling in glioma cells.

Ceruti S, Abbracchio MP.

Adv Exp Med Biol. 2013;986:13-30. doi: 10.1007/978-94-007-4719-7_2. Review.


Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair.

Ulrich H, Abbracchio MP, Burnstock G.

Stem Cell Rev Rep. 2012 Sep;8(3):755-67. doi: 10.1007/s12015-012-9372-9. Review.


Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death.

Lecca D, Ceruti S, Fumagalli M, Abbracchio MP.

Purinergic Signal. 2012 Sep;8(3):539-57. doi: 10.1007/s11302-012-9310-y. Epub 2012 Apr 12. Review.


The GPR17 receptor in NG2 expressing cells: focus on in vivo cell maturation and participation in acute trauma and chronic damage.

Boda E, Viganò F, Rosa P, Fumagalli M, Labat-Gest V, Tempia F, Abbracchio MP, Dimou L, Buffo A.

Glia. 2011 Dec;59(12):1958-73. doi: 10.1002/glia.21237. Epub 2011 Sep 28.


Purinergic signalling: from normal behaviour to pathological brain function.

Burnstock G, Krügel U, Abbracchio MP, Illes P.

Prog Neurobiol. 2011 Oct;95(2):229-74. doi: 10.1016/j.pneurobio.2011.08.006. Epub 2011 Sep 1. Review.


Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors.

Cosentino S, Banfi C, Burbiel JC, Luo H, Tremoli E, Abbracchio MP.

J Cell Mol Med. 2012 May;16(5):1074-84. doi: 10.1111/j.1582-4934.2011.01382.x.


In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases.

Eberini I, Daniele S, Parravicini C, Sensi C, Trincavelli ML, Martini C, Abbracchio MP.

J Comput Aided Mol Des. 2011 Aug;25(8):743-52. doi: 10.1007/s10822-011-9455-8. Epub 2011 Jul 9.


Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation.

Barosi G, Bosi A, Abbracchio MP, Danesi R, Genazzani A, Corradini P, Pane F, Tura S.

Haematologica. 2011 Jul;96(7):937-42. doi: 10.3324/haematol.2011.041210. No abstract available.


Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier.

Ceruti S, Colombo L, Magni G, Viganò F, Boccazzi M, Deli MA, Sperlágh B, Abbracchio MP, Kittel A.

Neurochem Int. 2011 Aug;59(2):259-71. doi: 10.1016/j.neuint.2011.05.013. Epub 2011 Jun 6.


Role of purinergic signalling in neuro-immune cells and adult neural progenitors.

Fumagalli M, Lecca D, Abbracchio MP.

Front Biosci (Landmark Ed). 2011 Jun 1;16:2326-41. Review.


Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands.

Daniele S, Trincavelli ML, Gabelloni P, Lecca D, Rosa P, Abbracchio MP, Martini C.

J Pharmacol Exp Ther. 2011 Aug;338(2):559-67. doi: 10.1124/jpet.110.178715. Epub 2011 Apr 29.


Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain.

Ceruti S, Villa G, Fumagalli M, Colombo L, Magni G, Zanardelli M, Fabbretti E, Verderio C, van den Maagdenberg AM, Nistri A, Abbracchio MP.

J Neurosci. 2011 Mar 9;31(10):3638-49. doi: 10.1523/JNEUROSCI.6440-10.2011.


Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

Marucci G, Lammi C, Buccioni M, Dal Ben D, Lambertucci C, Amantini C, Santoni G, Kandhavelu M, Abbracchio MP, Lecca D, Volpini R, Cristalli G.

Anal Biochem. 2011 Jul 15;414(2):300-2. doi: 10.1016/j.ab.2011.02.028. Epub 2011 Feb 24.


Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death.

Ceruti S, Viganò F, Boda E, Ferrario S, Magni G, Boccazzi M, Rosa P, Buffo A, Abbracchio MP.

Glia. 2011 Mar;59(3):363-78. doi: 10.1002/glia.21107. Epub 2010 Dec 1.


Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation.

Fumagalli M, Daniele S, Lecca D, Lee PR, Parravicini C, Fields RD, Rosa P, Antonucci F, Verderio C, Trincavelli ML, Bramanti P, Martini C, Abbracchio MP.

J Biol Chem. 2011 Mar 25;286(12):10593-604. doi: 10.1074/jbc.M110.162867. Epub 2011 Jan 5.

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