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Items: 1 to 50 of 91

1.

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.

Kao LP, Morad SAF, Davis TS, MacDougall MR, Kassai M, Abdelmageed N, Fox TE, Kester M, Loughran TP Jr, Abad JL, Fabrias G, Tan SF, Feith DJ, Claxton DF, Spiegel S, Fisher-Wellman KH, Cabot MC.

J Lipid Res. 2019 Sep;60(9):1590-1602. doi: 10.1194/jlr.RA119000251. Epub 2019 Jul 30.

PMID:
31363040
2.

Rotational spectroscopy of organophosphorous chemical agents: cresyl and phenyl saligenin phosphates.

Saragi RT, Juanes M, Abad JL, Lesarri A, Pinacho R, Rubio JE.

Phys Chem Chem Phys. 2019 Aug 14;21(30):16418-16422. doi: 10.1039/c9cp03093j. Epub 2019 Jul 23.

PMID:
31332416
3.

Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells.

Crisostomo V, Baez C, Abad JL, Sanchez B, Alvarez V, Rosado R, Gómez-Mauricio G, Gheysens O, Blanco-Blazquez V, Blazquez R, Torán JL, Casado JG, Aguilar S, Janssens S, Sánchez-Margallo FM, Rodriguez-Borlado L, Bernad A, Palacios I.

Stem Cell Res Ther. 2019 May 31;10(1):152. doi: 10.1186/s13287-019-1237-6.

4.

Activity-Based Imaging of Acid Ceramidase in Living Cells.

Ordóñez YF, Abad JL, Aseeri M, Casas J, Garcia V, Casasampere M, Schuchman EH, Levade T, Delgado A, Triola G, Fabrias G.

J Am Chem Soc. 2019 May 15;141(19):7736-7742. doi: 10.1021/jacs.8b11687. Epub 2019 May 2.

PMID:
31030513
5.

New fluorogenic probes for neutral and alkaline ceramidases.

Casasampere M, Bielsa N, Riba D, Bassas L, Xu R, Mao C, Fabriàs G, Abad JL, Delgado A, Casas J.

J Lipid Res. 2019 Jun;60(6):1174-1181. doi: 10.1194/jlr.D092759. Epub 2019 Mar 29.

PMID:
30926626
6.

SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism.

Benson S, Fernandez A, Barth ND, de Moliner F, Horrocks MH, Herrington CS, Abad JL, Delgado A, Kelly L, Chang Z, Feng Y, Nishiura M, Hori Y, Kikuchi K, Vendrell M.

Angew Chem Int Ed Engl. 2019 May 20;58(21):6911-6915. doi: 10.1002/anie.201900465. Epub 2019 Apr 12.

7.

Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization.

Torán JL, López JA, Gomes-Alves P, Aguilar S, Torroja C, Trevisan-Herraz M, Moscoso I, Sebastião MJ, Serra M, Brito C, Cruz FM, Sepúlveda JC, Abad JL, Galán-Arriola C, Ibanez B, Martínez F, Fernández ME, Fernández-Aviles F, Palacios I, R-Borlado L, Vázquez J, Alves PM, Bernad A.

Sci Rep. 2019 Mar 15;9(1):4647. doi: 10.1038/s41598-019-39571-x.

8.

Azide-tagged sphingolipids for the proteome-wide identification of C16-ceramide-binding proteins.

Schulte-Zweckel J, Schneidewind T, Abad JL, Brockmeyer A, Janning P, Triola G.

Chem Commun (Camb). 2018 Dec 4;54(97):13742-13745. doi: 10.1039/c8cc05691a.

PMID:
30456403
9.

Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in cis-Ceramide Monolayers.

Fanani ML, Busto JV, Sot J, Abad JL, Fabrías G, Saiz L, Vilar JMG, Goñi FM, Maggio B, Alonso A.

Langmuir. 2018 Oct 2;34(39):11749-11758. doi: 10.1021/acs.langmuir.8b02198. Epub 2018 Sep 24.

PMID:
30183303
10.

Safety and Efficacy of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients With ST-Segment Elevation Myocardial Infarction and Left Ventricular Dysfunction.

Fernández-Avilés F, Sanz-Ruiz R, Bogaert J, Casado Plasencia A, Gilaberte I, Belmans A, Fernández-Santos ME, Charron D, Mulet M, Yotti R, Palacios I, Luque M, Sádaba R, San Román JA, Larman M, Sánchez PL, Sanchís J, Jiménez MF, Claus P, Al-Daccak R, Lombardo E, Abad JL, DelaRosa O, Corcóstegui L, Bermejo J, Janssens S.

Circ Res. 2018 Aug 17;123(5):579-589. doi: 10.1161/CIRCRESAHA.118.312823.

PMID:
29921651
11.

Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish.

Faria M, Fuertes I, Prats E, Abad JL, Padrós F, Gomez-Canela C, Casas J, Estevez J, Vilanova E, Piña B, Raldúa D.

Sci Rep. 2018 Mar 19;8(1):4844. doi: 10.1038/s41598-018-22977-4.

12.

Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.

Ordóñez-Gutiérrez L, Benito-Cuesta I, Abad JL, Casas J, Fábrias G, Wandosell F.

Pharm Res. 2018 Feb 6;35(3):49. doi: 10.1007/s11095-017-2312-2.

PMID:
29411122
13.

CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome.

Torán JL, Aguilar S, López JA, Torroja C, Quintana JA, Santiago C, Abad JL, Gomes-Alves P, Gonzalez A, Bernal JA, Jiménez-Borreguero LJ, Alves PM, R-Borlado L, Vázquez J, Bernad A.

Sci Rep. 2017 Oct 2;7(1):12490. doi: 10.1038/s41598-017-11976-6.

14.

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

Lopez-Santalla M, Mancheño-Corvo P, Escolano A, Menta R, DelaRosa O, Abad JL, Büscher D, Redondo JM, Bueren JA, Dalemans W, Lombardo E, Garin MI.

Front Immunol. 2017 Jun 8;8:638. doi: 10.3389/fimmu.2017.00638. eCollection 2017.

15.

Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.

Cingolani F, Simbari F, Abad JL, Casasampere M, Fabrias G, Futerman AH, Casas J.

J Lipid Res. 2017 Aug;58(8):1500-1513. doi: 10.1194/jlr.M072611. Epub 2017 Jun 1.

16.

Rotational spectra of tetracyclic quinolizidine alkaloids: does a water molecule flip sparteine?

Lesarri A, Pinacho R, Enríquez L, Rubio JE, Jaraíz M, Abad JL, Gigosos MA.

Phys Chem Chem Phys. 2017 Jul 21;19(27):17553-17559. doi: 10.1039/c7cp01432e. Epub 2017 May 5.

PMID:
28474045
17.

The first fluorogenic sensor for sphingosine-1-phosphate lyase activity in intact cells.

Sanllehí P, Casasampere M, Abad JL, Fabriàs G, López O, Bujons J, Casas J, Delgado A.

Chem Commun (Camb). 2017 May 11;53(39):5441-5444. doi: 10.1039/c7cc01659j.

PMID:
28462976
18.

Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism.

Calderón R, Mercadal N, Abad JL, Ariza X, Delgado A, Garcia J, Rodríguez A, Fabriàs G.

Chem Phys Lipids. 2017 Jun;205:34-41. doi: 10.1016/j.chemphyslip.2017.04.008. Epub 2017 Apr 23.

19.

Inhibitors of ceramide de novo biosynthesis rescue damages induced by cigarette smoke in airways epithelia.

Zulueta A, Caretti A, Campisi GM, Brizzolari A, Abad JL, Paroni R, Signorelli P, Ghidoni R.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jul;390(7):753-759. doi: 10.1007/s00210-017-1375-2. Epub 2017 Apr 13.

PMID:
28409208
20.

From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor.

Pou A, Abad JL, Ordóñez YF, Garrido M, Casas J, Fabriàs G, Delgado A.

Chem Commun (Camb). 2017 Apr 13;53(31):4394-4397. doi: 10.1039/c6cc08268h.

PMID:
28379228
21.

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization.

Hernández-Tiedra S, Fabriàs G, Dávila D, Salanueva ÍJ, Casas J, Montes LR, Antón Z, García-Taboada E, Salazar-Roa M, Lorente M, Nylandsted J, Armstrong J, López-Valero I, McKee CS, Serrano-Puebla A, García-López R, González-Martínez J, Abad JL, Hanada K, Boya P, Goñi F, Guzmán M, Lovat P, Jäättelä M, Alonso A, Velasco G.

Autophagy. 2016 Nov;12(11):2213-2229. Epub 2016 Sep 16.

22.

Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates.

Sanllehí P, Abad JL, Bujons J, Casas J, Delgado A.

Eur J Med Chem. 2016 Nov 10;123:905-915. doi: 10.1016/j.ejmech.2016.08.008. Epub 2016 Aug 6.

PMID:
27543882
23.

Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors.

Sanllehí P, Abad JL, Casas J, Bujons J, Delgado A.

Bioorg Med Chem. 2016 Sep 15;24(18):4381-4389. doi: 10.1016/j.bmc.2016.07.033. Epub 2016 Jul 18.

PMID:
27475537
24.

Abiotic amidine and guanidine hydrolysis of lamotrigine-N2-glucuronide and related compounds in wastewater: The role of pH and N2-substitution on reaction kinetics.

Zonja B, Delgado A, Abad JL, Pérez S, Barceló D.

Water Res. 2016 Sep 1;100:466-475. doi: 10.1016/j.watres.2016.04.072. Epub 2016 May 3.

PMID:
27232991
25.

3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells.

Ordóñez YF, González J, Bedia C, Casas J, Abad JL, Delgado A, Fabrias G.

Mol Biosyst. 2016 Apr;12(4):1166-73. doi: 10.1039/c5mb00852b. Epub 2016 Mar 1.

PMID:
26928714
26.

Investigating the formation and toxicity of nitrogen transformation products of diclofenac and sulfamethoxazole in wastewater treatment plants.

Osorio V, Sanchís J, Abad JL, Ginebreda A, Farré M, Pérez S, Barceló D.

J Hazard Mater. 2016 May 15;309:157-64. doi: 10.1016/j.jhazmat.2016.02.013. Epub 2016 Feb 8.

PMID:
26894288
27.

Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.

Casasampere M, Camacho L, Cingolani F, Casas J, Egido-Gabás M, Abad JL, Bedia C, Xu R, Wang K, Canals D, Hannun YA, Mao C, Fabrias G.

J Lipid Res. 2015 Oct;56(10):2019-28. doi: 10.1194/jlr.D061564. Epub 2015 Aug 18. Erratum in: J Lipid Res. 2016 Aug;57(8):1598.

28.

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase).

Sanllehí P, Abad JL, Casas J, Delgado A.

Chem Phys Lipids. 2016 May;197:69-81. doi: 10.1016/j.chemphyslip.2015.07.007. Epub 2015 Jul 19. Review.

PMID:
26200919
29.

Delayed administration of allogeneic cardiac stem cell therapy for acute myocardial infarction could ameliorate adverse remodeling: experimental study in swine.

Crisostomo V, Baez-Diaz C, Maestre J, Garcia-Lindo M, Sun F, Casado JG, Blazquez R, Abad JL, Palacios I, Rodriguez-Borlado L, Sanchez-Margallo FM.

J Transl Med. 2015 May 12;13:156. doi: 10.1186/s12967-015-0512-2.

30.

Azide-tagged sphingolipids: new tools for metabolic flux analysis.

Garrido M, Abad JL, Fabriàs G, Casas J, Delgado A.

Chembiochem. 2015 Mar 2;16(4):641-50. doi: 10.1002/cbic.201402649. Epub 2015 Feb 11.

PMID:
25676480
31.

Fluorescent polyene ceramide analogues as membrane probes.

Nieves I, Artetxe I, Abad JL, Alonso A, Busto JV, Fajarí L, Montes LR, Sot J, Delgado A, Goñi FM.

Langmuir. 2015 Mar 3;31(8):2484-92. doi: 10.1021/la505017x. Epub 2015 Feb 19.

PMID:
25658138
32.

Structure elucidation of phototransformation products of unapproved analogs of the erectile dysfunction drug sildenafil in artificial freshwater with UPLC-Q Exactive-MS.

Aceña J, Pérez S, Gardinali P, Abad JL, Eichhorn P, Heuett N, Barceló D.

J Mass Spectrom. 2014 Dec;49(12):1279-89. doi: 10.1002/jms.3461.

PMID:
25476946
33.

Simultaneous determination of diclofenac, its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry.

Osorio V, Imbert-Bouchard M, Zonja B, Abad JL, Pérez S, Barceló D.

J Chromatogr A. 2014 Jun 20;1347:63-71. doi: 10.1016/j.chroma.2014.04.058. Epub 2014 Apr 24.

PMID:
24835592
34.

Microcharacterization of a natural blue pigment used in wall paintings during the Romanesque period in northern Spain.

Pérez-Arantegui J, Pardos C, Abad JL, García JR.

Microsc Microanal. 2013 Dec;19(6):1645-52. doi: 10.1017/S1431927613013391. Epub 2013 Sep 4.

PMID:
24001355
35.

Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells.

Abad JL, Nieves I, Rayo P, Casas J, Fabriàs G, Delgado A.

J Org Chem. 2013 Jun 21;78(12):5858-66. doi: 10.1021/jo400440z. Epub 2013 May 30.

PMID:
23679346
36.

In situ synthesis of fluorescent membrane lipids (ceramides) using click chemistry.

Garrido M, Abad JL, Alonso A, Goñi FM, Delgado A, Montes LR.

J Chem Biol. 2012 Apr 18;5(3):119-23. doi: 10.1007/s12154-012-0075-0. Print 2012 Jul.

37.

Acid ceramidase as a therapeutic target in metastatic prostate cancer.

Camacho L, Meca-Cortés O, Abad JL, García S, Rubio N, Díaz A, Celià-Terrassa T, Cingolani F, Bermudo R, Fernández PL, Blanco J, Delgado A, Casas J, Fabriàs G, Thomson TM.

J Lipid Res. 2013 May;54(5):1207-20. doi: 10.1194/jlr.M032375. Epub 2013 Feb 19.

38.

Natural products as platforms for the design of sphingolipid-related anticancer agents.

Delgado A, Fabriàs G, Casas J, Abad JL.

Adv Cancer Res. 2013;117:237-81. doi: 10.1016/B978-0-12-394274-6.00008-X. Review.

PMID:
23290782
39.

Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.

Gagliostro V, Casas J, Caretti A, Abad JL, Tagliavacca L, Ghidoni R, Fabrias G, Signorelli P.

Int J Biochem Cell Biol. 2012 Dec;44(12):2135-43. doi: 10.1016/j.biocel.2012.08.025. Epub 2012 Sep 7.

PMID:
22960157
40.

Cellular changes that accompany shedding of human corneocytes.

Lin TK, Crumrine D, Ackerman LD, Santiago JL, Roelandt T, Uchida Y, Hupe M, Fabriàs G, Abad JL, Rice RH, Elias PM.

J Invest Dermatol. 2012 Oct;132(10):2430-2439. doi: 10.1038/jid.2012.173. Epub 2012 Jun 28.

41.

Identification of phototransformation products of sildenafil (Viagra) and its N-demethylated human metabolite under simulated sunlight.

Eichhorn P, Pérez S, Aceña J, Gardinali P, Abad JL, Barceló D.

J Mass Spectrom. 2012 Jun;47(6):701-11. doi: 10.1002/jms.2998.

PMID:
22707162
42.

3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate.

Camacho L, Simbari F, Garrido M, Abad JL, Casas J, Delgado A, Fabriàs G.

Bioorg Med Chem. 2012 May 15;20(10):3173-9. doi: 10.1016/j.bmc.2012.03.073. Epub 2012 Apr 6.

PMID:
22537678
43.

C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.

Flowers M, Fabriás G, Delgado A, Casas J, Abad JL, Cabot MC.

Breast Cancer Res Treat. 2012 Jun;133(2):447-58. doi: 10.1007/s10549-011-1768-8. Epub 2011 Sep 21.

PMID:
21935601
44.

Sphingolipid modulation: a strategy for cancer therapy.

Delgado A, Fabrias G, Bedia C, Casas J, Abad JL.

Anticancer Agents Med Chem. 2012 May;12(4):285-302. Review.

PMID:
21864240
45.

Ceramidases in hematological malignancies: senseless or neglected target?

Fabrias G, Bedia C, Casas J, Abad JL, Delgado A.

Anticancer Agents Med Chem. 2011 Nov;11(9):830-43. Review.

PMID:
21707488
46.

Pseudomonas keratitis 4 years after laser in situ keratomileusis.

Ferrer C, Rodriguez-Prats JL, Abad JL, Claramonte P, Alió JL, Signes-Soler I.

Optom Vis Sci. 2011 Oct;88(10):1252-4. doi: 10.1097/OPX.0b013e318223c0c4.

PMID:
21666521
47.

A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease.

Bedia C, Camacho L, Abad JL, Fabriàs G, Levade T.

J Lipid Res. 2010 Dec;51(12):3542-7. doi: 10.1194/jlr.D010033. Epub 2010 Sep 24.

48.

The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate.

Méndez-Gómez HR, Vergaño-Vera E, Abad JL, Bulfone A, Moratalla R, de Pablo F, Vicario-Abejón C.

Mol Cell Neurosci. 2011 Jan;46(1):108-21. doi: 10.1016/j.mcn.2010.08.011. Epub 2010 Aug 31.

PMID:
20807572
49.

Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains.

Vieira CR, Munoz-Olaya JM, Sot J, Jiménez-Baranda S, Izquierdo-Useros N, Abad JL, Apellániz B, Delgado R, Martinez-Picado J, Alonso A, Casas J, Nieva JL, Fabriás G, Mañes S, Goñi FM.

Chem Biol. 2010 Jul 30;17(7):766-75. doi: 10.1016/j.chembiol.2010.05.023.

50.

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.

Gangoiti P, Camacho L, Arana L, Ouro A, Granado MH, Brizuela L, Casas J, Fabriás G, Abad JL, Delgado A, Gómez-Muñoz A.

Prog Lipid Res. 2010 Oct;49(4):316-34. doi: 10.1016/j.plipres.2010.02.004. Epub 2010 Mar 1. Review.

PMID:
20193711

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