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Items: 47


Targeting the Mincle and TLR3 receptor using the dual agonist cationic adjuvant formulation 9 (CAF09) induces humoral and polyfunctional memory T cell responses in calves.

Thakur A, Andrea A, Mikkelsen H, Woodworth JS, Andersen P, Jungersen G, Aagaard C.

PLoS One. 2018 Jul 31;13(7):e0201253. doi: 10.1371/journal.pone.0201253. eCollection 2018.


Cross reactive immune responses in cattle arising from exposure to Mycobacterium bovis and non-tuberculous mycobacteria.

Jenkins AO, Gormley E, Gcebe N, Fosgate GT, Conan A, Aagaard C, Michel AL, Rutten VPMG.

Prev Vet Med. 2018 Apr 1;152:16-22. doi: 10.1016/j.prevetmed.2018.02.003. Epub 2018 Feb 9.


Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis.

Jensen C, Lindebo Holm L, Svensson E, Aagaard C, Ruhwald M.

Sci Rep. 2017 Jun 6;7(1):2830. doi: 10.1038/s41598-017-02116-1.


An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology.

Clemmensen HS, Knudsen NPH, Rasmussen EM, Winkler J, Rosenkrands I, Ahmad A, Lillebaek T, Sherman DR, Andersen PL, Aagaard C.

Sci Rep. 2017 Apr 24;7:46666. doi: 10.1038/srep46666.


High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection.

Lindenstrøm T, Aagaard C, Christensen D, Agger EM, Andersen P.

Eur J Immunol. 2014 Jun;44(6):1699-709. doi: 10.1002/eji.201344358. Epub 2014 Mar 27.


Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation.

Woodworth JS, Aagaard CS, Hansen PR, Cassidy JP, Agger EM, Andersen P.

J Immunol. 2014 Apr 1;192(7):3247-58. doi: 10.4049/jimmunol.1300283. Epub 2014 Feb 26.


Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.

Knudsen NP, Nørskov-Lauritsen S, Dolganov GM, Schoolnik GK, Lindenstrøm T, Andersen P, Agger EM, Aagaard C.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1096-101. doi: 10.1073/pnas.1314973111. Epub 2014 Jan 6.


ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination.

Hoang T, Aagaard C, Dietrich J, Cassidy JP, Dolganov G, Schoolnik GK, Lundberg CV, Agger EM, Andersen P.

PLoS One. 2013 Dec 12;8(12):e80579. doi: 10.1371/journal.pone.0080579. eCollection 2013.


Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model.

Billeskov R, Christensen JP, Aagaard C, Andersen P, Dietrich J.

PLoS One. 2013 Aug 19;8(8):e72185. doi: 10.1371/journal.pone.0072185. eCollection 2013.


Broadening of the T-cell repertoire to HIV-1 Gag p24 by vaccination of HLA-A2/DR transgenic mice with overlapping peptides in the CAF05 adjuvant.

Korsholm KS, Karlsson I, Tang ST, Brandt L, Agger EM, Aagaard C, Andersen P, Fomsgaard A.

PLoS One. 2013 May 17;8(5):e63575. doi: 10.1371/journal.pone.0063575. Print 2013.


Cell-mediated and humoral immune responses after immunization of calves with a recombinant multiantigenic Mycobacterium avium subsp. paratuberculosis subunit vaccine at different ages.

Thakur A, Aagaard C, Stockmarr A, Andersen P, Jungersen G.

Clin Vaccine Immunol. 2013 Apr;20(4):551-8. doi: 10.1128/CVI.05574-11. Epub 2013 Feb 6.


Vaccine-induced th17 cells are maintained long-term postvaccination as a distinct and phenotypically stable memory subset.

Lindenstrøm T, Woodworth J, Dietrich J, Aagaard C, Andersen P, Agger EM.

Infect Immun. 2012 Oct;80(10):3533-44. doi: 10.1128/IAI.00550-12. Epub 2012 Jul 30.


Correlation of antigen-specific IFN-γ responses of fresh blood samples from Mycobacterium avium subsp. paratuberculosis infected heifers with responses of day-old samples co-cultured with IL-12 or anti-IL-10 antibodies.

Mikkelsen H, Aagaard C, Nielsen SS, Jungersen G.

Vet Immunol Immunopathol. 2012 Jun 15;147(1-2):69-76. doi: 10.1016/j.vetimm.2012.04.002. Epub 2012 Apr 17.


CAF05: cationic liposomes that incorporate synthetic cord factor and poly(I:C) induce CTL immunity and reduce tumor burden in mice.

Hansen J, Lindenstrøm T, Lindberg-Levin J, Aagaard C, Andersen P, Agger EM.

Cancer Immunol Immunother. 2012 Jun;61(6):893-903. doi: 10.1007/s00262-011-1156-6. Epub 2011 Nov 18.


Novel antigens for detection of cell mediated immune responses to Mycobacterium avium subsp. paratuberculosis infection in cattle.

Mikkelsen H, Aagaard C, Nielsen SS, Jungersen G.

Vet Immunol Immunopathol. 2011 Sep 15;143(1-2):46-54. doi: 10.1016/j.vetimm.2011.06.022. Epub 2011 Jun 13. Erratum in: Vet Immunol Immunopathol. 2012 May 15;146(3-4):296-8.


A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis.

McCallan L, Corbett D, Andersen PL, Aagaard C, McMurray D, Barry C, Thompson S, Strain S, McNair J.

Vet Med Int. 2011 Apr 12;2011:981410. doi: 10.4061/2011/981410.


Review of Mycobacterium avium subsp. paratuberculosis antigen candidates with diagnostic potential.

Mikkelsen H, Aagaard C, Nielsen SS, Jungersen G.

Vet Microbiol. 2011 Aug 26;152(1-2):1-20. doi: 10.1016/j.vetmic.2011.03.006. Epub 2011 Mar 16. Review.


A multistage tuberculosis vaccine that confers efficient protection before and after exposure.

Aagaard C, Hoang T, Dietrich J, Cardona PJ, Izzo A, Dolganov G, Schoolnik GK, Cassidy JP, Billeskov R, Andersen P.

Nat Med. 2011 Feb;17(2):189-94. doi: 10.1038/nm.2285. Epub 2011 Jan 23.


Detection of bovine tuberculosis in herds with different disease prevalence and influence of paratuberculosis infection on PPDB and ESAT-6/CFP10 specificity.

Aagaard C, Govaerts M, Meikle V, Gutiérrez-Pabello JA, McNair J, Andersen P, Suárez-Güemes F, Pollock J, Espitia C, Cataldi A.

Prev Vet Med. 2010 Sep 1;96(3-4):161-9. doi: 10.1016/j.prevetmed.2010.06.007. Epub 2010 Jul 14.


Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis.

Billeskov R, Grandal MV, Poulsen C, Christensen JP, Winther N, Vingsbo-Lundberg C, Hoang TT, van Deurs B, Song YH, Aagaard C, Andersen P, Dietrich J.

Eur J Immunol. 2010 May;40(5):1342-54. doi: 10.1002/eji.200939830. Erratum in: Eur J Immunol. 2011 Mar;41(3):873.


Quality and vaccine efficacy of CD4+ T cell responses directed to dominant and subdominant epitopes in ESAT-6 from Mycobacterium tuberculosis.

Aagaard CS, Hoang TT, Vingsbo-Lundberg C, Dietrich J, Andersen P.

J Immunol. 2009 Aug 15;183(4):2659-68. doi: 10.4049/jimmunol.0900947. Epub 2009 Jul 20.


Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose.

Aagaard C, Hoang TT, Izzo A, Billeskov R, Troudt J, Arnett K, Keyser A, Elvang T, Andersen P, Dietrich J.

PLoS One. 2009 Jun 16;4(6):e5930. doi: 10.1371/journal.pone.0005930.


Distinct differences in the expansion and phenotype of TB10.4 specific CD8 and CD4 T cells after infection with Mycobacterium tuberculosis.

Hoang TT, Nansen A, Roy S, Billeskov R, Aagaard C, Elvang T, Dietrich J, Andersen P.

PLoS One. 2009 Jun 16;4(6):e5928. doi: 10.1371/journal.pone.0005928.


Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells.

Lindenstrøm T, Agger EM, Korsholm KS, Darrah PA, Aagaard C, Seder RA, Rosenkrands I, Andersen P.

J Immunol. 2009 Jun 15;182(12):8047-55. doi: 10.4049/jimmunol.0801592.


Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.

Olsen I, Tollefsen S, Aagaard C, Reitan LJ, Bannantine JP, Andersen P, Sollid LM, Lundin KE.

PLoS One. 2009 May 22;4(5):e5641. doi: 10.1371/journal.pone.0005641.


TB vaccines: current status and future perspectives.

Aagaard C, Dietrich J, Doherty M, Andersen P.

Immunol Cell Biol. 2009 May-Jun;87(4):279-86. doi: 10.1038/icb.2009.14. Epub 2009 Apr 7. Review.


Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements.

Agger EM, Rosenkrands I, Hansen J, Brahimi K, Vandahl BS, Aagaard C, Werninghaus K, Kirschning C, Lang R, Christensen D, Theisen M, Follmann F, Andersen P.

PLoS One. 2008 Sep 8;3(9):e3116. doi: 10.1371/journal.pone.0003116.


Identification of Rv0222 from RD4 as a novel serodiagnostic target for tuberculosis.

Rosenkrands I, Aagaard C, Weldingh K, Brock I, Dziegiel MH, Singh M, Hoff S, Ravn P, Andersen P.

Tuberculosis (Edinb). 2008 Jul;88(4):335-43. doi: 10.1016/ Epub 2008 Feb 19.


Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis.

Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M.

J Mol Biol. 2008 Feb 15;376(2):554-69. doi: 10.1016/j.jmb.2007.11.099. Epub 2007 Dec 5.


Optimizing antigen cocktails for detection of Mycobacterium bovis in herds with different prevalences of bovine tuberculosis: ESAT6-CFP10 mixture shows optimal sensitivity and specificity.

Aagaard C, Govaerts M, Meikle V, Vallecillo AJ, Gutierrez-Pabello JA, Suarez-Güemes F, McNair J, Cataldi A, Espitia C, Andersen P, Pollock JM.

J Clin Microbiol. 2006 Dec;44(12):4326-35. Epub 2006 Sep 27.


Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.

Langermans JA, Doherty TM, Vervenne RA, van der Laan T, Lyashchenko K, Greenwald R, Agger EM, Aagaard C, Weiler H, van Soolingen D, Dalemans W, Thomas AW, Andersen P.

Vaccine. 2005 Apr 15;23(21):2740-50.


Mapping immune reactivity toward Rv2653 and Rv2654: two novel low-molecular-mass antigens found specifically in the Mycobacterium tuberculosis complex.

Aagaard C, Brock I, Olsen A, Ottenhoff TH, Weldingh K, Andersen P.

J Infect Dis. 2004 Mar 1;189(5):812-9. Epub 2004 Feb 13.


Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis.

Agger EM, Brock I, Okkels LM, Arend SM, Aagaard CS, Weldingh KN, Andersen P.

Immunology. 2003 Dec;110(4):507-12.


Genomic approach to identification of Mycobacterium bovis diagnostic antigens in cattle.

Aagaard C, Govaerts M, Meng Okkels L, Andersen P, Pollock JM.

J Clin Microbiol. 2003 Aug;41(8):3719-28.


Improved serodetection of Mycobacterium bovis infection in badgers (Meles meles) using multiantigen test formats.

Greenwald R, Esfandiari J, Lesellier S, Houghton R, Pollock J, Aagaard C, Andersen P, Hewinson RG, Chambers M, Lyashchenko K.

Diagn Microbiol Infect Dis. 2003 Jul;46(3):197-203.


Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins.

Rosenkrands I, Slayden RA, Crawford J, Aagaard C, Barry CE 3rd, Andersen P.

J Bacteriol. 2002 Jul;184(13):3485-91.


Self-assembly of recombinant prion protein of 106 residues.

Baskakov IV, Aagaard C, Mehlhorn I, Wille H, Groth D, Baldwin MA, Prusiner SB, Cohen FE.

Biochemistry. 2000 Mar 14;39(10):2792-804.


Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice.

Supattapone S, Bosque P, Muramoto T, Wille H, Aagaard C, Peretz D, Nguyen HO, Heinrich C, Torchia M, Safar J, Cohen FE, DeArmond SJ, Prusiner SB, Scott M.

Cell. 1999 Mar 19;96(6):869-78.


Archaeal introns: splicing, intercellular mobility and evolution.

Lykke-Andersen J, Aagaard C, Semionenkov M, Garrett RA.

Trends Biochem Sci. 1997 Sep;22(9):326-31. Review.


Profile of the DNA recognition site of the archaeal homing endonuclease I-DmoI.

Aagaard C, Awayez MJ, Garrett RA.

Nucleic Acids Res. 1997 Apr 15;25(8):1523-30.


General vectors for archaeal hyperthermophiles: strategies based on a mobile intron and a plasmid.

Aagaard C, Leviev I, Aravalli RN, Forterre P, Prieur D, Garrett RA.

FEMS Microbiol Rev. 1996 May;18(2-3):93-104. Review.


Requirement for a conserved, tertiary interaction in the core of 23S ribosomal RNA.

Aagaard C, Douthwaite S.

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2989-93.


Specific structural probing of plasmid-coded ribosomal RNAs from Escherichia coli.

Aagaard C, Rosendahl G, Dam M, Powers T, Douthwaite S.

Biochimie. 1991 Dec;73(12):1439-44.


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