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Items: 1 to 50 of 91

1.

Evaluation of in situ generated valproyl 1-O-β-acyl glucuronide in valproic acid toxicity in sandwich-cultured rat hepatocytes.

Surendradoss J, Chang TK, Abbott FS.

Drug Metab Dispos. 2014 Nov;42(11):1834-42. doi: 10.1124/dmd.114.059352. Epub 2014 Aug 21.

PMID:
25147275
2.

A rapid and sensitive assay to quantify valproyl 1-O-acyl glucuronide in supernatants of sandwich-cultured rat hepatocytes using ultra-high performance liquid chromatography-tandem mass spectrometry.

Surendradoss J, Szeitz A, Teng XW, Chang TK, Abbott FS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:40-9. doi: 10.1016/j.jchromb.2013.06.006. Epub 2013 Jun 13.

PMID:
23827518
3.

Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.

Surendradoss J, Chang TK, Abbott FS.

Toxicol Appl Pharmacol. 2012 Nov 1;264(3):413-22. doi: 10.1016/j.taap.2012.08.018. Epub 2012 Aug 25.

PMID:
22940460
4.

Effects of valproic acid on organic acid metabolism in children: a metabolic profiling study.

Price KE, Pearce RE, Garg UC, Heese BA, Smith LD, Sullivan JE, Kennedy MJ, Bale JF Jr, Ward RM, Chang TK, Abbott FS, Leeder JS.

Clin Pharmacol Ther. 2011 Jun;89(6):867-74. doi: 10.1038/clpt.2011.47. Epub 2011 May 4.

5.

Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.

Kiang TK, Teng XW, Surendradoss J, Karagiozov S, Abbott FS, Chang TK.

Toxicol Appl Pharmacol. 2011 May 1;252(3):318-24. doi: 10.1016/j.taap.2011.03.004. Epub 2011 Mar 22.

PMID:
21397622
6.

Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.

Kiang TK, Teng XW, Karagiozov S, Surendradoss J, Chang TK, Abbott FS.

Toxicol Sci. 2010 Dec;118(2):501-9. doi: 10.1093/toxsci/kfq294. Epub 2010 Sep 22.

PMID:
20861068
7.
8.

Kinetics of valproic acid glucuronidation: evidence for in vivo autoactivation.

Wong H, Tong V, Riggs KW, Rurak DW, Abbott FS, Kumar S.

Drug Metab Dispos. 2007 Aug;35(8):1380-6. Epub 2007 May 11.

PMID:
17496206
9.

Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity.

Chang TK, Abbott FS.

Drug Metab Rev. 2006;38(4):627-39. Review.

PMID:
17145692
10.

Oxidative stress in children receiving valproic acid.

Michoulas A, Tong V, Teng XW, Chang TK, Abbott FS, Farrell K.

J Pediatr. 2006 Nov;149(5):692-6.

PMID:
17095346
11.

Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.

Kiang TK, Ho PC, Anari MR, Tong V, Abbott FS, Chang TK.

Toxicol Sci. 2006 Dec;94(2):261-71. Epub 2006 Aug 31.

PMID:
16945988
12.

Valproic acid glucuronidation is associated with increases in 15-F2t-isoprostane in rats.

Tong V, Teng XW, Karagiozov S, Chang TK, Abbott FS.

Free Radic Biol Med. 2005 Jun 1;38(11):1471-83.

PMID:
15890621
13.

Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.

Tong V, Teng XW, Chang TK, Abbott FS.

Toxicol Sci. 2005 Aug;86(2):427-35. Epub 2005 Apr 27.

PMID:
15858223
14.

Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes.

Tong V, Teng XW, Chang TK, Abbott FS.

Toxicol Sci. 2005 Aug;86(2):436-43. Epub 2005 Apr 27.

PMID:
15858222
15.

Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes.

Ho PC, Abbott FS, Zanger UM, Chang TK.

Pharmacogenomics J. 2003;3(6):335-42.

PMID:
14597963
16.

The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.

Tong V, Chang TK, Chen J, Abbott FS.

Free Radic Biol Med. 2003 Jun 1;34(11):1435-46.

PMID:
12757854
17.

Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients.

Gopaul VS, Tang W, Farrell K, Abbott FS.

Drug Metab Dispos. 2003 Jan;31(1):114-21.

PMID:
12485960
18.
19.

Dose-dependent pharmacokinetics and metabolism of valproic acid in newborn lambs and adult sheep.

Wong H, Rurak DW, Kumar S, Kwan E, Abbott FS, Riggs KW.

Drug Metab Dispos. 2001 May;29(5):664-75.

PMID:
11302932
20.

In vitro investigation of the hepatic extraction of RSD1070, a novel antiarrhythmic compound.

Tong V, Abbott FS, Mbofana S, Walker MJ.

J Pharm Pharm Sci. 2001 Jan-Apr;4(1):15-23.

21.

Ontogeny of valproic acid disposition and metabolism: a developmental study in postnatal lambs and adult sheep.

Wong H, Kumar S, Rurak DW, Kwan E, Abbott FS, Riggs KW.

Drug Metab Dispos. 2000 Aug;28(8):912-9.

PMID:
10901700
22.
24.

Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.

Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.

Drug Metab Dispos. 2000 Jul;28(7):857-64.

PMID:
10859160
25.

Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance.

Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.

Drug Metab Dispos. 2000 Jul;28(7):845-56.

PMID:
10859159
26.

Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals.

Gopaul SV, Farrell K, Abbott FS.

Drug Metab Dispos. 2000 Jul;28(7):823-32.

PMID:
10859157
27.

LC/MS analysis of hydroxylation products of salicylate as an indicator of in vivo oxidative stress.

Tabatabaei AR, Abbott FS.

Free Radic Biol Med. 1999 Apr;26(7-8):1054-8.

PMID:
10232850
28.

Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.

Tabatabaei AR, Thies RL, Abbott FS.

Chem Res Toxicol. 1999 Apr;12(4):323-30. Erratum in: Chem Res Toxicol. 2002 Jul;15(7):999..

PMID:
10207120
30.

A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes.

Tabatabaei AR, Thies RL, Farrell K, Abbott FS.

Fundam Appl Toxicol. 1997 Jun;37(2):181-9.

PMID:
9242591
33.

Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.

Jurima-Romet M, Abbott FS, Tang W, Huang HS, Whitehouse LW.

Toxicology. 1996 Aug 1;112(1):69-85.

PMID:
8792850
34.

Comparative effects of carbamazepine and carbamazepine-10,11-epoxide on hepatic cytochromes P450 in the rat.

Panesar SK, Bandiera SM, Abbott FS.

Drug Metab Dispos. 1996 Jun;24(6):619-27.

PMID:
8781776
35.

Binding of a valproate metabolite to the trifunctional protein of fatty acid oxidation.

Baldwin GS, Abbott FS, Nau H.

FEBS Lett. 1996 Apr 8;384(1):58-60.

38.

The pharmacokinetics of valproic acid in pregnant sheep after maternal and fetal intravenous bolus administration.

Gordon JD, Riggs KW, Rurak DW, Kwan E, Hall C, Abbott FS.

Drug Metab Dispos. 1995 Dec;23(12):1383-9.

PMID:
8689948
40.

Structure-activity relationships of unsaturated analogues of valproic acid.

Palaty J, Abbott FS.

J Med Chem. 1995 Aug 18;38(17):3398-406.

PMID:
7650693
41.
42.

Determination of valproic acid and its metabolites using gas chromatography with mass-selective detection: application to serum and urine samples from sheep.

Yu D, Gordon JD, Zheng J, Panesar SK, Riggs KW, Rurak DW, Abbott FS.

J Chromatogr B Biomed Appl. 1995 Apr 21;666(2):269-81.

PMID:
7633603
43.
44.

New approaches for drug and kinetic analysis in the maternal-fetal unit.

Tonn GR, Doroudian A, Gordon JG, Rurak DW, Riggs KW, Abbott FS, Axelson JE.

NIDA Res Monogr. 1995;154:175-202. Review.

PMID:
8606744
45.

Rapid assay for gamma-aminobutyric acid in mouse brain synaptosomes using gas chromatography-mass spectrometry.

Palaty J, Burton R, Abbott FS.

J Chromatogr B Biomed Appl. 1994 Dec 2;662(1):85-90.

PMID:
7894697
46.

Determination of metoclopramide and two of its metabolites using a sensitive and selective gas chromatographic-mass spectrometric assay.

Riggs KW, Szeitz A, Rurak DW, Mutlib AE, Abbott FS, Axelson JE.

J Chromatogr B Biomed Appl. 1994 Oct 14;660(2):315-25.

PMID:
7866522
48.

Transplacental and nonplacental clearances, metabolism and pharmacodynamics of labetalol in the fetal lamb after direct intravenous administration.

Yeleswaram K, Rurak DW, Kwan E, Hall C, Doroudian A, Wright MR, Abbott FS, Axelson JE.

J Pharmacol Exp Ther. 1993 Oct;267(1):425-31.

PMID:
8229771
49.

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