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Items: 25


Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals.

Wesolowska-Andersen A, Zhuo Yu G, Nylander V, Abaitua F, Thurner M, Torres JM, Mahajan A, Gloyn AL, McCarthy MI.

Elife. 2020 Jan 27;9. pii: e51503. doi: 10.7554/eLife.51503.


A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function.

Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL.

Wellcome Open Res. 2019 Oct 8;4:150. doi: 10.12688/wellcomeopenres.15447.1. eCollection 2019.


Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.

Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, Artner I, Suoranta A, Gomez D, Baras A, Champon B, Payne AJ, Moralli D, Thomsen SK, Kramer P, Spiliotis I, Ramracheya R, Chabosseau P, Theodoulou A, Cheung R, van de Bunt M, Flannick J, Trombetta M, Bonora E, Wolheim CB, Sarelin L, Bonadonna RC, Rorsman P, Davies B, Brosnan J, McCarthy MI, Otonkoski T, Lagerstedt JO, Rutter GA, Gromada J, Gloyn AL, Tuomi T, Groop L.

Nat Genet. 2019 Nov;51(11):1596-1606. doi: 10.1038/s41588-019-0513-9. Epub 2019 Nov 1.


Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM.

Przystal JM, Hajji N, Khozoie C, Renziehausen A, Zeng Q, Abaitua F, Hajitou A, Suwan K, Want E, Bomalaski J, Szlosarek P, O'Neill K, Crook T, Syed N.

Cell Death Dis. 2018 Dec 13;9(12):1192. doi: 10.1038/s41419-018-1195-4.


Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.

Serwa RA, Abaitua F, Krause E, Tate EW, O'Hare P.

Chem Biol. 2015 Aug 20;22(8):1008-17. doi: 10.1016/j.chembiol.2015.06.024. Epub 2015 Aug 6.


Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets.

Barbosa S, Carreira S, Bailey D, Abaitua F, O'Hare P.

Mol Biol Cell. 2015 Aug 15;26(16):2939-54. doi: 10.1091/mbc.E15-04-0247. Epub 2015 Jun 24.


Functional analysis of nuclear localization signals in VP1-2 homologues from all herpesvirus subfamilies.

Hennig T, Abaitua F, O'Hare P.

J Virol. 2014 May;88(10):5391-405. doi: 10.1128/JVI.03797-13. Epub 2014 Feb 26.


Polarized cell migration during cell-to-cell transmission of herpes simplex virus in human skin keratinocytes.

Abaitua F, Zia FR, Hollinshead M, O'Hare P.

J Virol. 2013 Jul;87(14):7921-32. doi: 10.1128/JVI.01172-13. Epub 2013 May 8.


A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore.

Abaitua F, Hollinshead M, Bolstad M, Crump CM, O'Hare P.

J Virol. 2012 Sep;86(17):8998-9014. doi: 10.1128/JVI.01209-12. Epub 2012 Jun 20.


Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein.

Guerra S, Abaitua F, Martínez-Sobrido L, Esteban M, García-Sastre A, Rodríguez D.

PLoS One. 2011;6(12):e28677. doi: 10.1371/journal.pone.0028677. Epub 2011 Dec 13.


Autocatalytic activity of the ubiquitin-specific protease domain of herpes simplex virus 1 VP1-2.

Bolstad M, Abaitua F, Crump CM, O'Hare P.

J Virol. 2011 Sep;85(17):8738-51. doi: 10.1128/JVI.00798-11. Epub 2011 Jun 29.


A single mutation responsible for temperature-sensitive entry and assembly defects in the VP1-2 protein of herpes simplex virus.

Abaitua F, Daikoku T, Crump CM, Bolstad M, O'Hare P.

J Virol. 2011 Mar;85(5):2024-36. doi: 10.1128/JVI.01895-10. Epub 2010 Dec 22.


Characterization of the herpes simplex virus (HSV)-1 tegument protein VP1-2 during infection with the HSV temperature-sensitive mutant tsB7.

Abaitua F, Souto RN, Browne H, Daikoku T, O'Hare P.

J Gen Virol. 2009 Oct;90(Pt 10):2353-2363. doi: 10.1099/vir.0.012492-0. Epub 2009 Jul 8.


Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1.

Roberts AP, Abaitua F, O'Hare P, McNab D, Rixon FJ, Pasdeloup D.

J Virol. 2009 Jan;83(1):105-16. doi: 10.1128/JVI.01032-08. Epub 2008 Oct 29.


Activation mechanism of a noncanonical RNA-dependent RNA polymerase.

Garriga D, Navarro A, Querol-Audí J, Abaitua F, Rodríguez JF, Verdaguer N.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20540-5. Epub 2007 Dec 11.


The 2.6-Angstrom structure of infectious bursal disease virus-derived T=1 particles reveals new stabilizing elements of the virus capsid.

Garriga D, Querol-Audí J, Abaitua F, Saugar I, Pous J, Verdaguer N, Castón JR, Rodriguez JF.

J Virol. 2006 Jul;80(14):6895-905.


Intracellular interference of infectious bursal disease virus.

González D, Rodríguez JF, Abaitua F.

J Virol. 2005 Nov;79(22):14437-41.


Improving recombinant MVA immune responses: potentiation of the immune responses to HIV-1 with MVA and DNA vectors expressing Env and the cytokines IL-12 and IFN-gamma.

Abaitua F, Rodríguez JR, Garzón A, Rodríguez D, Esteban M.

Virus Res. 2006 Mar;116(1-2):11-20. Epub 2005 Oct 7.


The oligomerization domain of VP3, the scaffolding protein of infectious bursal disease virus, plays a critical role in capsid assembly.

Maraver A, Oña A, Abaitua F, González D, Clemente R, Ruiz-Díaz JA, Castón JR, Pazos F, Rodriguez JF.

J Virol. 2003 Jun;77(11):6438-49.


In vitro survival and germination of Candida albicans in the presence of nitrogen compounds.

Abaitua F, Rementería A, Millan RS, Eguzkiza A, Rodriguez JA, Pontón J, Sevilla MJ.

Microbiology. 1999 Jul;145 ( Pt 7):1641-1647. doi: 10.1099/13500872-145-7-1641.


Resistance to candidiasis and macrophage activity in chitin-treated mice.

Rementería A, Abaitua F, García-Tobalina R, Hernando F, Pontón J, Sevilla MJ.

FEMS Immunol Med Microbiol. 1997 Nov;19(3):223-30.

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