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Items: 1 to 50 of 100

1.

Connecting cancer relapse with senescence.

Pluquet O, Abbadie C, Coqueret O.

Cancer Lett. 2019 Oct 28;463:50-58. doi: 10.1016/j.canlet.2019.08.004. Epub 2019 Aug 9.

PMID:
31404612
2.

Pre-malignant transformation by senescence evasion is prevented by the PERK and ATF6alpha branches of the Unfolded Protein Response.

Drullion C, Marot G, Martin N, Desle J, Saas L, Salazar-Cardozo C, Bouali F, Pourtier A, Abbadie C, Pluquet O.

Cancer Lett. 2018 Dec 1;438:187-196. doi: 10.1016/j.canlet.2018.09.008. Epub 2018 Sep 11.

PMID:
30213560
3.

[Senescence and cancer: double-dealing].

Goy E, Abbadie C.

Med Sci (Paris). 2018 Mar;34(3):223-230. doi: 10.1051/medsci/20183403010. Epub 2018 Mar 16. Review. French.

4.

Fast spatial-selective delivery into live cells.

Xiong R, Drullion C, Verstraelen P, Demeester J, Skirtach AG, Abbadie C, De Vos WH, De Smedt SC, Braeckmans K.

J Control Release. 2017 Nov 28;266:198-204. doi: 10.1016/j.jconrel.2017.09.033. Epub 2017 Sep 28.

PMID:
28965859
5.

The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.

Cormenier J, Martin N, Deslé J, Salazar-Cardozo C, Pourtier A, Abbadie C, Pluquet O.

Mech Ageing Dev. 2018 Mar;170:82-91. doi: 10.1016/j.mad.2017.08.003. Epub 2017 Aug 10.

PMID:
28803844
6.

Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?

Abbadie C, Pluquet O, Pourtier A.

Cell Mol Life Sci. 2017 Dec;74(24):4471-4509. doi: 10.1007/s00018-017-2587-9. Epub 2017 Jul 13. Review.

PMID:
28707011
7.

Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder.

Di Salvo J, Nagabukuro H, Wickham LA, Abbadie C, DeMartino JA, Fitzmaurice A, Gichuru L, Kulick A, Donnelly MJ, Jochnowitz N, Hurley AL, Pereira A, Sanfiz A, Veronin G, Villa K, Woods J, Zamlynny B, Zycband E, Salituro GM, Frenkl T, Weber AE, Edmondson SD, Struthers M.

J Pharmacol Exp Ther. 2017 Feb;360(2):346-355. doi: 10.1124/jpet.116.237313. Epub 2016 Dec 13.

PMID:
27965369
8.

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

Paget S, Dubuissez M, Dehennaut V, Nassour J, Harmon BT, Spruyt N, Loison I, Abbadie C, Rood BR, Leprince D.

Oncotarget. 2017 Jan 10;8(2):2916-2935. doi: 10.18632/oncotarget.13807.

9.

A novel role for DNA single-strand breaks in senescence and neoplastic escape of epithelial cells.

Nassour J, Abbadie C.

Mol Cell Oncol. 2016 May 31;3(5):e1190885. eCollection 2016.

10.

ATF6α regulates morphological changes associated with senescence in human fibroblasts.

Druelle C, Drullion C, Deslé J, Martin N, Saas L, Cormenier J, Malaquin N, Huot L, Slomianny C, Bouali F, Vercamer C, Hot D, Pourtier A, Chevet E, Abbadie C, Pluquet O.

Oncotarget. 2016 Oct 18;7(42):67699-67715. doi: 10.18632/oncotarget.11505.

11.

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.

Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, Bouali F, Sabatier L, Wernert N, Pinte S, Gilson E, Pourtier A, Pluquet O, Abbadie C.

Nat Commun. 2016 Jan 29;7:10399. doi: 10.1038/ncomms10399.

12.

A biophysical model of cell evolution after cytotoxic treatments: Damage, repair and cell response.

Tomezak M, Abbadie C, Lartigau E, Cleri F.

J Theor Biol. 2016 Jan 21;389:146-58. doi: 10.1016/j.jtbi.2015.10.017. Epub 2015 Nov 6.

PMID:
26549470
13.

The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.

Pluquet O, Pourtier A, Abbadie C.

Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C415-25. doi: 10.1152/ajpcell.00334.2014. Epub 2014 Dec 24. Review.

14.

Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion.

Deruy E, Nassour J, Martin N, Vercamer C, Malaquin N, Bertout J, Chelli F, Pourtier A, Pluquet O, Abbadie C.

Cell Death Dis. 2014 Dec 18;5:e1577. doi: 10.1038/cddis.2014.533.

15.

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.

Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, Chang L, Bakshi RK, Dellureficio JP, Hong Q, McLaughlin M, Belyk KM, Krska SW, Makarewicz AK, Martel EJ, Leone JF, Frey L, Karanam B, Madeira M, Alvaro R, Shuman J, Salituro G, Terebetski JL, Jochnowitz N, Mistry S, McGowan E, Hajdu R, Rosenbach M, Abbadie C, Alexander JP, Shiao LL, Sullivan KM, Nargund RP, Wyvratt MJ, Lin LS, DeVita RJ.

ACS Med Chem Lett. 2014 Apr 10;5(6):717-21. doi: 10.1021/ml5001239. eCollection 2014 Jun 12.

16.

Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes.

Martin N, Salazar-Cardozo C, Vercamer C, Ott L, Marot G, Slijepcevic P, Abbadie C, Pluquet O.

Mol Cancer. 2014 Jun 14;13:151. doi: 10.1186/1476-4598-13-151.

17.

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.

Liu P, Hamill TG, Chioda M, Chobanian H, Fung S, Guo Y, Chang L, Bakshi R, Hong Q, Dellureficio J, Lin LS, Abbadie C, Alexander J, Jin H, Mandala S, Shiao LL, Li W, Sanabria S, Williams D, Zeng Z, Hajdu R, Jochnowitz N, Rosenbach M, Karanam B, Madeira M, Salituro G, Powell J, Xu L, Terebetski JL, Leone JF, Miller P, Cook J, Holahan M, Joshi A, O'Malley S, Purcell M, Posavec D, Chen TB, Riffel K, Williams M, Hargreaves R, Sullivan KA, Nargund RP, DeVita RJ.

ACS Med Chem Lett. 2013 Apr 20;4(6):509-13. doi: 10.1021/ml4000996. eCollection 2013 Jun 13.

18.

Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide.

Shao PP, Ye F, Chakravarty PK, Herrington JB, Dai G, Bugianesi RM, Haedo RJ, Swensen AM, Warren VA, Smith MM, Garcia ML, McManus OB, Lyons KA, Li X, Green M, Jochnowitz N, McGowan E, Mistry S, Sun SY, Abbadie C, Kaczorowski GJ, Duffy JL.

ACS Med Chem Lett. 2013 Sep 8;4(11):1064-8. doi: 10.1021/ml4002612. eCollection 2013 Nov 14.

19.

Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts.

Martien S, Pluquet O, Vercamer C, Malaquin N, Martin N, Gosselin K, Pourtier A, Abbadie C.

Biochim Biophys Acta. 2013 Jul;1831(7):1217-27.

PMID:
24046862
20.

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.

Malaquin N, Vercamer C, Bouali F, Martien S, Deruy E, Wernert N, Chwastyniak M, Pinet F, Abbadie C, Pourtier A.

PLoS One. 2013 May 10;8(5):e63607. doi: 10.1371/journal.pone.0063607. Print 2013.

21.

A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.

Hoyt SB, London C, Abbadie C, Felix JP, Garcia ML, Jochnowitz N, Karanam BV, Li X, Lyons KA, McGowan E, Priest BT, Smith MM, Warren VA, Thomas-Fowlkes BS, Kaczorowski GJ, Duffy JL.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3640-5. doi: 10.1016/j.bmcl.2013.03.121. Epub 2013 Apr 5.

PMID:
23652221
22.

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.

Dehennaut V, Loison I, Dubuissez M, Nassour J, Abbadie C, Leprince D.

J Biol Chem. 2013 Apr 12;288(15):10254-64. doi: 10.1074/jbc.M112.421610. Epub 2013 Feb 15.

23.

Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.

Shao PP, Ye F, Chakravarty PK, Varughese DJ, Herrington JB, Dai G, Bugianesi RM, Haedo RJ, Swensen AM, Warren VA, Smith MM, Garcia ML, McManus OB, Lyons KA, Li X, Green M, Jochnowitz N, McGowan E, Mistry S, Sun SY, Abbadie C, Kaczorowski GJ, Duffy JL.

J Med Chem. 2012 Nov 26;55(22):9847-55. doi: 10.1021/jm301056k. Epub 2012 Nov 12.

PMID:
23098566
24.

A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.

Tyagarajan S, Chakravarty PK, Park M, Zhou B, Herrington JB, Ratliff K, Bugianesi RM, Williams B, Haedo RJ, Swensen AM, Warren VA, Smith M, Garcia M, Kaczorowski GJ, McManus OB, Lyons KA, Li X, Madeira M, Karanam B, Green M, Forrest MJ, Abbadie C, McGowan E, Mistry S, Jochnowitz N, Duffy JL.

Bioorg Med Chem Lett. 2011 Jan 15;21(2):869-73. doi: 10.1016/j.bmcl.2010.11.067. Epub 2010 Nov 21.

PMID:
21195616
25.

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.

Tyagarajan S, Chakravarty PK, Zhou B, Taylor B, Eid R, Fisher MH, Parsons WH, Wyvratt MJ, Lyons KA, Klatt T, Li X, Kumar S, Williams B, Felix J, Priest BT, Brochu RM, Warren V, Smith M, Garcia M, Kaczorowski GJ, Martin WJ, Abbadie C, McGowan E, Jochnowitz N, Weber A, Duffy JL.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7479-82. doi: 10.1016/j.bmcl.2010.10.017. Epub 2010 Oct 14.

PMID:
21106456
26.

MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes.

Deruy E, Gosselin K, Vercamer C, Martien S, Bouali F, Slomianny C, Bertout J, Bernard D, Pourtier A, Abbadie C.

PLoS One. 2010 Sep 14;5(9):e12712. doi: 10.1371/journal.pone.0012712.

27.

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.

Tyagarajan S, Chakravarty PK, Zhou B, Fisher MH, Wyvratt MJ, Lyons K, Klatt T, Li X, Kumar S, Williams B, Felix J, Priest BT, Brochu RM, Warren V, Smith M, Garcia M, Kaczorowski GJ, Martin WJ, Abbadie C, McGowan E, Jochnowitz N, Parsons WH.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. doi: 10.1016/j.bmcl.2010.07.064. Epub 2010 Jul 21.

PMID:
20709552
28.

Substituted biaryl pyrazoles as sodium channel blockers.

Tyagarajan S, Chakravarty PK, Zhou B, Taylor B, Fisher MH, Wyvratt MJ, Lyons K, Klatt T, Li X, Kumar S, Williams B, Felix J, Priest BT, Brochu RM, Warren V, Smith M, Garcia M, Kaczorowski GJ, Martin WJ, Abbadie C, McGowan E, Jochnowitz N, Parsons WH.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5480-3. doi: 10.1016/j.bmcl.2010.07.080. Epub 2010 Jul 24.

PMID:
20709545
29.

Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.

Abbadie C, McManus OB, Sun SY, Bugianesi RM, Dai G, Haedo RJ, Herrington JB, Kaczorowski GJ, Smith MM, Swensen AM, Warren VA, Williams B, Arneric SP, Eduljee C, Snutch TP, Tringham EW, Jochnowitz N, Liang A, Euan MacIntyre D, McGowan E, Mistry S, White VV, Hoyt SB, London C, Lyons KA, Bunting PB, Volksdorf S, Duffy JL.

J Pharmacol Exp Ther. 2010 Aug;334(2):545-55. doi: 10.1124/jpet.110.166363. Epub 2010 May 3.

PMID:
20439438
30.

Correlation between pharmacologically-induced changes in cystometric parameters and spinal c-Fos expression in rats.

Nagabukuro H, Degenhardt A, Villa KL, Mistry SL, Gichuru L, Jochnowitz N, Abbadie C.

Auton Neurosci. 2010 Aug 25;156(1-2):19-26. doi: 10.1016/j.autneu.2010.02.006. Epub 2010 Mar 24.

PMID:
20335078
31.

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D.

EMBO J. 2010 Jan 20;29(2):376-86. doi: 10.1038/emboj.2009.342. Epub 2009 Nov 19.

32.

Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells.

Gosselin K, Martien S, Pourtier A, Vercamer C, Ostoich P, Morat L, Sabatier L, Duprez L, T'kint de Roodenbeke C, Gilson E, Malaquin N, Wernert N, Slijepcevic P, Ashtari M, Chelli F, Deruy E, Vandenbunder B, De Launoit Y, Abbadie C.

Cancer Res. 2009 Oct 15;69(20):7917-25. doi: 10.1158/0008-5472.CAN-08-2510. Epub 2009 Oct 13.

33.

A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain.

McGowan E, Hoyt SB, Li X, Lyons KA, Abbadie C.

Anesth Analg. 2009 Sep;109(3):951-8. doi: 10.1213/ane.0b013e3181b01b02.

PMID:
19690272
34.

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

Shao PP, Ye F, Weber AE, Li X, Lyons KA, Parsons WH, Garcia ML, Priest BT, Smith MM, Felix JP, Williams BS, Kaczorowski GJ, McGowan E, Abbadie C, Martin WJ, McMasters DR, Gao YD.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5334-8. doi: 10.1016/j.bmcl.2009.07.135. Epub 2009 Aug 6.

PMID:
19683443
35.

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.

Shao PP, Ye F, Weber AE, Li X, Lyons KA, Parsons WH, Garcia ML, Priest BT, Smith MM, Felix JP, Williams BS, Kaczorowski GJ, McGowan E, Abbadie C, Martin WJ, McMasters DR, Gao YD.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5329-33. doi: 10.1016/j.bmcl.2009.07.125. Epub 2009 Aug 6.

PMID:
19674896
36.

fMRI investigation of the effect of local and systemic lidocaine on noxious electrical stimulation-induced activation in spinal cord.

Zhao F, Williams M, Welsh DC, Meng X, Ritter A, Abbadie C, Cook JJ, Reicin AS, Hargreaves R, Williams DS.

Pain. 2009 Sep;145(1-2):110-9. doi: 10.1016/j.pain.2009.05.026. Epub 2009 Jun 26.

PMID:
19560271
37.

A genetic screen identifies topoisomerase 1 as a regulator of senescence.

Humbert N, Martien S, Augert A, Da Costa M, Mauen S, Abbadie C, de Launoit Y, Gil J, Bernard D.

Cancer Res. 2009 May 15;69(10):4101-6. doi: 10.1158/0008-5472.CAN-08-2864. Epub 2009 May 12.

38.

Changes in mouse mu opioid receptor Exon 7/8-like immunoreactivity following food restriction and food deprivation in rats.

Hadjimarkou MM, Abbadie C, Kasselman LJ, Pan YX, Pasternak GW, Bodnar RJ.

Synapse. 2009 Jul;63(7):585-97. doi: 10.1002/syn.20639.

39.

Senescent keratinocytes die by autophagic programmed cell death.

Gosselin K, Deruy E, Martien S, Vercamer C, Bouali F, Dujardin T, Slomianny C, Houel-Renault L, Chelli F, De Launoit Y, Abbadie C.

Am J Pathol. 2009 Feb;174(2):423-35. doi: 10.2353/ajpath.2009.080332. Epub 2009 Jan 15.

40.

Chemokines and pain mechanisms.

Abbadie C, Bhangoo S, De Koninck Y, Malcangio M, Melik-Parsadaniantz S, White FA.

Brain Res Rev. 2009 Apr;60(1):125-34. doi: 10.1016/j.brainresrev.2008.12.002. Epub 2008 Dec 25. Review.

41.

Maternal perinatal undernutrition impairs chromaffin cells proliferation in the postnatal rat.

Molendi-Coste O, Mairesse J, Aubert N, Ghzili H, Abbadie C, Vaudry H, Gonzalez B, Anouar Y, Vieau D, Breton C, Laborie C.

Horm Metab Res. 2008 Jun;40(6):386-90. doi: 10.1055/s-2008-1058091. Epub 2008 Mar 14.

PMID:
18401834
42.

Imidazopyridines: a novel class of hNav1.7 channel blockers.

London C, Hoyt SB, Parsons WH, Williams BS, Warren VA, Tschirret-Guth R, Smith MM, Priest BT, McGowan E, Martin WJ, Lyons KA, Li X, Karanam BV, Jochnowitz N, Garcia ML, Felix JP, Dean B, Abbadie C, Kaczorowski GJ, Duffy JL.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1696-701. doi: 10.1016/j.bmcl.2008.01.047. Epub 2008 Jan 18.

PMID:
18243692
43.

Acquisition of oxidative DNA damage during senescence: the first step toward carcinogenesis?

Martien S, Abbadie C.

Ann N Y Acad Sci. 2007 Nov;1119:51-63. Review.

PMID:
18056954
44.

Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.

Hoyt SB, London C, Ok H, Gonzalez E, Duffy JL, Abbadie C, Dean B, Felix JP, Garcia ML, Jochnowitz N, Karanam BV, Li X, Lyons KA, McGowan E, Macintyre DE, Martin WJ, Priest BT, Smith MM, Tschirret-Guth R, Warren VA, Williams BS, Kaczorowski GJ, Parsons WH.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6172-7. Epub 2007 Sep 11.

PMID:
17889534
45.

Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.

Menetski J, Mistry S, Lu M, Mudgett JS, Ransohoff RM, Demartino JA, Macintyre DE, Abbadie C.

Neuroscience. 2007 Nov 9;149(3):706-14. Epub 2007 Aug 14.

PMID:
17870246
46.

Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.

Hoyt SB, London C, Gorin D, Wyvratt MJ, Fisher MH, Abbadie C, Felix JP, Garcia ML, Li X, Lyons KA, McGowan E, MacIntyre DE, Martin WJ, Priest BT, Ritter A, Smith MM, Warren VA, Williams BS, Kaczorowski GJ, Parsons WH.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4630-4. Epub 2007 May 27.

PMID:
17588748
47.

Normal or stress-induced fibroblast senescence involves COX-2 activity.

Zdanov S, Bernard D, Debacq-Chainiaux F, Martien S, Gosselin K, Vercamer C, Chelli F, Toussaint O, Abbadie C.

Exp Cell Res. 2007 Aug 15;313(14):3046-56. Epub 2007 May 22.

PMID:
17560572
48.

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.

Ok D, Li C, Abbadie C, Felix JP, Fisher MH, Garcia ML, Kaczorowski GJ, Lyons KA, Martin WJ, Priest BT, Smith MM, Williams BS, Wyvratt MJ, Parsons WH.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1358-61. Epub 2005 Dec 5.

PMID:
16337121
49.

Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.

Garry EM, Delaney A, Anderson HA, Sirinathsinghji EC, Clapp RH, Martin WJ, Kinchington PR, Krah DL, Abbadie C, Fleetwood-Walker SM.

Pain. 2005 Nov;118(1-2):97-111. Epub 2005 Oct 5.

PMID:
16213091
50.

Chemokines, chemokine receptors and pain.

Abbadie C.

Trends Immunol. 2005 Oct;26(10):529-34. Review.

PMID:
16099720

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