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Cell Metab. 2006 Jul;4(1):5-6.

APPLied mechanics: uncovering how adiponectin modulates insulin action.

Author information

1
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA.

Abstract

Adiponectin, an adipocyte secretory hormone, has been causally linked to insulin resistance in the metabolic syndrome and diabetes. A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.

PMID:
16814726
DOI:
10.1016/j.cmet.2006.06.003
[Indexed for MEDLINE]
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