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Items: 1 to 50 of 108


Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.

Manville RW, Abbott GW.

FASEB J. 2019 Jul 16:fj201900485R. doi: 10.1096/fj.201900485R. [Epub ahead of print]


The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury.

Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW.

FASEB J. 2019 Sep;33(9):9762-9774. doi: 10.1096/fj.201802519R. Epub 2019 Jun 4.


Teamwork: Ion channels and transporters join forces in the brain.

Manville RW, Abbott GW.

Neuropharmacology. 2019 Apr 5. pii: S0028-3908(19)30118-2. doi: 10.1016/j.neuropharm.2019.04.007. [Epub ahead of print]


Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice.

Hu Z, Jepps TA, Zhou L, Liu J, Li M, Abbott GW.

Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R552-R562. doi: 10.1152/ajpregu.00251.2018. Epub 2019 Feb 13.


AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death.

Hu Z, Liu J, Zhou L, Tian X, Abbott GW.

Physiol Rep. 2019 Feb;7(3):e13957. doi: 10.14814/phy2.13957.


KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity.

Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW.

J Cell Physiol. 2019 Aug;234(8):13361-13369. doi: 10.1002/jcp.28013. Epub 2019 Jan 5.


Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation.

De Silva AM, Manville RW, Abbott GW.

Sci Adv. 2018 Nov 14;4(11):eaav0824. doi: 10.1126/sciadv.aav0824. eCollection 2018 Nov.


Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia.

David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW.

FASEB J. 2019 Feb;33(2):2537-2552. doi: 10.1096/fj.201800502R. Epub 2018 Oct 5.


Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.

Manville RW, Abbott GW.

Nat Commun. 2018 Sep 21;9(1):3845. doi: 10.1038/s41467-018-06339-2.


Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels.

Manville RW, Abbott GW.

Mol Pharmacol. 2018 Oct;94(4):1155-1163. doi: 10.1124/mol.118.112953. Epub 2018 Jul 18.


Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury.

Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW.

PLoS One. 2018 May 16;13(5):e0196186. doi: 10.1371/journal.pone.0196186. eCollection 2018.


Direct neurotransmitter activation of voltage-gated potassium channels.

Manville RW, Papanikolaou M, Abbott GW.

Nat Commun. 2018 May 10;9(1):1847. doi: 10.1038/s41467-018-04266-w.


β Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation.

Abbott GW.

Front Physiol. 2017 Sep 1;8:646. doi: 10.3389/fphys.2017.00646. eCollection 2017.


Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits.

Alachkar A, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O.

Mol Psychiatry. 2018 Feb;23(2):282-294. doi: 10.1038/mp.2017.164. Epub 2017 Aug 15.


SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.

Manville RW, Neverisky DL, Abbott GW.

Biophys J. 2017 Aug 8;113(3):613-626. doi: 10.1016/j.bpj.2017.06.055.


Chansporter complexes in cell signaling.

Abbott GW.

FEBS Lett. 2017 Sep;591(17):2556-2576. doi: 10.1002/1873-3468.12755. Epub 2017 Aug 2. Review.


Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats.

Hu Z, Chen M, Zhang P, Liu J, Abbott GW.

Cardiovasc Diabetol. 2017 Apr 26;16(1):57. doi: 10.1186/s12933-017-0537-3.


Targeted deletion of Kcne3 impairs skeletal muscle function in mice.

King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW.

FASEB J. 2017 Jul;31(7):2937-2947. doi: 10.1096/fj.201600965RR. Epub 2017 Mar 29.


KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk.

Neverisky DL, Abbott GW.

FASEB J. 2017 Jul;31(7):2828-2838. doi: 10.1096/fj.201601334R. Epub 2017 Mar 10.


Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus.

Lee SM, Baik J, Nguyen D, Nguyen V, Liu S, Hu Z, Abbott GW.

FASEB J. 2017 Jun;31(6):2674-2685. doi: 10.1096/fj.201601347. Epub 2017 Mar 9.


β Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants.

Abbott GW.

Front Physiol. 2017 Feb 8;8:66. doi: 10.3389/fphys.2017.00066. eCollection 2017.


Involvement of glycogen synthase kinase-3β in liver ischemic conditioning induced cardioprotection against myocardial ischemia and reperfusion injury in rats.

Yang S, Abbott GW, Gao WD, Liu J, Luo C, Hu Z.

J Appl Physiol (1985). 2017 May 1;122(5):1095-1105. doi: 10.1152/japplphysiol.00862.2016. Epub 2017 Feb 2.


Correction: Channel-transporter complexes: an emerging theme in cell signalling.

Abbott GW.

Biochem J. 2016 Dec 15;473(24):4714. No abstract available.


Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4.

Abbott GW.

Sci Rep. 2016 Dec 6;6:38412. doi: 10.1038/srep38412.


Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3β-Dependent Mechanism.

Hu Z, Hu S, Yang S, Chen M, Zhang P, Liu J, Abbott GW.

PLoS One. 2016 Oct 21;11(10):e0165123. doi: 10.1371/journal.pone.0165123. eCollection 2016.


Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity.

Abbott GW, Jepps TA.

J Vasc Res. 2016;53(3-4):138-148. Epub 2016 Oct 7.


KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis.

Abbott GW.

Gene. 2016 Nov 30;593(2):249-60. doi: 10.1016/j.gene.2016.07.069. Epub 2016 Jul 30. Review.


Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.

Abbott GW.

FASEB J. 2016 Aug;30(8):2959-69. doi: 10.1096/fj.201600467R. Epub 2016 May 9.


Ion channel-transporter interactions.

Neverisky DL, Abbott GW.

Crit Rev Biochem Mol Biol. 2015 Jul-Aug;51(4):257-67. doi: 10.3109/10409238.2016.1172553. Epub 2016 Apr 20. Review.


Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia.

Lee SM, Nguyen D, Anand M, Kant R, Köhncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW.

Sci Rep. 2016 Mar 17;6:23118. doi: 10.1038/srep23118.


KCNE2 and gastric cancer: bench to bedside.

Abbott GW, Roepke TK.

Oncotarget. 2016 Apr 5;7(14):17286-7. doi: 10.18632/oncotarget.7921. No abstract available.


Kcne2 deletion attenuates acute post-ischaemia/reperfusion myocardial infarction.

Hu Z, Crump SM, Zhang P, Abbott GW.

Cardiovasc Res. 2016 May 15;110(2):227-37. doi: 10.1093/cvr/cvw048. Epub 2016 Mar 6.


KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.

Abbott GW.

Gene. 2016 Jan 15;576(1 Pt 1):1-13. doi: 10.1016/j.gene.2015.09.059. Epub 2015 Sep 26. Review.


Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice.

Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW.

FASEB J. 2016 Jan;30(1):360-9. doi: 10.1096/fj.15-278754. Epub 2015 Sep 23.


Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death.

Lee SM, Nguyen D, Hu Z, Abbott GW.

J Mol Cell Cardiol. 2015 Oct;87:148-51. doi: 10.1016/j.yjmcc.2015.08.013. Epub 2015 Aug 22.


The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.

Abbott GW.

Gene. 2015 Sep 15;569(2):162-72. doi: 10.1016/j.gene.2015.06.061. Epub 2015 Jun 27. Review.


Ion channels under the sun.

Abbott GW, Pitt GS.

FASEB J. 2014 May;28(5):1957-62. doi: 10.1096/fj.14-0501ufm. No abstract available.


KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT.

Sci Signal. 2014 Mar 4;7(315):ra22. doi: 10.1126/scisignal.2005025.


Arrhythmogenic KCNE gene variants: current knowledge and future challenges.

Crump SM, Abbott GW.

Front Genet. 2014 Jan 24;5:3. doi: 10.3389/fgene.2014.00003. eCollection 2014. Review.


Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death.

Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW.

Circ Cardiovasc Genet. 2014 Feb;7(1):33-42. doi: 10.1161/CIRCGENETICS.113.000315. Epub 2014 Jan 8.


Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons.

Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ.

J Biol Chem. 2014 Feb 28;289(9):5889-903. doi: 10.1074/jbc.M113.522060. Epub 2014 Jan 8.


NHE isoform switching and KChIP2 upregulation in aging porcine atria.

Kant R, Hu Z, Malhotra JK, Krogh-Madsen T, Christini DJ, Heerdt PM, Abbott GW.

PLoS One. 2013 Dec 23;8(12):e82951. doi: 10.1371/journal.pone.0082951. eCollection 2013.


Kcne3 deletion initiates extracardiac arrhythmogenesis in mice.

Hu Z, Crump SM, Anand M, Kant R, Levi R, Abbott GW.

FASEB J. 2014 Feb;28(2):935-45. doi: 10.1096/fj.13-241828. Epub 2013 Nov 13.


Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats.

Hu ZY, Abbott GW, Fang YD, Huang YS, Liu J.

J Physiol Sci. 2013 Jul;63(4):251-61. doi: 10.1007/s12576-013-0261-z. Epub 2013 Apr 27.


KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing?

Abbott GW.

Expert Rev Clin Pharmacol. 2013 Jan;6(1):49-60. doi: 10.1586/ecp.12.76. Review.


Interaction between soluble and membrane-embedded potassium channel peptides monitored by Fourier transform infrared spectroscopy.

Abbott GW, Ramesh B, Srai SK.

PLoS One. 2012;7(11):e49070. doi: 10.1371/journal.pone.0049070. Epub 2012 Nov 8.


Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.

Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA.

PLoS One. 2012;7(8):e42756. doi: 10.1371/journal.pone.0042756. Epub 2012 Aug 3.

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