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Items: 1 to 50 of 237

1.

Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine.

Staehr C, Rajanathan R, Postnov DD, Hangaard L, Bouzinova EV, Lykke-Hartmann K, Bach FW, Sandow SL, Aalkjaer C, Matchkov VV.

Cardiovasc Res. 2019 Nov 9. pii: cvz306. doi: 10.1093/cvr/cvz306. [Epub ahead of print]

PMID:
31710670
2.

Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo.

Saxton SN, Withers SB, Nyvad J, Mazur A, Matchkov V, Heagerty AM, Aalkjær C.

J Vasc Res. 2019;56(6):320-332. doi: 10.1159/000502689. Epub 2019 Sep 24.

PMID:
31550717
3.

[Ca2+ ] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries-Relation to noradrenaline release and contraction.

Hansen T, Tarasova OS, Khammy MM, Ferreira A, Kennard JA, Andresen J, Staehr C, Brain KL, Nilsson H, Aalkjaer C.

Acta Physiol (Oxf). 2019 Aug;226(4):e13279. doi: 10.1111/apha.13279. Epub 2019 Apr 26.

PMID:
30957955
4.

Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease: Diagnostic and Additional Therapeutic Consequences.

De Mey JGR, Bloksgaard M, Aalkjær C.

Physiology (Bethesda). 2019 Mar 1;34(2):82-83. doi: 10.1152/physiol.00053.2018. No abstract available.

PMID:
30724126
5.

Rat mesenteric small artery neurogenic dilatation is predominantly mediated by β1 -adrenoceptors in vivo.

Søndergaard AM, Overgaard CB, Mazur A, Postnov DD, Matchkov VV, Aalkjaer C.

J Physiol. 2019 Apr;597(7):1819-1831. doi: 10.1113/JP277368. Epub 2019 Feb 21.

PMID:
30693527
6.

The vasodilating effect of glucose differs among vessels at different branching level in the porcine retina ex vivo.

Jensen PS, Aalkjaer C, Bek T.

Exp Eye Res. 2019 Feb;179:150-156. doi: 10.1016/j.exer.2018.11.006. Epub 2018 Nov 10.

PMID:
30419216
7.

The Na,K-ATPase-Dependent Src Kinase Signaling Changes with Mesenteric Artery Diameter.

Zhang L, Aalkjaer C, Matchkov VV.

Int J Mol Sci. 2018 Aug 23;19(9). pii: E2489. doi: 10.3390/ijms19092489.

8.

Smooth muscle Ca2+ sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation.

Staehr C, Hangaard L, Bouzinova EV, Kim S, Rajanathan R, Boegh Jessen P, Luque N, Xie Z, Lykke-Hartmann K, Sandow SL, Aalkjaer C, Matchkov VV.

J Cereb Blood Flow Metab. 2019 Aug;39(8):1570-1587. doi: 10.1177/0271678X18761712. Epub 2018 Mar 7.

PMID:
29513112
9.

The α2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc-dependent Ca2+ sensitization.

Bouzinova EV, Hangaard L, Staehr C, Mazur A, Ferreira A, Chibalin AV, Sandow SL, Xie Z, Aalkjaer C, Matchkov VV.

Acta Physiol (Oxf). 2018 Sep;224(1):e13059. doi: 10.1111/apha.13059. Epub 2018 Mar 25. Erratum in: Acta Physiol (Oxf). 2019 Sep;227(1):e13343.

PMID:
29480968
10.

Variable Contribution of TMEM16A to Tone in Murine Arterial Vasculature.

Jensen AB, Joergensen HB, Dam VS, Kamaev D, Boedtkjer D, Füchtbauer EM, Aalkjaer C, Matchkov VV.

Basic Clin Pharmacol Toxicol. 2018 Jul;123(1):30-41. doi: 10.1111/bcpt.12984. Epub 2018 Mar 30.

11.

Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle.

Lindman J, Khammy MM, Lundegaard PR, Aalkjær C, Jepps TA.

Hypertension. 2018 Feb;71(2):336-345. doi: 10.1161/HYPERTENSIONAHA.117.10152. Epub 2017 Dec 26.

PMID:
29279314
12.

The ins and outs of acid-base transport in skeletal muscle.

Aalkjær C, Nielsen OB.

J Gen Physiol. 2018 Jan 2;150(1):3-6. doi: 10.1085/jgp.201711955. Epub 2017 Dec 13. No abstract available.

13.

Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome.

Thorsen K, Dam VS, Kjaer-Sorensen K, Pedersen LN, Skeberdis VA, Jurevičius J, Treinys R, Petersen IMBS, Nielsen MS, Oxvig C, Morth JP, Matchkov VV, Aalkjær C, Bundgaard H, Jensen HK.

Nat Commun. 2017 Nov 22;8(1):1696. doi: 10.1038/s41467-017-01630-0.

14.

4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries.

Khammy MM, Kim S, Bentzen BH, Lee S, Choi I, Aalkjaer C, Jepps TA.

Br J Pharmacol. 2018 Feb;175(3):501-516. doi: 10.1111/bph.14097. Epub 2018 Jan 5.

15.

Reply from Vladimir V. Matchkov and Christian Aalkjaer.

Matchkov VV, Aalkjaer C.

J Physiol. 2017 Nov 1;595(21):6785-6787. doi: 10.1113/JP275145. No abstract available.

16.

The crystal structure of the regulatory domain of the human sodium-driven chloride/bicarbonate exchanger.

Alvadia CM, Sommer T, Bjerregaard-Andersen K, Damkier HH, Montrasio M, Aalkjaer C, Morth JP.

Sci Rep. 2017 Sep 21;7(1):12131. doi: 10.1038/s41598-017-12409-0.

17.

ACCURACY OF NONINVASIVE ANESTHETIC MONITORING IN THE ANESTHETIZED GIRAFFE (GIRAFFA CAMELOPARDALIS).

Bertelsen MF, Grøndahl C, Stegmann GF, Sauer C, Secher NH, Hasenkam JM, Damkjær M, Aalkjær C, Wang T.

J Zoo Wildl Med. 2017 Sep;48(3):609-615. doi: 10.1638/2016-0276.1.

PMID:
28920806
18.

PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

Khammy MM, Dalsgaard T, Larsen PH, Christoffersen CT, Clausen D, Rasmussen LK, Folkersen L, Grunnet M, Kehler J, Aalkjaer C, Nielsen J.

Br J Pharmacol. 2017 Nov;174(22):4186-4198. doi: 10.1111/bph.14034. Epub 2017 Oct 15.

19.

Down-regulation of KCa2.3 channels causes erectile dysfunction in mice.

Comerma-Steffensen S, Kun A, Hedegaard ER, Mogensen S, Aalkjaer C, Köhler R, Mønster Christensen B, Simonsen U.

Sci Rep. 2017 Jun 19;7(1):3839. doi: 10.1038/s41598-017-04188-5.

20.

Cardiac heterogeneity and drug-provoked arrhythmias.

Ravens U, Aalkjaer C.

Acta Physiol (Oxf). 2017 Nov;221(3):157-159. doi: 10.1111/apha.12907. Epub 2017 Jul 10. No abstract available.

PMID:
28613434
21.

Intravital investigation of rat mesenteric small artery tone and blood flow.

Nyvad J, Mazur A, Postnov DD, Straarup MS, Soendergaard AM, Staehr C, Brøndum E, Aalkjaer C, Matchkov VV.

J Physiol. 2017 Aug 1;595(15):5037-5053. doi: 10.1113/JP274604. Epub 2017 Jun 30.

22.

Differential effects of nitric oxide and cyclo-oxygenase inhibition on the diameter of porcine retinal vessels with different caliber during hypoxia ex vivo.

Skov Jensen P, Aalkjaer C, Bek T.

Exp Eye Res. 2017 Jul;160:38-44. doi: 10.1016/j.exer.2017.04.001. Epub 2017 Apr 7.

PMID:
28395971
23.

Spontaneous and Evoked Contractility of Human Intestinal Lymphatic Vessels.

Telinius N, Majgaard J, Mohanakumar S, Pahle E, Nielsen J, Hjortdal V, Aalkjær C, Boedtkjer DB.

Lymphat Res Biol. 2017 Mar;15(1):17-22. doi: 10.1089/lrb.2016.0039. Epub 2017 Mar 9.

PMID:
28277905
24.

Na-K-ATPase regulates intercellular communication in the vascular wall via cSrc kinase-dependent connexin43 phosphorylation.

Hangaard L, Bouzinova EV, Staehr C, Dam VS, Kim S, Xie Z, Aalkjaer C, Matchkov VV.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C385-C397. doi: 10.1152/ajpcell.00347.2016. Epub 2017 Jan 25.

25.

Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.

Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ, Ye S.

Hum Mol Genet. 2017 Mar 1;26(5):989-1002. doi: 10.1093/hmg/ddx015.

26.

Long chain n-3 polyunsaturated fatty acids and vascular function in patients with chronic kidney disease and healthy subjects: a cross-sectional and comparative study.

Borg M, Svensson M, Povlsen JV, Schmidt EB, Aalkjær C, Christensen JH, Ivarsen P.

BMC Nephrol. 2016 Nov 21;17(1):184.

27.

GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.

Egholm C, Khammy MM, Dalsgaard T, Mazur A, Tritsaris K, Hansen AJ, Aalkjaer C, Dissing S.

Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1214-H1224. doi: 10.1152/ajpheart.00316.2016. Epub 2016 Sep 16.

28.

Negative News: Cl- and HCO3- in the Vascular Wall.

Boedtkjer E, Matchkov VV, Boedtkjer DM, Aalkjaer C.

Physiology (Bethesda). 2016 Sep;31(5):370-83. doi: 10.1152/physiol.00001.2016. Review.

29.

Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling.

Boedtkjer E, Bentzon JF, Dam VS, Aalkjaer C.

Cardiovasc Res. 2016 Aug 1;111(3):227-39. doi: 10.1093/cvr/cvw079. Epub 2016 Apr 13.

PMID:
27076468
30.

The vasodilating effects of insulin and lactate are increased in precapillary arterioles in the porcine retina ex vivo.

Skov Jensen P, Metz Mariendal Pedersen S, Aalkjaer C, Bek T.

Acta Ophthalmol. 2016 Aug;94(5):454-62. doi: 10.1111/aos.13025. Epub 2016 Mar 24.

31.

Sensitivity to the thromboxane A2 analog U46619 varies with inner diameter in human stem villous arteries.

Broegger T, Andersson KE, Aalkjaer C, Forman A, Boedtkjer DB.

Placenta. 2016 Mar;39:111-5. doi: 10.1016/j.placenta.2016.01.017. Epub 2016 Jan 22.

PMID:
26992683
32.

Tone regulation in giraffe retinal arterioles.

Telinius N, Brøgger T, Skovgaard N, Bek T, Aalkjaer C.

Acta Ophthalmol. 2016 Sep;94(6):e523-4. doi: 10.1111/aos.12958. Epub 2016 Jan 25. No abstract available.

33.

Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ.

Boedtkjer E, Hansen KB, Boedtkjer DMB, Aalkjaer C, Boron WF.

J Cereb Blood Flow Metab. 2016 May;36(5):965-80. doi: 10.1177/0271678X15610787. Epub 2015 Oct 19.

34.

The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output.

Smerup M, Damkjær M, Brøndum E, Baandrup UT, Kristiansen SB, Nygaard H, Funder J, Aalkjær C, Sauer C, Buchanan R, Bertelsen MF, Østergaard K, Grøndahl C, Candy G, Hasenkam JM, Secher NH, Bie P, Wang T.

J Exp Biol. 2016 Feb;219(Pt 3):457-63. doi: 10.1242/jeb.132753. Epub 2015 Dec 7.

35.

Extracellular Calcium-Dependent Modulation of Endothelium Relaxation in Rat Mesenteric Small Artery: The Role of Potassium Signaling.

Hangaard L, Jessen PB, Kamaev D, Aalkjaer C, Matchkov VV.

Biomed Res Int. 2015;2015:758346. doi: 10.1155/2015/758346. Epub 2015 Oct 4.

36.

Impaired endothelial calcium signaling is responsible for the defective dilation of mesenteric resistance arteries from db/db mice to acetylcholine.

Chen H, Kold-Petersen H, Laher I, Simonsen U, Aalkjaer C.

Eur J Pharmacol. 2015 Nov 15;767:17-23. doi: 10.1016/j.ejphar.2015.09.043. Epub 2015 Sep 28.

PMID:
26420355
37.

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression.

Matchkov VV, Kravtsova VV, Wiborg O, Aalkjaer C, Bouzinova EV.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R814-23. doi: 10.1152/ajpregu.00337.2014. Epub 2015 Aug 12.

38.

Prostaglandin induced changes in the tone of porcine retinal arterioles in vitro involve other factors than calcium activity in perivascular cells.

Kudryavtseva O, Aalkjær C, Bek T.

Exp Eye Res. 2015 Sep;138:96-103. doi: 10.1016/j.exer.2015.06.031. Epub 2015 Jul 2.

PMID:
26142955
39.

The giraffe kidney tolerates high arterial blood pressure by high renal interstitial pressure and low glomerular filtration rate.

Damkjaer M, Wang T, Brøndum E, Østergaard KH, Baandrup U, Hørlyck A, Hasenkam JM, Smerup M, Funder J, Marcussen N, Danielsen CC, Bertelsen MF, Grøndahl C, Pedersen M, Agger P, Candy G, Aalkjaer C, Bie P.

Acta Physiol (Oxf). 2015 Aug;214(4):497-510. doi: 10.1111/apha.12531. Epub 2015 Jun 15.

PMID:
26010805
40.

Voltage-gated sodium channels contribute to action potentials and spontaneous contractility in isolated human lymphatic vessels.

Telinius N, Majgaard J, Kim S, Katballe N, Pahle E, Nielsen J, Hjortdal V, Aalkjaer C, Boedtkjer DB.

J Physiol. 2015 Jul 15;593(14):3109-22. doi: 10.1113/JP270166.

41.

The role of Ca(2+) activated Cl(-) channels in blood pressure control.

Matchkov VV, Boedtkjer DM, Aalkjaer C.

Curr Opin Pharmacol. 2015 Apr;21:127-37. doi: 10.1016/j.coph.2015.02.003. Epub 2015 Feb 28. Review.

PMID:
25727479
42.

The bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth muscles.

Dam VS, Boedtkjer DM, Aalkjaer C, Matchkov V.

Channels (Austin). 2014;8(4):361-9. Review.

43.

Role of peripheral vascular resistance for the association between major depression and cardiovascular disease.

Bouzinova EV, Wiborg O, Aalkjaer C, Matchkov VV.

J Cardiovasc Pharmacol. 2015 Apr;65(4):299-307. doi: 10.1097/FJC.0000000000000187. Review.

44.

Cation-coupled bicarbonate transporters.

Aalkjaer C, Boedtkjer E, Choi I, Lee S.

Compr Physiol. 2014 Oct;4(4):1605-37. doi: 10.1002/cphy.c130005. Review.

45.

Dorzolamide-induced relaxation of porcine retinal arterioles in vitro depends on nitric oxide but not on acidosis in vascular smooth muscle cells.

El-Galaly A, Aalkjaer C, Kringelholt SK, Misfeldt MW, Bek T.

Exp Eye Res. 2014 Nov;128:67-72. doi: 10.1016/j.exer.2014.09.006. Epub 2014 Sep 20.

PMID:
25251883
46.

Human lymphatic vessel contractile activity is inhibited in vitro but not in vivo by the calcium channel blocker nifedipine.

Telinius N, Mohanakumar S, Majgaard J, Kim S, Pilegaard H, Pahle E, Nielsen J, de Leval M, Aalkjaer C, Hjortdal V, Boedtkjer DB.

J Physiol. 2014 Nov 1;592(21):4697-714. doi: 10.1113/jphysiol.2014.276683. Epub 2014 Aug 28.

47.

Trophic action of sympathetic nerves reduces arterial smooth muscle Ca(2+) sensitivity during early post-natal development in rats.

Puzdrova VA, Kudryashova TV, Gaynullina DK, Mochalov SV, Aalkjaer C, Nilsson H, Vorotnikov AV, Schubert R, Tarasova OS.

Acta Physiol (Oxf). 2014 Oct;212(2):128-41. doi: 10.1111/apha.12331. Epub 2014 Jul 3.

PMID:
24947441
48.

Association between endothelial dysfunction and depression-like symptoms in chronic mild stress model of depression.

Bouzinova EV, Norregaard R, Boedtkjer DM, Razgovorova IA, Moeller AM, Kudryavtseva O, Wiborg O, Aalkjaer C, Matchkov VV.

Psychosom Med. 2014 May;76(4):268-76. doi: 10.1097/PSY.0000000000000062.

PMID:
24804883
49.

The contribution of K(+) channels to human thoracic duct contractility.

Telinius N, Kim S, Pilegaard H, Pahle E, Nielsen J, Hjortdal V, Aalkjaer C, Boedtkjer DB.

Am J Physiol Heart Circ Physiol. 2014 Jul 1;307(1):H33-43.

50.

Hemodynamics and function of resistance arteries in healthy persons and end stage renal disease patients.

Borg MK, Ivarsen P, Brøndum E, Povlsen JV, Aalkjær C.

PLoS One. 2014 Apr 10;9(4):e94638. doi: 10.1371/journal.pone.0094638. eCollection 2014.

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