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Can earlier BCG vaccination reduce early infant mortality? Study protocol for a cluster randomised trial in Guinea-Bissau.

Thysen SM, Jensen AKG, Rodrigues A, Borges IDS, Aaby P, Benn C, Fisker A.

BMJ Open. 2019 Sep 24;9(9):e025724. doi: 10.1136/bmjopen-2018-025724.


Smallpox and BCG vaccination in childhood and cutaneous malignant melanoma in Danish adults followed from 18 to 49 years.

Rieckmann A, Meyle KD, Rod NH, Baker JL, Benn CS, Aaby P, Sørup S.

Vaccine. 2019 Oct 16;37(44):6730-6736. doi: 10.1016/j.vaccine.2019.09.023. Epub 2019 Sep 16.


Out-of-sequence DTP and measles vaccinations and child mortality in Guinea-Bissau: a reanalysis.

Thysen SM, Rodrigues A, Aaby P, Fisker AB.

BMJ Open. 2019 Sep 5;9(9):e024893. doi: 10.1136/bmjopen-2018-024893.


Developing the concept of beneficial non-specific effect of live vaccines with epidemiological studies.

Aaby P, Benn CS.

Clin Microbiol Infect. 2019 Aug 23. pii: S1198-743X(19)30452-5. doi: 10.1016/j.cmi.2019.08.011. [Epub ahead of print] Review.


The Guinea-Bissau Twin Registry Update: A Platform for Studying Twin Mortality and Metabolic Disease.

Bjerregaard-Andersen M, Gomes GM, Hennild DE, Jensen DM, Christensen K, Sodemann M, Beck-Nielsen H, Aaby P.

Twin Res Hum Genet. 2019 Jul 18:1-7. doi: 10.1017/thg.2019.39. [Epub ahead of print]


Cohort profile : Bandim Health Project's (BHP) rural Health and Demographic Surveillance System (HDSS)-a nationally representative HDSS in Guinea-Bissau.

Thysen SM, Fernandes M, Benn CS, Aaby P, Fisker AB.

BMJ Open. 2019 Jun 11;9(6):e028775. doi: 10.1136/bmjopen-2018-028775.


Measles, mumps and rubella vs diphtheria-tetanus-acellular-pertussis-inactivated-polio-Haemophilus influenzae type b as the most recent vaccine and risk of early 'childhood asthma'.

Rieckmann A, Hærskjold A, Benn CS, Aaby P, Lange T, Sørup S.

Int J Epidemiol. 2019 Apr 10. pii: dyz062. doi: 10.1093/ije/dyz062. [Epub ahead of print]



Blok BA, de Bree LCJ, Diavatopoulos DA, Langereis JD, Joosten LAB, Aaby P, van Crevel R, Benn CS, Netea MG.

Clin Infect Dis. 2019 Mar 28. pii: ciz246. doi: 10.1093/cid/ciz246. [Epub ahead of print]


Lessons Learned from the Testing of Neonatal Vitamin A Supplementation.

Benn CS, Aaby P, Fisker AB.

Nutrients. 2019 Feb 21;11(2). pii: E449. doi: 10.3390/nu11020449. Review.


Outcomes of controlled human malaria infection after BCG vaccination.

Walk J, de Bree LCJ, Graumans W, Stoter R, van Gemert GJ, van de Vegte-Bolmer M, Teelen K, Hermsen CC, Arts RJW, Behet MC, Keramati F, Moorlag SJCFM, Yang ASP, van Crevel R, Aaby P, de Mast Q, van der Ven AJAM, Stabell Benn C, Netea MG, Sauerwein RW.

Nat Commun. 2019 Feb 20;10(1):874. doi: 10.1038/s41467-019-08659-3.


HTLV prevalence is no longer following the decreasing HIV prevalence - 20 years of retroviral surveillance in Guinea-Bissau, West Africa.

Jensen MM, Olesen JS, Kjerulff B, Byberg S, da Silva ZJ, Rodrigues A, Jespersen S, Wejse C, Aaby P, Erikstrup C, Hønge BL.

Acta Trop. 2019 Apr;192:144-150. doi: 10.1016/j.actatropica.2019.02.015. Epub 2019 Feb 13.


Correction: Political instability and supply-side barriers undermine the potential for high participation in HIV testing for the prevention of mother-to-child transmission in Guinea-Bissau: A retrospective cross-sectional study.

Rasmussen DN, Unger HW, Bjerregaard-Andersen M, da Silva Té D, Vieira N, Oliveira I, Hønge BL, Jespersen S, Gomes MA, Aaby P, Wejse C, Sodemann M.

PLoS One. 2019 Feb 7;14(2):e0212240. doi: 10.1371/journal.pone.0212240. eCollection 2019.


Opposite effects of Vaccinia and modified Vaccinia Ankara on trained immunity.

Blok BA, Jensen KJ, Aaby P, Fomsgaard A, van Crevel R, Benn CS, Netea MG.

Eur J Clin Microbiol Infect Dis. 2019 Mar;38(3):449-456. doi: 10.1007/s10096-018-03449-z. Epub 2019 Feb 5.


Maternal Priming: Bacillus Calmette-Guérin (BCG) Vaccine Scarring in Mothers Enhances the Survival of Their Child With a BCG Vaccine Scar.

Berendsen MLT, Øland CB, Bles P, Jensen AKG, Kofoed PE, Whittle H, De Bree C, Netea MG, Martins C, Benn CS, Aaby P.

J Pediatric Infect Dis Soc. 2019 Feb 3. doi: 10.1093/jpids/piy142. [Epub ahead of print]


Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau.

Hansen OB, Rodrigues A, Martins C, Rieckmann A, Benn CS, Aaby P, Fisker AB.

J Trop Pediatr. 2019 Oct 1;65(5):446-456. doi: 10.1093/tropej/fmy075.


Is the decline in neonatal mortality in northern Ghana, 1996-2012, associated with the decline in the age of BCG vaccination? An ecological study.

Welaga P, Debpuur C, Aaby P, Hodgson A, Azongo DK, Benn CS, Oduro AR.

BMJ Open. 2018 Dec 14;8(12):e023752. doi: 10.1136/bmjopen-2018-023752.


The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Park SE, Pham DT, Boinett C, Wong VK, Pak GD, Panzner U, Espinoza LMC, von Kalckreuth V, Im J, Schütt-Gerowitt H, Crump JA, Breiman RF, Adu-Sarkodie Y, Owusu-Dabo E, Rakotozandrindrainy R, Soura AB, Aseffa A, Gasmelseed N, Keddy KH, May J, Sow AG, Aaby P, Biggs HM, Hertz JT, Montgomery JM, Cosmas L, Olack B, Fields B, Sarpong N, Razafindrabe TJL, Raminosoa TM, Kabore LP, Sampo E, Teferi M, Yeshitela B, El Tayeb MA, Sooka A, Meyer CG, Krumkamp R, Dekker DM, Jaeger A, Poppert S, Tall A, Niang A, Bjerregaard-Andersen M, Løfberg SV, Seo HJ, Jeon HJ, Deerin JF, Park J, Konings F, Ali M, Clemens JD, Hughes P, Sendagala JN, Vudriko T, Downing R, Ikumapayi UN, Mackenzie GA, Obaro S, Argimon S, Aanensen DM, Page A, Keane JA, Duchene S, Dyson Z, Holt KE, Dougan G, Marks F, Baker S.

Nat Commun. 2018 Nov 30;9(1):5094. doi: 10.1038/s41467-018-07370-z.


Long-term effects of smallpox vaccination on expression of the HIV-1 co-receptor CCR5 in women.

Beck KB, Hønge BL, Olesen JS, Petersen MS, Jespersen S, Wejse C, da Silva ZJ, Medina C, Té DDS, Moeller BK, Benn CS, Aaby P, Erikstrup C.

PLoS One. 2018 Nov 15;13(11):e0207259. doi: 10.1371/journal.pone.0207259. eCollection 2018.


Corrigendum: Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice.

de Bree LCJ, Marijnissen RJ, Kel JM, Rosendahl Huber SK, Aaby P, Benn CS, Wijnands MVW, Diavatopoulos DA, van Crevel R, Joosten LAB, Netea MG, Dulos J.

Front Immunol. 2018 Oct 25;9:2471. doi: 10.3389/fimmu.2018.02471. eCollection 2018.


[Non-specific effects of vaccination in Denmark].

Benn CS, Aaby P, Særup S.

Ugeskr Laeger. 2018 Oct 29;180(44). pii: V07180467. Danish.


[Limited knowledge of the effect on child mortality of vaccinations and vitamin A supplementation].

Fisker AB, Thysen SM, Benn CS, Aaby P.

Ugeskr Laeger. 2018 Oct 29;180(44). pii: V06180465. Danish.


[Child mortality for children under five years of age declined seven fold in Guinea-Bissau over the latest 40 years].

Aaby P, Benn CS.

Ugeskr Laeger. 2018 Oct 29;180(44). pii: V07180470. Danish.


Maternal Measles Antibodies and Their Influence on All-cause Mortality Following Measles Vaccination: An Alternative to Measure Very Low Maternal Antibody Levels.

Smits G, Stabell Benn C, Whittle H, van Binnendijk R, Aaby P, van der Klis F.

Clin Infect Dis. 2019 May 2;68(10):1758-1760. doi: 10.1093/cid/ciy900.


Early BCG Vaccination, Hospitalizations, and Hospital Deaths: Analysis of a Secondary Outcome in 3 Randomized Trials from Guinea-Bissau.

Schaltz-Buchholzer F, Biering-Sørensen S, Lund N, Monteiro I, Umbasse P, Fisker AB, Andersen A, Rodrigues A, Aaby P, Benn CS.

J Infect Dis. 2019 Jan 29;219(4):624-632. doi: 10.1093/infdis/jiy544.


The impact of sex hormones on BCG-induced trained immunity.

de Bree LCJ, Janssen R, Aaby P, van Crevel R, Joosten LAB, Benn CS, Netea MG.

J Leukoc Biol. 2018 Sep;104(3):573-578. doi: 10.1002/JLB.5MA0118-027R.


Political instability and supply-side barriers undermine the potential for high participation in HIV testing for the prevention of mother-to-child transmission in Guinea-Bissau: A retrospective cross-sectional study.

Rasmussen DN, Unger HW, Bjerregaard-Andersen M, da Silva Té D, Vieira N, Oliveira I, Hønge BL, Jespersen S, Gomes MA, Aaby P, Wejse C, Sodemann M.

PLoS One. 2018 Aug 1;13(8):e0199819. doi: 10.1371/journal.pone.0199819. eCollection 2018. Erratum in: PLoS One. 2019 Feb 7;14(2):e0212240.


Admission and mortality at the main neonatal intensive care unit in Guinea-Bissau.

Pinstrup Joergensen AS, Bjerregaard-Andersen M, Biering-Sørensen S, Byberg S, Camala L, Martins C, Rodrigues A, Aaby P, Stabell Benn C.

Trans R Soc Trop Med Hyg. 2018 Jul 1;112(7):335-341. doi: 10.1093/trstmh/try061.


Non-specific effects of vaccines: Current evidence and potential implications.

de Bree LCJ, Koeken VACM, Joosten LAB, Aaby P, Benn CS, van Crevel R, Netea MG.

Semin Immunol. 2018 Oct;39:35-43. doi: 10.1016/j.smim.2018.06.002. Epub 2018 Jul 11. Review.


Revaccination With Measles-Mumps-Rubella Vaccine and Infectious Disease Morbidity: A Danish Register-based Cohort Study.

Sørup S, Jensen AKG, Aaby P, Benn CS.

Clin Infect Dis. 2019 Jan 7;68(2):282-290. doi: 10.1093/cid/ciy433.


Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice.

de Bree LCJ, Marijnissen RJ, Kel JM, Rosendahl Huber SK, Aaby P, Benn CS, Wijnands MVW, Diavatopoulos DA, van Crevel R, Joosten LAB, Netea MG, Dulos J.

Front Immunol. 2018 Apr 30;9:869. doi: 10.3389/fimmu.2018.00869. eCollection 2018. Erratum in: Front Immunol. 2018 Oct 25;9:2471.


How to evaluate potential non-specific effects of vaccines: the quest for randomized trials or time for triangulation?

Benn CS, Fisker AB, Rieckmann A, Jensen AKG, Aaby P.

Expert Rev Vaccines. 2018 May;17(5):411-420. doi: 10.1080/14760584.2018.1471987. Epub 2018 May 10. Review.


Where girls are less likely to be fully vaccinated than boys: Evidence from a rural area in Bangladesh.

Hanifi SMA, Ravn H, Aaby P, Bhuiya A.

Vaccine. 2018 May 31;36(23):3323-3330. doi: 10.1016/j.vaccine.2018.04.059. Epub 2018 Apr 24.


HIV-2 continues to decrease, whereas HIV-1 is stabilizing in Guinea-Bissau.

Olesen JS, Jespersen S, da Silva ZJ, Rodrigues A, Erikstrup C, Aaby P, Wejse C, Hønge BL.

AIDS. 2018 Jun 1;32(9):1193-1198. doi: 10.1097/QAD.0000000000001827.


BCG Vaccination at Birth and Rate of Hospitalization for Infection Until 15 Months of Age in Danish Children: A Randomized Clinical Multicenter Trial.

Stensballe LG, Ravn H, Birk NM, Kjærgaard J, Nissen TN, Pihl GT, Thøstesen LM, Greisen G, Jeppesen DL, Kofoed PE, Pryds O, Sørup S, Aaby P, Benn CS.

J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):213-220. doi: 10.1093/jpids/piy029.


Evidence of Increase in Mortality After the Introduction of Diphtheria-Tetanus-Pertussis Vaccine to Children Aged 6-35 Months in Guinea-Bissau: A Time for Reflection?

Aaby P, Mogensen SW, Rodrigues A, Benn CS.

Front Public Health. 2018 Mar 19;6:79. doi: 10.3389/fpubh.2018.00079. eCollection 2018.


Early BCG-Denmark and Neonatal Mortality Among Infants Weighing <2500 g: A Randomized Controlled Trial.

Biering-Sørensen S, Aaby P, Lund N, Monteiro I, Jensen KJ, Eriksen HB, Schaltz-Buchholzer F, Jørgensen ASP, Rodrigues A, Fisker AB, Benn CS.

Clin Infect Dis. 2017 Oct 1;65(7):1183-1190. doi: 10.1093/cid/cix525.


No effect of an additional early dose of measles vaccine on hospitalization or mortality in children: A randomized controlled trial.

Schoeps A, Nebié E, Fisker AB, Sié A, Zakane A, Müller O, Aaby P, Becher H.

Vaccine. 2018 Apr 5;36(15):1965-1971. doi: 10.1016/j.vaccine.2018.02.104. Epub 2018 Mar 6.


Measles Vaccination Supports Millennium Development Goal 4: Increasing Coverage and Increasing Child Survival in Northern Ghana, 1996-2012.

Welaga P, Hodgson A, Debpuur C, Aaby P, Binka F, Azongo D, Oduro A.

Front Public Health. 2018 Feb 12;6:28. doi: 10.3389/fpubh.2018.00028. eCollection 2018.


National Immunization Campaigns with Oral Polio Vaccine Reduce All-Cause Mortality: A Natural Experiment within Seven Randomized Trials.

Andersen A, Fisker AB, Rodrigues A, Martins C, Ravn H, Lund N, Biering-Sørensen S, Benn CS, Aaby P.

Front Public Health. 2018 Feb 2;6:13. doi: 10.3389/fpubh.2018.00013. eCollection 2018.


BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.

Arts RJW, Moorlag SJCFM, Novakovic B, Li Y, Wang SY, Oosting M, Kumar V, Xavier RJ, Wijmenga C, Joosten LAB, Reusken CBEM, Benn CS, Aaby P, Koopmans MP, Stunnenberg HG, van Crevel R, Netea MG.

Cell Host Microbe. 2018 Jan 10;23(1):89-100.e5. doi: 10.1016/j.chom.2017.12.010.


Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study.

Funch KM, Thysen SM, Rodrigues A, Martins CL, Aaby P, Benn CS, Fisker AB.

Hum Vaccin Immunother. 2018;14(10):2434-2442. doi: 10.1080/21645515.2017.1421879. Epub 2018 Jan 23.


Rapid Protective Effects of Early BCG on Neonatal Mortality Among Low Birth Weight Boys: Observations From Randomized Trials.

Biering-Sørensen S, Jensen KJ, Monterio I, Ravn H, Aaby P, Benn CS.

J Infect Dis. 2018 Feb 14;217(5):759-766. doi: 10.1093/infdis/jix612.


A Two-Center Randomized Trial of an Additional Early Dose of Measles Vaccine: Effects on Mortality and Measles Antibody Levels.

Fisker AB, Nebie E, Schoeps A, Martins C, Rodrigues A, Zakane A, Kagone M, Byberg S, Thysen SM, Tiendrebeogo J, Coulibaly B, Sankoh O, Becher H, Whittle HC, van der Klis FRM, Benn CS, Sie A, Müller O, Aaby P.

Clin Infect Dis. 2018 May 2;66(10):1573-1580. doi: 10.1093/cid/cix1033.


Long-term sex-differential effects of neonatal vitamin A supplementation on in vitro cytokine responses.

Jensen KJ, Søndergaard MJ, Andersen A, Martins C, Erikstrup C, Aaby P, Flanagan KL, Benn CS.

Br J Nutr. 2017 Dec;118(11):942-948. doi: 10.1017/S0007114517002938. Epub 2017 Nov 23.


Serious danger signals: Response to: The effect of neonatal vitamin A supplementation on morbidity and mortality at 12 months: a randomized trial.

Benn CS, Fisker AB, Aaby P.

Int J Epidemiol. 2017 Oct 1;46(5):1718-1720. doi: 10.1093/ije/dyx139. No abstract available.


Randomized Trial of 2 Versus 1 Dose of Measles Vaccine: Effect on Hospital Admission of Children After 9 Months of Age.

Brønd M, Martins CL, Byberg S, Benn CS, Whittle H, Garly ML, Aaby P, Fisker AB.

J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):226-233. doi: 10.1093/jpids/pix042.


Neonatal BCG vaccination and atopic dermatitis before 13 months of age: A randomized clinical trial.

Thøstesen LM, Kjaergaard J, Pihl GT, Birk NM, Nissen TN, Aaby P, Jensen AKG, Olesen AW, Stensballe LG, Jeppesen DL, Benn CS, Kofoed PE.

Allergy. 2018 Feb;73(2):498-504. doi: 10.1111/all.13314. Epub 2017 Oct 9.


Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation. A randomized clinical trial.

Nissen TN, Birk NM, Blok BA, Arts RJW, Andersen A, Kjærgaard J, Thøstesen LM, Hoffmann T, Jeppesen DL, Nielsen SD, Kofoed PE, Stensballe LG, Aaby P, Ruhwald M, Netea MG, Benn CS, Pryds O.

Eur J Clin Microbiol Infect Dis. 2018 Jan;37(1):29-41. doi: 10.1007/s10096-017-3097-2. Epub 2017 Sep 10.


Awareness, attitudes and perceptions regarding HIV and PMTCT amongst pregnant women in Guinea-Bissau- a qualitative study.

Vieira N, Rasmussen DN, Oliveira I, Gomes A, Aaby P, Wejse C, Sodemann M, Reynolds L, Unger HW.

BMC Womens Health. 2017 Sep 4;17(1):71. doi: 10.1186/s12905-017-0427-6.


The Effect of Smallpox and Bacillus Calmette-Guérin Vaccination on the Risk of Human Immunodeficiency Virus-1 Infection in Guinea-Bissau and Denmark.

Rieckmann A, Villumsen M, Jensen ML, Ravn H, da Silva ZJ, Sørup S, Baker JL, Rodrigues A, Benn CS, Roth AE, Aaby P.

Open Forum Infect Dis. 2017 Jun 20;4(3):ofx130. doi: 10.1093/ofid/ofx130. eCollection 2017 Summer.

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