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See also: AAK1 AP2 associated kinase 1 in the Gene database

aak1 in Homo sapiensMus musculusRattus norvegicusAll 260 Gene records

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Items: 1 to 20 of 61

1.

Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.

Wrobel AG, Kadlecova Z, Kamenicky J, Yang JC, Herrmann T, Kelly BT, McCoy AJ, Evans PR, Martin S, Müller S, Sroubek F, Neuhaus D, Höning S, Owen DJ.

Dev Cell. 2019 Aug 19;50(4):494-508.e11. doi: 10.1016/j.devcel.2019.07.017.

2.

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S.

J Med Chem. 2019 Jun 27;62(12):5810-5831. doi: 10.1021/acs.jmedchem.9b00136. Epub 2019 Jun 12.

PMID:
31136173
3.

Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns.

Brommage R, Powell DR, Vogel P.

Dis Model Mech. 2019 May 7;12(5). pii: dmm038224. doi: 10.1242/dmm.038224. Review.

4.

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS.

Cell Chem Biol. 2019 Jun 20;26(6):818-829.e9. doi: 10.1016/j.chembiol.2019.02.021. Epub 2019 Apr 11.

PMID:
30982749
5.

Transcriptome Analysis of mRNA in Uterine Leiomyoma Using Next-Generation RNA Sequencing.

Anjum S, Sahar T, Nigam A, Wajid S.

Anticancer Agents Med Chem. 2019 Apr 8. doi: 10.2174/1871520619666190409102855. [Epub ahead of print]

PMID:
30963983
6.

Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen.

Shehata SN, Deak M, Collodet C, Spiegl SF, Geley S, Sumpton D, Sakamoto K.

Cell Signal. 2019 Jul;59:53-61. doi: 10.1016/j.cellsig.2019.03.012. Epub 2019 Mar 14.

7.

MHC Class I Internalization via Autophagy Proteins.

Loi M, Ligeon LA, Münz C.

Methods Mol Biol. 2019;1880:455-477. doi: 10.1007/978-1-4939-8873-0_29.

PMID:
30610715
8.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB.

Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023.

9.

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy.

Leonardi M, Perna E, Tronnolone S, Colecchia D, Chiariello M.

Autophagy. 2019 Feb;15(2):312-326. doi: 10.1080/15548627.2018.1517855. Epub 2018 Oct 5.

10.

Ndr kinases regulate retinal interneuron proliferation and homeostasis.

Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC.

Sci Rep. 2018 Aug 22;8(1):12544. doi: 10.1038/s41598-018-30492-9.

11.

Periodic Variation of AAK1 in an Aβ1-42-Induced Mouse Model of Alzheimer's Disease.

Fu X, Ke M, Yu W, Wang X, Xiao Q, Gu M, Lü Y.

J Mol Neurosci. 2018 Jun;65(2):179-189. doi: 10.1007/s12031-018-1085-3. Epub 2018 May 17.

PMID:
29774516
12.

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment.

Pu SY, Xiao F, Schor S, Bekerman E, Zanini F, Barouch-Bentov R, Nagamine CM, Einav S.

Antiviral Res. 2018 Jul;155:67-75. doi: 10.1016/j.antiviral.2018.05.001. Epub 2018 May 16.

13.

Novel Pharmacological Nonopioid Therapies in Chronic Pain.

Kaye AD, Cornett EM, Hart B, Patil S, Pham A, Spalitta M, Mancuso KF.

Curr Pain Headache Rep. 2018 Apr 3;22(4):31. doi: 10.1007/s11916-018-0674-8. Review.

PMID:
29616344
14.

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.

Xiao F, Wang S, Barouch-Bentov R, Neveu G, Pu S, Beer M, Schor S, Kumar S, Nicolaescu V, Lindenbach BD, Randall G, Einav S.

MBio. 2018 Mar 13;9(2). pii: e02233-17. doi: 10.1128/mBio.02233-17.

15.

Inhibitors of Adaptor-Associated Kinase 1 (AAK1) May Treat Neuropathic Pain, Schizophrenia, Parkinson's Disease, and Other Disorders.

Abdel-Magid AF.

ACS Med Chem Lett. 2017 May 26;8(6):595-597. doi: 10.1021/acsmedchemlett.7b00208. eCollection 2017 Jun 8. No abstract available.

16.

[3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement.

Louis JV, Lu Y, Pieschl R, Tian Y, Hong Y, Dandapani K, Naidu S, Vikramadithyan RK, Dzierba C, Sarvasiddhi SK, Nara SJ, Bronson J, Macor JE, Albright C, Kostich W, Li YW.

Neuropharmacology. 2017 May 15;118:167-174. doi: 10.1016/j.neuropharm.2017.03.015. Epub 2017 Mar 15.

PMID:
28315351
17.

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.

Bekerman E, Neveu G, Shulla A, Brannan J, Pu SY, Wang S, Xiao F, Barouch-Bentov R, Bakken RR, Mateo R, Govero J, Nagamine CM, Diamond MS, De Jonghe S, Herdewijn P, Dye JM, Randall G, Einav S.

J Clin Invest. 2017 Apr 3;127(4):1338-1352. doi: 10.1172/JCI89857. Epub 2017 Feb 27.

18.

Lineage-specific proteins essential for endocytosis in trypanosomes.

Manna PT, Obado SO, Boehm C, Gadelha C, Sali A, Chait BT, Rout MP, Field MC.

J Cell Sci. 2017 Apr 15;130(8):1379-1392. doi: 10.1242/jcs.191478. Epub 2017 Feb 23.

19.

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.

Kadlecova Z, Spielman SJ, Loerke D, Mohanakrishnan A, Reed DK, Schmid SL.

J Cell Biol. 2017 Jan 2;216(1):167-179. doi: 10.1083/jcb.201608071. Epub 2016 Dec 21.

20.

Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma.

Jang JS, Wang X, Vedell PT, Wen J, Zhang J, Ellison DW, Evans JM, Johnson SH, Yang P, Sukov WR, Oliveira AM, Vasmatzis G, Sun Z, Jen J, Yi ES.

J Thorac Oncol. 2016 Nov;11(11):1891-1900. doi: 10.1016/j.jtho.2016.06.001. Epub 2016 Jun 22.

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