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Items: 42

1.

Development and Validation of Hepamet Fibrosis Scoring System-a Simple, Non-invasive Test to Identify Patients With Nonalcoholic Fatty liver Disease With Advanced Fibrosis.

Ampuero J, Pais R, Aller R, Gallego-Durán R, Crespo J, García-Monzón C, Boursier J, Vilar E, Petta S, Ming-Hua Z, Escudero D, Calleja JL, Aspichueta P, Diago M, Rosales JM, Caballería J, Gómez-Camarero J, Lo Iacono O, Benlloch S, Albillos A, Turnes J, Banales JM, Ratziu V, Romero-Gómez M; HEPAmet Registry, Agustin S, Jorquera F, Frances R, Garcia-Samaniego J, Salmeron J, Fernandez-Rodriguez C, Estevez P, Andrade R, Soriano G, Fernandez-Bermejo M, Arias Loste MT, Sigüenza R, Giannetti A, Del Pozo Maroto E.

Clin Gastroenterol Hepatol. 2019 Jun 10. pii: S1542-3565(19)30602-0. doi: 10.1016/j.cgh.2019.05.051. [Epub ahead of print]

PMID:
31195161
2.

Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD).

Fernández Rodríguez CM, Aller R, Gutiérrez García ML, Ampuero J, Gómez-Camarero J, Martín-Mateos RMª, Burgos-Santamaría D, Rosales JM, Aspichueta P, Buque X, Latorre M, Andrade RJ, Hernández-Guerra M, Romero-Gómez M.

Rev Esp Enferm Dig. 2019 Apr;111(4):264-269. doi: 10.17235/reed.2019.5965/2018.

3.

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer.

Zubiete-Franco I, García-Rodríguez JL, Lopitz-Otsoa F, Serrano-Macia M, Simon J, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gutiérrez-de-Juan V, López de Davalillo S, Carlevaris O, Beguiristain Gómez A, Villa E, Calvisi D, Martín C, Berra E, Aspichueta P, Beraza N, Varela-Rey M, Ávila M, Rodríguez MS, Mato JM, Díaz-Moreno I, Díaz-Quintana A, Delgado TC, Martínez-Chantar ML.

EBioMedicine. 2019 Feb;40:406-421. doi: 10.1016/j.ebiom.2018.12.031. Epub 2018 Dec 26.

4.

p107 Deficiency Increases Energy Expenditure by Inducing Brown-Fat Thermogenesis and Browning of White Adipose Tissue.

Cunarro J, Buque X, Casado S, Lugilde J, Vidal A, Mora A, Sabio G, Nogueiras R, Aspichueta P, Diéguez C, Tovar S.

Mol Nutr Food Res. 2019 Jan;63(2):e1801096. doi: 10.1002/mnfr.201801096. Epub 2018 Nov 14.

PMID:
30383332
5.

The effects of metabolic status on non-alcoholic fatty liver disease-related outcomes, beyond the presence of obesity.

Ampuero J, Aller R, Gallego-Durán R, Banales JM, Crespo J, García-Monzón C, Pareja MJ, Vilar-Gómez E, Caballería J, Escudero-García D, Gomez-Camarero J, Calleja JL, Latorre M, Albillos A, Salmeron J, Aspichueta P, Lo Iacono O, Francés R, Benlloch S, Fernández-Rodríguez C, García-Samaniego J, Estévez P, Andrade RJ, Turnes J, Romero-Gómez M; HEPAmet Registry.

Aliment Pharmacol Ther. 2018 Dec;48(11-12):1260-1270. doi: 10.1111/apt.15015. Epub 2018 Oct 23.

PMID:
30353552
6.

Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice.

Nuñez-Garcia M, Gomez-Santos B, Saenz de Urturi D, Mestre D, Gonzalez-Romero F, Buque X, Gutiérrez-de Juan V, Martinez-Chantar ML, Syn WK, Fresnedo O, Aspichueta P.

Sci Rep. 2018 Oct 2;8(1):14626. doi: 10.1038/s41598-018-32919-9.

7.

Lipid-rich environment: a key role promoting carcinogenesis in obesity-related non-alcoholic fatty liver disease.

Aspichueta P.

Gut. 2018 Aug;67(8):1376-1377. doi: 10.1136/gutjnl-2018-316047. Epub 2018 Mar 14. No abstract available.

PMID:
29540438
8.

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.

Porteiro B, Fondevila MF, Buque X, Gonzalez-Rellan MJ, Fernandez U, Mora A, Beiroa D, Senra A, Gallego R, Fernø J, López M, Sabio G, Dieguez C, Aspichueta P, Nogueiras R.

Mol Metab. 2018 Feb;8:132-143. doi: 10.1016/j.molmet.2017.12.005. Epub 2017 Dec 15.

9.

Role of Aramchol in steatohepatitis and fibrosis in mice.

Iruarrizaga-Lejarreta M, Varela-Rey M, Fernández-Ramos D, Martínez-Arranz I, Delgado TC, Simon J, Juan VG, delaCruz-Villar L, Azkargorta M, Lavin JL, Mayo R, Van Liempd SM, Aurrekoetxea I, Buqué X, Cave DD, Peña A, Rodríguez-Cuesta J, Aransay AM, Elortza F, Falcón-Pérez JM, Aspichueta P, Hayardeny L, Noureddin M, Sanyal AJ, Alonso C, Anguita J, Martínez-Chantar ML, Lu SC, Mato JM.

Hepatol Commun. 2017 Nov;1(9):911-927. doi: 10.1002/hep4.1107. Epub 2017 Oct 4.

10.

The Retina of Osteopontin deficient Mice in Aging.

Ruzafa N, Pereiro X, Aspichueta P, Araiz J, Vecino E.

Mol Neurobiol. 2018 Jan;55(1):213-221. doi: 10.1007/s12035-017-0734-9.

11.

Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver.

Nuñez-Garcia M, Gomez-Santos B, Buqué X, García-Rodriguez JL, Romero MR, Marin JJG, Arteta B, García-Monzón C, Castaño L, Syn WK, Fresnedo O, Aspichueta P.

J Lipid Res. 2017 Sep;58(9):1903-1915. doi: 10.1194/jlr.M078980. Epub 2017 Jul 28.

12.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

13.

Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress.

Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R.

Nat Commun. 2017 Jun 16;8:16059. doi: 10.1038/ncomms16059.

14.

Hepatic p63 regulates steatosis via IKKβ/ER stress.

Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R.

Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Erratum in: Nat Commun. 2017 Jun 16;8:16059.

15.

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Abulizi A, Perry RJ, Camporez JPG, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI.

FASEB J. 2017 Jul;31(7):2916-2924. doi: 10.1096/fj.201700001R. Epub 2017 Mar 22.

16.

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

Alonso C, Fernández-Ramos D, Varela-Rey M, Martínez-Arranz I, Navasa N, Van Liempd SM, Lavín Trueba JL, Mayo R, Ilisso CP, de Juan VG, Iruarrizaga-Lejarreta M, delaCruz-Villar L, Mincholé I, Robinson A, Crespo J, Martín-Duce A, Romero-Gómez M, Sann H, Platon J, Van Eyk J, Aspichueta P, Noureddin M, Falcón-Pérez JM, Anguita J, Aransay AM, Martínez-Chantar ML, Lu SC, Mato JM.

Gastroenterology. 2017 May;152(6):1449-1461.e7. doi: 10.1053/j.gastro.2017.01.015. Epub 2017 Jan 26.

17.

Deregulated neddylation in liver fibrosis.

Zubiete-Franco I, Fernández-Tussy P, Barbier-Torres L, Simon J, Fernández-Ramos D, Lopitz-Otsoa F, Gutiérrez-de Juan V, de Davalillo SL, Duce AM, Iruzubieta P, Taibo D, Crespo J, Caballeria J, Villa E, Aurrekoetxea I, Aspichueta P, Varela-Rey M, Lu SC, Mato JM, Beraza N, Delgado TC, Martínez-Chantar ML.

Hepatology. 2017 Feb;65(2):694-709. doi: 10.1002/hep.28933. Epub 2016 Dec 30.

18.

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.

Zubiete-Franco I, García-Rodríguez JL, Martínez-Uña M, Martínez-Lopez N, Woodhoo A, Juan VG, Beraza N, Lage-Medina S, Andrade F, Fernandez ML, Aldámiz-Echevarría L, Fernández-Ramos D, Falcon-Perez JM, Lopitz-Otsoa F, Fernandez-Tussy P, Barbier-Torres L, Luka Z, Wagner C, García-Monzón C, Lu SC, Aspichueta P, Mato JM, Martínez-Chantar ML, Varela-Rey M.

J Hepatol. 2016 Feb;64(2):409-418. doi: 10.1016/j.jhep.2015.08.037. Epub 2015 Sep 21.

19.

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.

Gomez-Sanchez JA, Carty L, Iruarrizaga-Lejarreta M, Palomo-Irigoyen M, Varela-Rey M, Griffith M, Hantke J, Macias-Camara N, Azkargorta M, Aurrekoetxea I, De Juan VG, Jefferies HB, Aspichueta P, Elortza F, Aransay AM, Martínez-Chantar ML, Baas F, Mato JM, Mirsky R, Woodhoo A, Jessen KR.

J Cell Biol. 2015 Jul 6;210(1):153-68. doi: 10.1083/jcb.201503019.

20.

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.

Barbier-Torres L, Delgado TC, García-Rodríguez JL, Zubiete-Franco I, Fernández-Ramos D, Buqué X, Cano A, Gutiérrez-de Juan V, Fernández-Domínguez I, Lopitz-Otsoa F, Fernández-Tussy P, Boix L, Bruix J, Villa E, Castro A, Lu SC, Aspichueta P, Xirodimas D, Varela-Rey M, Mato JM, Beraza N, Martínez-Chantar ML.

Oncotarget. 2015 Feb 10;6(4):2509-23.

21.

S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.

Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P.

J Hepatol. 2015 Mar;62(3):673-81. doi: 10.1016/j.jhep.2014.10.019. Epub 2014 Oct 18.

22.

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.

García-Rodríguez JL, Barbier-Torres L, Fernández-Álvarez S, Gutiérrez-de Juan V, Monte MJ, Halilbasic E, Herranz D, Álvarez L, Aspichueta P, Marín JJ, Trauner M, Mato JM, Serrano M, Beraza N, Martínez-Chantar ML.

Hepatology. 2014 May;59(5):1972-83. doi: 10.1002/hep.26971. Epub 2014 Mar 31.

23.

Involvement of lipid droplets in hepatic responses to lipopolysaccharide treatment in mice.

Arisqueta L, Nuñez-Garcia M, Ogando J, Garcia-Arcos I, Ochoa B, Aspichueta P, Fresnedo O, Rueda Y.

Biochim Biophys Acta. 2013 Aug;1831(8):1357-67. doi: 10.1016/j.bbalip.2013.04.015. Epub 2013 May 9.

PMID:
23665317
24.

Infection of primary hepatocytes with adenoviral vectors alters biliary lipid metabolism.

Rueda Y, Garcia-Arcos I, Aspichueta P, Ochoa B, Palacios L, Fresnedo O.

J Physiol Sci. 2013 May;63(3):225-9. doi: 10.1007/s12576-013-0260-0. Epub 2013 Apr 5.

PMID:
23558863
25.

Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.

Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM.

Hepatology. 2013 Oct;58(4):1296-305. doi: 10.1002/hep.26399. Epub 2013 Aug 14.

26.

Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.

Vazquez-Chantada M, Gonzalez-Lahera A, Martinez-Arranz I, Garcia-Monzon C, Regueiro MM, Garcia-Rodriguez JL, Schlangen KA, Mendibil I, Rodriguez-Ezpeleta N, Lozano JJ, Banasik K, Justesen JM, Joergensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Veyrie N, Clement K, Tordjman J, Tran A, Le Marchand-Brustel Y, Buque X, Aspichueta P, Echevarria-Uraga JJ, Martin-Duce A, Caballeria J, Gual P, Castro A, Mato JM, Martinez-Chantar ML, Aransay AM.

Hepatology. 2013 Feb;57(2):505-14. doi: 10.1002/hep.26052. Epub 2012 Nov 27.

PMID:
22961556
27.

High insulin levels are required for FAT/CD36 plasma membrane translocation and enhanced fatty acid uptake in obese Zucker rat hepatocytes.

Buqué X, Cano A, Miquilena-Colina ME, García-Monzón C, Ochoa B, Aspichueta P.

Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E504-14. doi: 10.1152/ajpendo.00653.2011. Epub 2012 Jun 12.

28.

Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.

Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML.

Gastroenterology. 2012 Sep;143(3):787-798.e13. doi: 10.1053/j.gastro.2012.05.050. Epub 2012 Jun 8.

29.

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice.

Cano A, Buqué X, Martínez-Uña M, Aurrekoetxea I, Menor A, García-Rodríguez JL, Lu SC, Martínez-Chantar ML, Mato JM, Ochoa B, Aspichueta P.

Hepatology. 2011 Dec;54(6):1975-86. doi: 10.1002/hep.24607.

30.

High fat diet-induced non alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway.

Bravo E, Palleschi S, Aspichueta P, Buqué X, Rossi B, Cano A, Napolitano M, Ochoa B, Botham KM.

Lipids Health Dis. 2011 Apr 19;10:60. doi: 10.1186/1476-511X-10-60.

31.

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.

Miquilena-Colina ME, Lima-Cabello E, Sánchez-Campos S, García-Mediavilla MV, Fernández-Bermejo M, Lozano-Rodríguez T, Vargas-Castrillón J, Buqué X, Ochoa B, Aspichueta P, González-Gallego J, García-Monzón C.

Gut. 2011 Oct;60(10):1394-402. doi: 10.1136/gut.2010.222844. Epub 2011 Jan 26.

PMID:
21270117
32.

Biphasic adaptative responses in VLDL metabolism and lipoprotein homeostasis during Gram-negative endotoxemia.

Bartolomé N, Aspichueta P, Martínez MJ, Vázquez-Chantada M, Martínez-Chantar ML, Ochoa B, Chico Y.

Innate Immun. 2012 Feb;18(1):89-99. doi: 10.1177/1753425910390722. Epub 2010 Nov 26.

PMID:
21113081
33.

Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets.

García-Arcos I, González-Kother P, Aspichueta P, Rueda Y, Ochoa B, Fresnedo O.

Lipids. 2010 Dec;45(12):1101-8. doi: 10.1007/s11745-010-3492-2. Epub 2010 Nov 10.

PMID:
21063798
34.

A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats.

Buqué X, Martínez MJ, Cano A, Miquilena-Colina ME, García-Monzón C, Aspichueta P, Ochoa B.

J Lipid Res. 2010 Mar;51(3):500-13. doi: 10.1194/jlr.M001966. Epub 2009 Sep 24.

35.

Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q?

Cano A, Ciaffoni F, Safwat GM, Aspichueta P, Ochoa B, Bravo E, Botham KM.

J Appl Physiol (1985). 2009 Sep;107(3):707-17. doi: 10.1152/japplphysiol.00297.2009. Epub 2009 Jul 16.

36.

[Molecular basis of obesity-related hepatic steatosis].

Buqué X, Aspichueta P, Ochoa B.

Rev Esp Enferm Dig. 2008 Sep;100(9):565-78. Spanish.

37.

Impaired response of VLDL lipid and apoB secretion to endotoxin in the fasted rat liver.

Aspichueta P, Pérez-Agote B, Pérez S, Ochoa B, Fresnedo O.

J Endotoxin Res. 2006;12(3):181-92.

PMID:
16719989
38.

The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes.

Pérez S, Aspichueta P, Ochoa B, Chico Y.

Biochim Biophys Acta. 2006 Feb;1761(2):160-71. Epub 2006 Mar 3.

PMID:
16545597
39.

Endotoxin promotes preferential periportal upregulation of VLDL secretion in the rat liver.

Aspichueta P, Pérez S, Ochoa B, Fresnedo O.

J Lipid Res. 2005 May;46(5):1017-26. Epub 2005 Feb 16.

40.

Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes.

Pérez S, Maldonado EN, Aspichueta P, Ochoa B, Chico Y.

Mol Cell Biochem. 2004 Nov;266(1-2):183-9.

PMID:
15646041
41.

Short- and long-term effects of atorvastatin, lovastatin and simvastatin on the cellular metabolism of cholesteryl esters and VLDL secretion in rat hepatocytes.

Isusi E, Aspichueta P, Liza M, Hernández ML, Díaz C, Hernández G, Martínez MJ, Ochoa B.

Atherosclerosis. 2000 Dec;153(2):283-94.

PMID:
11164417
42.

The formation and secretion of cholesteryl esters in rat hepatocytes are reduced by lovastatin and simvastatin.

Martínez MJ, Hernández ML, Isusi E, Aspichueta P, Ochoa B.

Biochem Soc Trans. 1998 Feb;26(1):S82. No abstract available.

PMID:
10909840

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