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Detection of genetic cardiac diseases by Ca2+ transient profiles using machine learning methods.

Juhola M, Joutsijoki H, Penttinen K, Aalto-Setälä K.

Sci Rep. 2018 Jun 19;8(1):9355. doi: 10.1038/s41598-018-27695-5.


Human inducible pluripotent stem cell-derived sensory neurons express multiple functional ion channels and GPCRs.

Saarnilehto M, Pekkanen-Mattila M, Aalto-Setälä K, Silvennoinen O, Koivisto A.

Scand J Pain. 2017 Dec 29;4(4):260. doi: 10.1016/j.sjpain.2013.07.017.


Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients.

Pölönen RP, Penttinen K, Swan H, Aalto-Setälä K.

Stem Cells Int. 2018 Apr 12;2018:9109503. doi: 10.1155/2018/9109503. eCollection 2018.


A Portable Microscale Cell Culture System with Indirect Temperature Control.

Mäki AJ, Verho J, Kreutzer J, Ryynänen T, Rajan D, Pekkanen-Mattila M, Ahola A, Hyttinen J, Aalto-Setälä K, Lekkala J, Kallio P.

SLAS Technol. 2018 Apr 1:2472630318768710. doi: 10.1177/2472630318768710. [Epub ahead of print]


Age Is Relative-Impact of Donor Age on Induced Pluripotent Stem Cell-Derived Cell Functionality.

Strässler ET, Aalto-Setälä K, Kiamehr M, Landmesser U, Kränkel N.

Front Cardiovasc Med. 2018 Jan 25;5:4. doi: 10.3389/fcvm.2018.00004. eCollection 2018. Review.


Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy.

Prajapati C, Ojala M, Aalto-Setälä K.

Dis Model Mech. 2018 Feb 26;11(2). pii: dmm032896. doi: 10.1242/dmm.032896.


Simultaneous Measurement of Contraction and Calcium Transients in Stem Cell Derived Cardiomyocytes.

Ahola A, Pölönen RP, Aalto-Setälä K, Hyttinen J.

Ann Biomed Eng. 2018 Jan;46(1):148-158. doi: 10.1007/s10439-017-1933-2. Epub 2017 Oct 3.


Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.

Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K.

Dis Model Mech. 2017 Sep 1;10(9):1141-1153. doi: 10.1242/dmm.030841. Epub 2017 Jul 21.


Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes.

Kuusela J, Larsson K, Shah D, Prajapati C, Aalto-Setälä K.

Biol Open. 2017 Jun 15;6(6):777-784. doi: 10.1242/bio.024216.


Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct.

Vuorenpää H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setälä K.

Cytotechnology. 2017 Oct;69(5):785-800. doi: 10.1007/s10616-017-0088-1. Epub 2017 Apr 10.


Electrocardiogram changes and atrial arrhythmias in individuals carrying sodium channel SCN5A D1275N mutation.

Vanninen SUM, Nikus K, Aalto-Setälä K.

Ann Med. 2017 Sep;49(6):496-503. doi: 10.1080/07853890.2017.1307515. Epub 2017 Apr 17.


Error-Correcting Output Codes in Classification of Human Induced Pluripotent Stem Cell Colony Images.

Joutsijoki H, Haponen M, Rasku J, Aalto-Setälä K, Juhola M.

Biomed Res Int. 2016;2016:3025057. Epub 2016 Oct 26.


The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes.

Kuusela J, Kim J, Räsänen E, Aalto-Setälä K.

Stem Cell Rev. 2016 Dec;12(6):698-707.


Machine Learning Approach to Automated Quality Identification of Human Induced Pluripotent Stem Cell Colony Images.

Joutsijoki H, Haponen M, Rasku J, Aalto-Setälä K, Juhola M.

Comput Math Methods Med. 2016;2016:3091039. doi: 10.1155/2016/3091039. Epub 2016 Jul 14.


Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy.

Ojala M, Prajapati C, Pölönen RP, Rajala K, Pekkanen-Mattila M, Rasku J, Larsson K, Aalto-Setälä K.

Stem Cells Int. 2016;2016:1684792. doi: 10.1155/2016/1684792. Epub 2015 Dec 28.


Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes.

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setälä K.

Springerplus. 2016 Feb 29;5:234. doi: 10.1186/s40064-016-1889-y. eCollection 2016.


Methods for in vitro functional analysis of iPSC derived cardiomyocytes - Special focus on analyzing the mechanical beating behavior.

Laurila E, Ahola A, Hyttinen J, Aalto-Setälä K.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1864-72. doi: 10.1016/j.bbamcr.2015.12.013. Epub 2015 Dec 18. Review.


Slowed depolarization and irregular repolarization in catecholaminergic polymorphic ventricular tachycardia: a study from cellular Ca2+ transients and action potentials to clinical monophasic action potentials and electrocardiography.

Paavola J, Väänänen H, Larsson K, Penttinen K, Toivonen L, Kontula K, Laine M, Aalto-Setälä K, Swan H, Viitasalo M.

Europace. 2016 Oct;18(10):1599-1607. Epub 2015 Dec 24.


CytoSpectre: a tool for spectral analysis of oriented structures on cellular and subcellular levels.

Kartasalo K, Pölönen RP, Ojala M, Rasku J, Lekkala J, Aalto-Setälä K, Kallio P.

BMC Bioinformatics. 2015 Oct 26;16:344. doi: 10.1186/s12859-015-0782-y.


A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production.

Manzini S, Viiri LE, Marttila S, Aalto-Setälä K.

Stem Cell Rev. 2015 Dec;11(6):900-8. doi: 10.1007/s12015-015-9619-3.


Novel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes.

Penttinen K, Siirtola H, Àvalos-Salguero J, Vainio T, Juhola M, Aalto-Setälä K.

PLoS One. 2015 Aug 26;10(8):e0135806. doi: 10.1371/journal.pone.0135806. eCollection 2015.


Correction: Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K.

PLoS One. 2015 Jul 31;10(7):e0134746. doi: 10.1371/journal.pone.0134746. eCollection 2015. No abstract available.


Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K.

PLoS One. 2015 May 8;10(5):e0125366. doi: 10.1371/journal.pone.0125366. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134746.


Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations.

Kiviaho AL, Ahola A, Larsson K, Penttinen K, Swan H, Pekkanen-Mattila M, Venäläinen H, Paavola K, Hyttinen J, Aalto-Setälä K.

Int J Cardiol Heart Vasc. 2015 Apr 25;8:19-31. doi: 10.1016/j.ijcha.2015.04.008. eCollection 2015 Sep 1.


Signal analysis and classification methods for the calcium transient data of stem cell-derived cardiomyocytes.

Juhola M, Penttinen K, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Siirtola H, Iltanen K, Laurikkala J, Hyyrö H, Hyttinen J, Aalto-Setälä K.

Comput Biol Med. 2015 Jun;61:1-7. doi: 10.1016/j.compbiomed.2015.03.016. Epub 2015 Mar 24.


Investigating local spatially-enhanced structural and textural descriptors for classification of iPSC colony images.

Gizatdinova Y, Rasku J, Haponen M, Joutsijoki H, Baldin I, Paci M, Hyttinen J, Aalto-Setälä K, Juhola M.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:3361-5. doi: 10.1109/EMBC.2014.6944343.


On computation of calcium cycling anomalies in cardiomyocytes data.

Juhola M, Joutsijoki H, Varpa K, Saarikoski J, Rasku J, Iltanen K, Laurikkala J, Hyyrö H, Avalos-Salguero J, Siirtola H, Penttinen K, Aalto-Setälä K.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:1444-7. doi: 10.1109/EMBC.2014.6943872.


[Beating heart cells--targeted diagnostics, individual optimization of therapy and tailored cell therapies].

Kankuri E, Harjula A, Pätilä T, Penttinen K, Aalto-Setälä K.

Duodecim. 2014;130(19):2001-8. Review. Finnish.


Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.

Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR.

Stem Cell Reports. 2014 Aug 12;3(2):269-81. doi: 10.1016/j.stemcr.2014.06.003. Epub 2014 Jul 4.


A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy.

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Kärkkäinen S, Peuhkurinen K, Nieminen MS, Laakso M; FinHCM Study Group, Kuusisto J.

Ann Med. 2014 Sep;46(6):424-9. doi: 10.3109/07853890.2014.912834. Epub 2014 Jun 3.


Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation.

Ahola A, Kiviaho AL, Larsson K, Honkanen M, Aalto-Setälä K, Hyttinen J.

Biomed Eng Online. 2014 Apr 7;13:39. doi: 10.1186/1475-925X-13-39.


Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes.

Vuorenpää H, Ikonen L, Kujala K, Huttala O, Sarkanen JR, Ylikomi T, Aalto-Setälä K, Heinonen T.

In Vitro Cell Dev Biol Anim. 2014 Apr;50(4):275-86. doi: 10.1007/s11626-013-9703-4. Epub 2013 Oct 26.


Pneumatic cell stretching system for cardiac differentiation and culture.

Kreutzer J, Ikonen L, Hirvonen J, Pekkanen-Mattila M, Aalto-Setälä K, Kallio P.

Med Eng Phys. 2014 Apr;36(4):496-501. doi: 10.1016/j.medengphy.2013.09.008. Epub 2013 Oct 19.


Cardiomyocyte MEA data analysis (CardioMDA)--a novel field potential data analysis software for pluripotent stem cell derived cardiomyocytes.

Pradhapan P, Kuusela J, Viik J, Aalto-Setälä K, Hyttinen J.

PLoS One. 2013 Sep 19;8(9):e73637. doi: 10.1371/journal.pone.0073637. eCollection 2013.


Computational models of ventricular- and atrial-like human induced pluripotent stem cell derived cardiomyocytes.

Paci M, Hyttinen J, Aalto-Setälä K, Severi S.

Ann Biomed Eng. 2013 Nov;41(11):2334-48. doi: 10.1007/s10439-013-0833-3. Epub 2013 May 31.


Electrical Field Stimulation with a Novel Platform: Effect on Cardiomyocyte Gene Expression but not on Orientation.

Kujala K, Ahola A, Pekkanen-Mattila M, Ikonen L, Kerkelä E, Hyttinen J, Aalto-Setälä K.

Int J Biomed Sci. 2012 Jun;8(2):109-20.


2D and 3D self-assembling nanofiber hydrogels for cardiomyocyte culture.

Ikonen L, Kerkelä E, Metselaar G, Stuart MC, de Jong MR, Aalto-Setälä K.

Biomed Res Int. 2013;2013:285678. doi: 10.1155/2013/285678. Epub 2012 Dec 31.


Comparative analysis of targeted differentiation of human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells reveals variability associated with incomplete transgene silencing in retrovirally derived hiPSC lines.

Toivonen S, Ojala M, Hyysalo A, Ilmarinen T, Rajala K, Pekkanen-Mattila M, Äänismaa R, Lundin K, Palgi J, Weltner J, Trokovic R, Silvennoinen O, Skottman H, Narkilahti S, Aalto-Setälä K, Otonkoski T.

Stem Cells Transl Med. 2013 Feb;2(2):83-93. doi: 10.5966/sctm.2012-0047. Epub 2013 Jan 22.


Culture conditions affect cardiac differentiation potential of human pluripotent stem cells.

Ojala M, Rajala K, Pekkanen-Mattila M, Miettinen M, Huhtala H, Aalto-Setälä K.

PLoS One. 2012;7(10):e48659. doi: 10.1371/journal.pone.0048659. Epub 2012 Oct 31.


Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.

Kujala K, Paavola J, Lahti A, Larsson K, Pekkanen-Mattila M, Viitasalo M, Lahtinen AM, Toivonen L, Kontula K, Swan H, Laine M, Silvennoinen O, Aalto-Setälä K.

PLoS One. 2012;7(9):e44660. doi: 10.1371/journal.pone.0044660. Epub 2012 Sep 4.


Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population.

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Nieminen MS, Laakso M, Kuusisto J; FinHCM study group, Kervinen H, Mustonen J, Juvonen J, Niemi M, Uusimaa P, Huttunen M, Kotila M, Pietilä M.

Ann Med. 2013 Feb;45(1):85-90. doi: 10.3109/07853890.2012.671534. Epub 2012 Apr 2.


The effect of human and mouse fibroblast feeder cells on cardiac differentiation of human pluripotent stem cells.

Pekkanen-Mattila M, Ojala M, Kerkelä E, Rajala K, Skottman H, Aalto-Setälä K.

Stem Cells Int. 2012;2012:875059. doi: 10.1155/2012/875059. Epub 2012 Jan 19.


Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K.

Dis Model Mech. 2012 Mar;5(2):220-30. doi: 10.1242/dmm.008409. Epub 2011 Nov 3.


Averaging in vitro cardiac field potential recordings obtained with microelectrode arrays.

Kujala VJ, Jimenez ZC, Väisänen J, Tanskanen JM, Kerkelä E, Hyttinen J, Aalto-Setälä K.

Comput Methods Programs Biomed. 2011 Nov;104(2):199-205. doi: 10.1016/j.cmpb.2011.04.001. Epub 2011 Jun 8.


Cardiac differentiation of pluripotent stem cells.

Rajala K, Pekkanen-Mattila M, Aalto-Setälä K.

Stem Cells Int. 2011;2011:383709. doi: 10.4061/2011/383709. Epub 2011 Apr 4.


[Genetic testing in cardiologic diagnostics].

Heliö T, Aalto-Setälä K.

Duodecim. 2010;126(14):1685-92. Review. Finnish.


A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells.

Rajala K, Lindroos B, Hussein SM, Lappalainen RS, Pekkanen-Mattila M, Inzunza J, Rozell B, Miettinen S, Narkilahti S, Kerkelä E, Aalto-Setälä K, Otonkoski T, Suuronen R, Hovatta O, Skottman H.

PLoS One. 2010 Apr 19;5(4):e10246. doi: 10.1371/journal.pone.0010246.


Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype.

Pekkanen-Mattila M, Chapman H, Kerkelä E, Suuronen R, Skottman H, Koivisto AP, Aalto-Setälä K.

Exp Biol Med (Maywood). 2010 Apr;235(4):522-30. doi: 10.1258/ebm.2010.009345.


Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies.

Pekkanen-Mattila M, Pelto-Huikko M, Kujala V, Suuronen R, Skottman H, Aalto-Setälä K, Kerkelä E.

Histochem Cell Biol. 2010 May;133(5):595-606. doi: 10.1007/s00418-010-0689-7. Epub 2010 Apr 6.


Obtaining consent for future research with induced pluripotent cells: opportunities and challenges.

Aalto-Setälä K, Conklin BR, Lo B.

PLoS Biol. 2009 Feb 24;7(2):e42. doi: 10.1371/journal.pbio.1000042. No abstract available.

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