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Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy.

Askou AL, Alsing S, Benckendorff JNE, Holmgaard A, Mikkelsen JG, Aagaard L, Bek T, Corydon TJ.

Mol Ther Nucleic Acids. 2019 Jun 7;16:38-50. doi: 10.1016/j.omtn.2019.01.012. Epub 2019 Feb 2.


Efficient Knockdown and Lack of Passenger Strand Activity by Dicer-Independent shRNAs Expressed from Pol II-Driven MicroRNA Scaffolds.

Kaadt E, Alsing S, Cecchi CR, Damgaard CK, Corydon TJ, Aagaard L.

Mol Ther Nucleic Acids. 2019 Mar 1;14:318-328. doi: 10.1016/j.omtn.2018.11.013. Epub 2018 Dec 1.


Off-Label Prescribing of Antipsychotics in a Danish Child and Adolescent Mental Health Center: A Register-Based Study.

Kornø KT, Aagaard L.

J Res Pharm Pract. 2018 Oct-Dec;7(4):205-209. doi: 10.4103/jrpp.JRPP_18_42.


Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs.

Hollensen AK, Andersen S, Hjorth K, Bak RO, Hansen TB, Kjems J, Aagaard L, Damgaard CK, Mikkelsen JG.

Mol Ther Nucleic Acids. 2018 Dec 7;13:365-375. doi: 10.1016/j.omtn.2018.09.009. Epub 2018 Sep 21.


Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein.

Dalsgaard T, Cecchi CR, Askou AL, Bak RO, Andersen PO, Hougaard D, Jensen TG, Dagnæs-Hansen F, Mikkelsen JG, Corydon TJ, Aagaard L.

Mol Ther Nucleic Acids. 2018 Sep 7;12:672-683. doi: 10.1016/j.omtn.2018.07.005. Epub 2018 Aug 6.


Effect of a medicines management model on medication-related readmissions in older patients admitted to a medical acute admission unit-A randomized controlled trial.

Graabaek T, Hedegaard U, Christensen MB, Clemmensen MH, Knudsen T, Aagaard L.

J Eval Clin Pract. 2019 Feb;25(1):88-96. doi: 10.1111/jep.13013. Epub 2018 Aug 7.


Screening, Brief Intervention, and Referral to Treatment: Nurses Helping Colorado Training Program.

Cook PF, Aagaard L, Bowler F, Rosenthal L, Avery LK, Weber M.

J Nurs Educ. 2018 Aug 1;57(8):476-482. doi: 10.3928/01484834-20180720-05.


Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies.

Storebø OJ, Pedersen N, Ramstad E, Kielsholm ML, Nielsen SS, Krogh HB, Moreira-Maia CR, Magnusson FL, Holmskov M, Gerner T, Skoog M, Rosendal S, Groth C, Gillies D, Buch Rasmussen K, Gauci D, Zwi M, Kirubakaran R, Håkonsen SJ, Aagaard L, Simonsen E, Gluud C.

Cochrane Database Syst Rev. 2018 May 9;5:CD012069. doi: 10.1002/14651858.CD012069.pub2. Review.


Off-label and unlicensed prescribing in Europe: implications for patients' informed consent and liability.

Aagaard L, Kristensen K.

Int J Clin Pharm. 2018 Jun;40(3):509-512. doi: 10.1007/s11096-018-0646-4.


The role of miR-29a in HIV-1 replication and latency.

Frattari G, Aagaard L, Denton PW.

J Virus Erad. 2017 Oct 1;3(4):185-191.


A multi-national comparison of antipsychotic drug use in children and adolescents, 2005-2012.

Kalverdijk LJ, Bachmann CJ, Aagaard L, Burcu M, Glaeske G, Hoffmann F, Petersen I, Schuiling-Veninga CCM, Wijlaars LP, Zito JM.

Child Adolesc Psychiatry Ment Health. 2017 Oct 11;11:55. doi: 10.1186/s13034-017-0192-1. eCollection 2017.


Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs.

Askou AL, Benckendorff JNE, Holmgaard A, Storm T, Aagaard L, Bek T, Mikkelsen JG, Corydon TJ.

Hum Gene Ther Methods. 2017 Aug;28(4):222-233. doi: 10.1089/hgtb.2017.079.


International trends in antipsychotic use: A study in 16 countries, 2005-2014.

Hálfdánarson Ó, Zoëga H, Aagaard L, Bernardo M, Brandt L, Fusté AC, Furu K, Garuoliené K, Hoffmann F, Huybrechts KF, Kalverdijk LJ, Kawakami K, Kieler H, Kinoshita T, Litchfield M, López SC, Machado-Alba JE, Machado-Duque ME, Mahesri M, Nishtala PS, Pearson SA, Reutfors J, Saastamoinen LK, Sato I, Schuiling-Veninga CCM, Shyu YC, Skurtveit S, Verdoux H, Wang LJ, Yahni CZ, Bachmann CJ.

Eur Neuropsychopharmacol. 2017 Oct;27(10):1064-1076. doi: 10.1016/j.euroneuro.2017.07.001. Epub 2017 Jul 27.


Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs.

Askou AL, Benckendorff JNE, Holmgaard A, Storm T, Aagaard L, Bek T, Mikkelsen JG, Corydon TJ.

Hum Gene Ther Methods. 2017 Jul 27. doi: 10.1089/hum.2017.079. [Epub ahead of print]


Long-term patterns of adherence to medication therapy among patients with type 2 diabetes mellitus in Denmark: The importance of initiation.

Jensen ML, Jørgensen ME, Hansen EH, Aagaard L, Carstensen B.

PLoS One. 2017 Jun 30;12(6):e0179546. doi: 10.1371/journal.pone.0179546. eCollection 2017.


Specific Genes Associated with Adverse Events of Methylphenidate Use in the Pediatric Population: A Systematic Literature Review.

Joensen B, Meyer M, Aagaard L.

J Res Pharm Pract. 2017 Apr-Jun;6(2):65-72. doi: 10.4103/jrpp.JRPP_16_161. Review.


International trends in clozapine use: a study in 17 countries.

Bachmann CJ, Aagaard L, Bernardo M, Brandt L, Cartabia M, Clavenna A, Coma Fusté A, Furu K, Garuoliené K, Hoffmann F, Hollingworth S, Huybrechts KF, Kalverdijk LJ, Kawakami K, Kieler H, Kinoshita T, López SC, Machado-Alba JE, Machado-Duque ME, Mahesri M, Nishtala PS, Piovani D, Reutfors J, Saastamoinen LK, Sato I, Schuiling-Veninga CCM, Shyu YC, Siskind D, Skurtveit S, Verdoux H, Wang LJ, Zara Yahni C, Zoëga H, Taylor D.

Acta Psychiatr Scand. 2017 Jul;136(1):37-51. doi: 10.1111/acps.12742. Epub 2017 May 14.


Improved microRNA suppression by WPRE-linked tough decoy microRNA sponges.

Hollensen AK, Thomsen R, Bak RO, Petersen CC, Ermegaard ER, Aagaard L, Damgaard CK, Mikkelsen JG.

RNA. 2017 Aug;23(8):1247-1258. doi: 10.1261/rna.061192.117. Epub 2017 May 9.


Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene.

Toustrup LB, Zhou Y, Kvistgaard H, Gregersen N, Rittig S, Aagaard L, Corydon TJ, Luo Y, Christensen JH.

Stem Cell Res. 2017 Mar;19:37-42. doi: 10.1016/j.scr.2016.12.021. Epub 2016 Dec 24.


Trends in ADHD medication use in children and adolescents in five western countries, 2005-2012.

Bachmann CJ, Wijlaars LP, Kalverdijk LJ, Burcu M, Glaeske G, Schuiling-Veninga CCM, Hoffmann F, Aagaard L, Zito JM.

Eur Neuropsychopharmacol. 2017 May;27(5):484-493. doi: 10.1016/j.euroneuro.2017.03.002. Epub 2017 Mar 20.


Dipeptidyl Peptidase-4 Inhibitor Induced Angioedema - An Overlooked Adverse Drug Reaction?

Scott SI, Andersen MF, Aagaard L, Buchwald CV, Rasmussen ER.

Curr Diabetes Rev. 2018;14(4):327-333. doi: 10.2174/1573399813666170214113856. Review.


Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency.

Zhou Y, Al-Saaidi RA, Fernandez-Guerra P, Freude KK, Olsen RK, Jensen UB, Gregersen N, Hyttel P, Bolund L, Aagaard L, Bross P, Luo Y.

Stem Cells Dev. 2017 Feb 1;26(3):166-176. doi: 10.1089/scd.2016.0162. Epub 2016 Nov 28.


Serious adverse events reported for antiobesity medicines: postmarketing experiences from the EU adverse event reporting system EudraVigilance.

Aagaard L, Hallgreen CE, Hansen EH.

Int J Obes (Lond). 2016 Nov;40(11):1742-1747. doi: 10.1038/ijo.2016.135. Epub 2016 Aug 1.


Results From 10 Years of Interprofessional Training on Motivational Interviewing.

Cook PF, Manzouri S, Aagaard L, O'Connell L, Corwin M, Gance-Cleveland B.

Eval Health Prof. 2017 Jun;40(2):159-179. doi: 10.1177/0163278716656229. Epub 2016 Jun 29.


Pain monitoring and medication assessment in elderly nursing home residents with dementia.

Tang MM, Wollsen MG, Aagaard L.

J Res Pharm Pract. 2016 Apr-Jun;5(2):126-31. doi: 10.4103/2279-042X.179578.


Cutaneous Porphyrias: Causes, Symptoms, Treatments and the Danish Incidence 1989-2013.

Christiansen AL, Aagaard L, Krag A, Rasmussen LM, Bygum A.

Acta Derm Venereol. 2016 Nov 2;96(7):868-872. doi: 10.2340/00015555-2444.


Real-life experience with long-term prophylactic C1 inhibitor concentrate treatment of patients with hereditary angioedema: Effectiveness and cost.

Rasmussen ER, Aagaard L, Bygum A.

Ann Allergy Asthma Immunol. 2016 May;116(5):476-7. doi: 10.1016/j.anai.2016.03.008. Epub 2016 Mar 24. No abstract available.


Trends and patterns of antidepressant use in children and adolescents from five western countries, 2005-2012.

Bachmann CJ, Aagaard L, Burcu M, Glaeske G, Kalverdijk LJ, Petersen I, Schuiling-Veninga CC, Wijlaars L, Zito JM, Hoffmann F.

Eur Neuropsychopharmacol. 2016 Mar;26(3):411-9. doi: 10.1016/j.euroneuro.2016.02.001. Epub 2016 Feb 8.


Switch in Therapy from Methylphenidate to Atomoxetine in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: An Analysis of Patient Records.

Warrer P, Thomsen PH, Dalsgaard S, Hansen EH, Aagaard L, Wallach Kildemoes H, Rasmussen HB.

J Child Adolesc Psychopharmacol. 2016 May;26(4):354-61. doi: 10.1089/cap.2015.0060. Epub 2016 Feb 18.


Partial correction of the dwarf phenotype by non-viral transfer of the growth hormone gene in mice: Treatment age is critical.

Higuti E, Cecchi CR, Oliveira NA, Lima ER, Vieira DP, Aagaard L, Jensen TG, Jorge AA, Bartolini P, Peroni CN.

Growth Horm IGF Res. 2016 Feb;26:1-7. doi: 10.1016/j.ghir.2015.12.001. Epub 2015 Dec 2.


Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system.

Zhou Y, Liu Y, Hussmann D, Brøgger P, Al-Saaidi RA, Tan S, Lin L, Petersen TS, Zhou GQ, Bross P, Aagaard L, Klein T, Rønn SG, Pedersen HD, Bolund L, Nielsen AL, Sørensen CB, Luo Y.

Cell Mol Life Sci. 2016 Jul;73(13):2543-63. doi: 10.1007/s00018-015-2128-3. Epub 2016 Jan 11.


Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.

Kang R, Zhou Y, Tan S, Zhou G, Aagaard L, Xie L, Bünger C, Bolund L, Luo Y.

Stem Cell Res Ther. 2015 Aug 18;6:144. doi: 10.1186/s13287-015-0137-7.


Medication histories by pharmacy technicians and physicians in an emergency department.

Henriksen JP, Noerregaard S, Buck TC, Aagaard L.

Int J Clin Pharm. 2015 Dec;37(6):1121-7. doi: 10.1007/s11096-015-0172-6. Epub 2015 Aug 5.


Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin.

Jakobsen M, Askou AL, Stenderup K, Rosada C, Dagnæs-Hansen F, Jensen TG, Corydon TJ, Mikkelsen JG, Aagaard L.

Hum Gene Ther Methods. 2015 Aug;26(4):123-33. doi: 10.1089/hgtb.2014.135.


Off-Label and Unlicensed Prescribing of Medicines in Paediatric Populations: Occurrence and Safety Aspects.

Aagaard L.

Basic Clin Pharmacol Toxicol. 2015 Oct;117(4):215-8. doi: 10.1111/bcpt.12445. Epub 2015 Aug 2. No abstract available.


Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors.

Askou AL, Aagaard L, Kostic C, Arsenijevic Y, Hollensen AK, Bek T, Jensen TG, Mikkelsen JG, Corydon TJ.

Mol Ther Methods Clin Dev. 2015 Jan 28;2:14064. doi: 10.1038/mtm.2014.64. eCollection 2015.


Identification of possible adverse drug reactions in clinical notes: The case of glucose-lowering medicines.

Warrer P, Jensen PB, Aagaard L, Jensen LJ, Brunak S, Krag MH, Rossing P, Almdal T, Andersen HU, Hansen EH.

J Res Pharm Pract. 2015 Apr-Jun;4(2):64-72. doi: 10.4103/2279-042X.155753.


Molecular mechanisms in DM1 - a focus on foci.

Pettersson OJ, Aagaard L, Jensen TG, Damgaard CK.

Nucleic Acids Res. 2015 Feb 27;43(4):2433-41. doi: 10.1093/nar/gkv029. Epub 2015 Jan 20. Review.


SearCh for humourIstic and Extravagant acroNyms and Thoroughly Inappropriate names For Important Clinical trials (SCIENTIFIC): qualitative and quantitative systematic study.

Pottegård A, Haastrup MB, Stage TB, Hansen MR, Larsen KS, Meegaard PM, Meegaard LH, Horneberg H, Gils C, Dideriksen D, Aagaard L, Almarsdottir AB, Hallas J, Damkier P.

BMJ. 2014 Dec 16;349:g7092. doi: 10.1136/bmj.g7092. Review.


Discrepancies in listed adverse drug reactions in pharmaceutical product information supplied by the regulatory authorities in Denmark and the USA.

Eriksson R, Aagaard L, Jensen LJ, Borisova L, Hørlück D, Brunak S, Hansen EH.

Pharmacol Res Perspect. 2014 Jun;2(3):e00038. doi: 10.1002/prp2.38. Epub 2014 Apr 22.


Paediatric adverse drug reactions following use of asthma medications in Europe from 2007 to 2011.

Aagaard L, Hansen EH.

Int J Clin Pharm. 2014 Dec;36(6):1222-9. doi: 10.1007/s11096-014-0020-0. Epub 2014 Oct 7.


Comparison of pregnancy and lactation labeling for attention-deficit hyperactivity disorder drugs marketed in Australia, the USA, Denmark, and the UK.

Warrer P, Aagaard L, Hansen EH.

Drug Saf. 2014 Oct;37(10):805-13. doi: 10.1007/s40264-014-0215-2.


Medication reconciliation and prescribing reviews by pharmacy technicians in a geriatric ward.

Buck TC, Gronkjaer LS, Duckert ML, Rosholm JU, Aagaard L.

J Res Pharm Pract. 2013 Oct;2(4):145-50. doi: 10.4103/2279-042X.128143.


DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1.

Pettersson OJ, Aagaard L, Andrejeva D, Thomsen R, Jensen TG, Damgaard CK.

Nucleic Acids Res. 2014 Jun;42(11):7186-200. doi: 10.1093/nar/gku352. Epub 2014 May 3.


Chemical castration of Danish sex offenders.

Aagaard L.

J Bioeth Inq. 2014 Jun;11(2):117-8. doi: 10.1007/s11673-014-9534-3. Epub 2014 May 2. No abstract available.


A multistate model and an algorithm for measuring long-term adherence to medication: a case of diabetes mellitus type 2.

Jensen ML, Jørgensen ME, Hansen EH, Aagaard L, Carstensen B.

Value Health. 2014 Mar;17(2):266-74. doi: 10.1016/j.jval.2013.11.014.


Adverse drug reactions associated with asthma medications in children: systematic review of clinical trials.

Aagaard L, Hansen EH.

Int J Clin Pharm. 2014 Apr;36(2):243-52. doi: 10.1007/s11096-014-9924-y. Epub 2014 Feb 23. Review.


A novel homologous model for gene therapy of dwarfism by non-viral transfer of the mouse growth hormone gene into immunocompetent dwarf mice.

Cecchi CR, Higuti E, Oliveira NA, Lima ER, Jakobsen M, Dagnaes-Hansen F, Gissel H, Aagaard L, Jensen TG, Jorge AA, Bartolini P, Peroni CN.

Curr Gene Ther. 2014 Feb;14(1):44-51.


First-trimester exposure to methylphenidate: a population-based cohort study.

Pottegård A, Hallas J, Andersen JT, Løkkegaard EC, Dideriksen D, Aagaard L, Damkier P.

J Clin Psychiatry. 2014 Jan;75(1):e88-93. doi: 10.4088/JCP.13m08708.


Adverse drug reactions in children reported by European consumers from 2007 to 2011.

Aagaard L, Hansen EH.

Int J Clin Pharm. 2014 Apr;36(2):295-302. doi: 10.1007/s11096-013-9874-9. Epub 2013 Nov 5.


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