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Items: 1 to 50 of 205

1.

Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease.

Kleine Holthaus SM, Herranz-Martin S, Massaro G, Aristorena M, Hoke J, Hughes MP, Maswood R, Semenyuk O, Basche M, Shah AZ, Klaska IP, Smith AJ, Mole SE, Rahim AA, Ali RR.

Hum Mol Genet. 2019 Sep 6. pii: ddz210. doi: 10.1093/hmg/ddz210. [Epub ahead of print]

PMID:
31807779
2.

Rapid urbanisation threatens fertile agricultural land and soil carbon in the Nile delta.

Abd-Elmabod SK, Fitch AC, Zhang Z, Ali RR, Jones L.

J Environ Manage. 2019 Dec 15;252:109668. doi: 10.1016/j.jenvman.2019.109668. Epub 2019 Oct 8.

PMID:
31604185
3.

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia.

Villacampa P, Liyanage SE, Klaska IP, Cristante E, Menger KE, Sampson RD, Barlow M, Abelleira-Hervas L, Duran Y, Smith AJ, Ali RR, Luhmann UFO, Bainbridge JWB.

Angiogenesis. 2019 Oct 3. doi: 10.1007/s10456-019-09681-1. [Epub ahead of print]

PMID:
31583505
4.

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material.

Zhang Q, Presswalla F, Calton M, Charniga C, Stern J, Temple S, Vollrath D, Zacks DN, Ali RR, Thompson DA, Miller JML.

Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3468-3479. doi: 10.1167/iovs.19-26690.

5.

Modulation of Contact Inhibition by ZO-1/ZONAB Gene Transfer-A New Strategy to Increase the Endothelial Cell Density of Corneal Grafts.

Kampik D, Basche M, Georgiadis A, Luhmann UFO, Larkin DF, Smith AJ, Ali RR.

Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3170-3177. doi: 10.1167/iovs.18-26260.

PMID:
31335954
6.

Development of a Gene Therapy Vector for RDH12-Associated Retinal Dystrophy.

Feathers KL, Jia L, Perera ND, Chen A, Presswalla FK, Khan NW, Fahim AT, Smith AJ, Ali RR, Thompson DA.

Hum Gene Ther. 2019 Nov;30(11):1325-1335. doi: 10.1089/hum.2019.017. Epub 2019 Aug 5.

PMID:
31237438
7.

Detailed clinical characterisation, unique features and natural history of autosomal recessive RDH12-associated retinal degeneration.

Fahim AT, Bouzia Z, Branham KH, Kumaran N, Vargas ME, Feathers KL, Perera ND, Young K, Khan NW, Heckenlively JR, Webster AR, Pennesi ME, Ali RR, Thompson DA, Michaelides M.

Br J Ophthalmol. 2019 Dec;103(12):1789-1796. doi: 10.1136/bjophthalmol-2018-313580. Epub 2019 Apr 12.

PMID:
30979730
8.

Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.

Aldunate EZ, Di Foggia V, Di Marco F, Hervas LA, Ribeiro JC, Holder DL, Patel A, Jannini TB, Thompson DA, Martinez-Barbera JP, Pearson RA, Ali RR, Sowden JC.

Sci Rep. 2019 Feb 19;9(1):2314. doi: 10.1038/s41598-018-38294-9.

9.
10.

Unlocking the Potential for Endogenous Repair to Restore Sight.

Pearson RA, Ali RR.

Neuron. 2018 Nov 7;100(3):524-526. doi: 10.1016/j.neuron.2018.10.035. Review.

11.

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M.

Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y.

12.

Regenerating Eye Tissues to Preserve and Restore Vision.

Stern JH, Tian Y, Funderburgh J, Pellegrini G, Zhang K, Goldberg JL, Ali RR, Young M, Xie Y, Temple S.

Cell Stem Cell. 2018 Sep 6;23(3):453. doi: 10.1016/j.stem.2018.08.014. No abstract available.

13.

Sustained and Widespread Gene Delivery to the Corneal Epithelium via In Situ Transduction of Limbal Epithelial Stem Cells, Using Lentiviral and Adeno-Associated Viral Vectors.

Basche M, Kampik D, Kawasaki S, Branch MJ, Robinson M, Larkin DF, Smith AJ, Ali RR.

Hum Gene Ther. 2018 Oct;29(10):1140-1152. doi: 10.1089/hum.2018.115. Epub 2018 Sep 14.

PMID:
30070149
14.

Correction: Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65.

Georgiadis A, Duran Y, Ribeiro J, Abelleira-Hervas L, Robbie SJ, Sünkel-Laing B, Fourali S, Gonzalez-Cordero A, Cristante E, Michaelides M, Bainbridge JWB, Smith AJ, Ali RR.

Gene Ther. 2018 Sep;25(6):450. doi: 10.1038/s41434-018-0031-x.

15.

Use of bioreactors for culturing human retinal organoids improves photoreceptor yields.

Ovando-Roche P, West EL, Branch MJ, Sampson RD, Fernando M, Munro P, Georgiadis A, Rizzi M, Kloc M, Naeem A, Ribeiro J, Smith AJ, Gonzalez-Cordero A, Ali RR.

Stem Cell Res Ther. 2018 Jun 13;9(1):156. doi: 10.1186/s13287-018-0907-0.

16.

Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration.

Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, Robinson M, Rosenthal AN, Innes W, Weleber RG, Lee RWJ, Crossland M, Rubin GS, Dhillon B, Steel DHW, Anglade E, Lanza RP, Ali RR, Michaelides M, Bainbridge JWB.

Ophthalmology. 2018 Nov;125(11):1765-1775. doi: 10.1016/j.ophtha.2018.04.037. Epub 2018 Jun 5.

17.

Regenerating Eye Tissues to Preserve and Restore Vision.

Stern JH, Tian Y, Funderburgh J, Pellegrini G, Zhang K, Goldberg JL, Ali RR, Young M, Xie Y, Temple S.

Cell Stem Cell. 2018 Jun 1;22(6):834-849. doi: 10.1016/j.stem.2018.05.013. Review. Erratum in: Cell Stem Cell. 2018 Sep 6;23(3):453.

18.

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E.

Brain. 2018 Jul 1;141(7):2014-2031. doi: 10.1093/brain/awy126.

19.

Gene Therapy Approaches to Treat the Neurodegeneration and Visual Failure in Neuronal Ceroid Lipofuscinoses.

Kleine Holthaus SM, Smith AJ, Mole SE, Ali RR.

Adv Exp Med Biol. 2018;1074:91-99. doi: 10.1007/978-3-319-75402-4_12. Review.

PMID:
29721932
20.

Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner.

Cristante E, Liyanage SE, Sampson RD, Kalargyrou A, De Rossi G, Rizzi M, Hoke J, Ribeiro J, Maswood RN, Duran Y, Matsuki T, Aghaizu ND, Luhmann UF, Smith AJ, Ali RR, Bainbridge JWB.

Development. 2018 Apr 25;145(8). pii: dev157511. doi: 10.1242/dev.157511.

21.

Prevention of Photoreceptor Cell Loss in a Cln6nclf Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells.

Kleine Holthaus SM, Ribeiro J, Abelleira-Hervas L, Pearson RA, Duran Y, Georgiadis A, Sampson RD, Rizzi M, Hoke J, Maswood R, Azam S, Luhmann UFO, Smith AJ, Mole SE, Ali RR.

Mol Ther. 2018 May 2;26(5):1343-1353. doi: 10.1016/j.ymthe.2018.02.027. Epub 2018 Mar 2.

22.

Assessment of AAV Vector Tropisms for Mouse and Human Pluripotent Stem Cell-Derived RPE and Photoreceptor Cells.

Gonzalez-Cordero A, Goh D, Kruczek K, Naeem A, Fernando M, Kleine Holthaus SM, Takaaki M, Blackford SJI, Kloc M, Agundez L, Sampson RD, Borooah S, Ovando-Roche P, Mehat MS, West EL, Smith AJ, Pearson RA, Ali RR.

Hum Gene Ther. 2018 Oct;29(10):1124-1139. doi: 10.1089/hum.2018.027. Epub 2018 May 14.

PMID:
29580100
23.

Retinal gene therapy.

Kumaran N, Michaelides M, Smith AJ, Ali RR, Bainbridge JWB.

Br Med Bull. 2018 Jun 1;126(1):13-25. doi: 10.1093/bmb/ldy005. Review.

PMID:
29506236
24.

Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae.

Lakowski J, Welby E, Budinger D, Di Marco F, Di Foggia V, Bainbridge JWB, Wallace K, Gamm DM, Ali RR, Sowden JC.

Stem Cells. 2018 May;36(5):709-722. doi: 10.1002/stem.2775. Epub 2018 Feb 1.

25.

Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner.

Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou AA, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Zabala Aldunate E, Sampson RD, Bainbridge JWB, Smith AJ, Gonzalez-Cordero A, Sowden JC, Ali RR, Pearson RA.

Stem Cell Reports. 2018 Feb 13;10(2):406-421. doi: 10.1016/j.stemcr.2017.12.008. Epub 2018 Jan 4.

26.

In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations.

Kampik D, Basche M, Luhmann UFO, Nishiguchi KM, Williams JAE, Greenwood J, Moss SE, Han H, Azam S, Duran Y, Robbie SJ, Bainbridge JWB, Larkin DF, Smith AJ, Ali RR.

Gene Ther. 2017 Dec;24(12):810-818. doi: 10.1038/gt.2017.89. Epub 2017 Nov 30.

PMID:
29188796
27.

Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.

Welby E, Lakowski J, Di Foggia V, Budinger D, Gonzalez-Cordero A, Lun ATL, Epstein M, Patel A, Cuevas E, Kruczek K, Naeem A, Minneci F, Hubank M, Jones DT, Marioni JC, Ali RR, Sowden JC.

Stem Cell Reports. 2017 Dec 12;9(6):1898-1915. doi: 10.1016/j.stemcr.2017.10.018. Epub 2017 Nov 16.

28.

Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH.

Sci Rep. 2017 Nov 7;7(1):14625. doi: 10.1038/s41598-017-15212-z.

29.

Augmenting Endogenous Levels of Retinal Annexin A1 Suppresses Uveitis in Mice.

Gardner PJ, Yazid S, Ribeiro J, Ali RR, Dick AD.

Transl Vis Sci Technol. 2017 Oct 5;6(5):10. doi: 10.1167/tvst.6.5.10. eCollection 2017 Sep.

30.

Celebrating 25 Years of the European Society of Gene and Cell Therapy.

Ali RR, Büning H.

Hum Gene Ther. 2017 Nov;28(11):939. doi: 10.1089/hum.2017.29054.rra. No abstract available.

PMID:
29035112
31.

Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.

Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford SJI, Abelleira-Hervas L, Sampson RD, Shum IO, Branch MJ, Gardner PJ, Sowden JC, Bainbridge JWB, Smith AJ, West EL, Pearson RA, Ali RR.

Stem Cell Reports. 2017 Sep 12;9(3):820-837. doi: 10.1016/j.stemcr.2017.07.022. Epub 2017 Aug 24.

32.

The Future Looks Brighter After 25 Years of Retinal Gene Therapy.

Auricchio A, Smith AJ, Ali RR.

Hum Gene Ther. 2017 Nov;28(11):982-987. doi: 10.1089/hum.2017.164. Epub 2017 Aug 20. Review.

PMID:
28825330
33.

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs.

Mowat FM, Gervais KJ, Occelli LM, Annear MJ, Querubin J, Bainbridge JW, Smith AJ, Ali RR, Petersen-Jones SM.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3268-3277. doi: 10.1167/iovs.17-21930.

PMID:
28662231
34.

Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization.

Villacampa P, Menger KE, Abelleira L, Ribeiro J, Duran Y, Smith AJ, Ali RR, Luhmann UF, Bainbridge JWB.

PLoS One. 2017 Jun 26;12(6):e0179759. doi: 10.1371/journal.pone.0179759. eCollection 2017.

35.

Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration.

Ovando-Roche P, Georgiadis A, Smith AJ, Pearson RA, Ali RR.

Curr Stem Cell Rep. 2017;3(2):112-123. doi: 10.1007/s40778-017-0078-4. Epub 2017 Apr 18. Review.

36.

Pluripotent stem cells and their utility in treating photoreceptor degenerations.

Aghaizu ND, Kruczek K, Gonzalez-Cordero A, Ali RR, Pearson RA.

Prog Brain Res. 2017;231:191-223. doi: 10.1016/bs.pbr.2017.01.001. Epub 2017 Mar 21.

PMID:
28554397
37.

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration.

Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, Kloc M, Duran Y, Georgiadis A, Sampson RD, Maswood RN, Smith AJ, Decembrini S, Arsenijevic Y, Sowden JC, Pearson RA, West EL, Ali RR.

Stem Cell Reports. 2017 Jun 6;8(6):1659-1674. doi: 10.1016/j.stemcr.2017.04.030. Epub 2017 May 25.

38.

Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.

Gardner PJ, Liyanage SE, Cristante E, Sampson RD, Dick AD, Ali RR, Bainbridge JW.

Sci Rep. 2017 Jan 23;7:40830. doi: 10.1038/srep40830.

39.

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.

Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME.

Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.

40.

Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.

Pearson RA, Gonzalez-Cordero A, West EL, Ribeiro JR, Aghaizu N, Goh D, Sampson RD, Georgiadis A, Waldron PV, Duran Y, Naeem A, Kloc M, Cristante E, Kruczek K, Warre-Cornish K, Sowden JC, Smith AJ, Ali RR.

Nat Commun. 2016 Oct 4;7:13029. doi: 10.1038/ncomms13029.

41.

Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65.

Georgiadis A, Duran Y, Ribeiro J, Abelleira-Hervas L, Robbie SJ, Sünkel-Laing B, Fourali S, Gonzalez-Cordero A, Cristante E, Michaelides M, Bainbridge JW, Smith AJ, Ali RR.

Gene Ther. 2016 Dec;23(12):857-862. doi: 10.1038/gt.2016.66. Epub 2016 Sep 22. Erratum in: Gene Ther. 2018 Sep;25(6):450.

42.

Conventional versus Doxorubicin-Eluting Beads Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: a Tertiary Medical Centre Experience in Malaysia.

Rahman FA, Naidu J, Ngiu CS, Yaakob Y, Mohamed Z, Othman H, Jarmin R, Elias MH, Hamid NA, Mokhtar NM, Ali RR.

Asian Pac J Cancer Prev. 2016;17(8):4037-41.

43.

Impact of BREXIT on UK Gene and Cell Therapy: The Need for Continued Pan-European Collaboration.

Baker AH, Ali RR, Thrasher AJ.

Hum Gene Ther. 2016 Sep;27(9):653-5. doi: 10.1089/hum.2016.29033.ahb. No abstract available.

PMID:
27622542
44.

Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.

Liyanage SE, Gardner PJ, Ribeiro J, Cristante E, Sampson RD, Luhmann UF, Ali RR, Bainbridge JW.

Exp Eye Res. 2016 Oct;151:160-70. doi: 10.1016/j.exer.2016.08.007. Epub 2016 Aug 18.

45.

Investigation of SLA4A3 as a candidate gene for human retinal disease.

Downs LM, Webster AR, Moore AT, Michaelides M, Ali RR, Hardcastle AJ, Mellersh CS.

J Negat Results Biomed. 2016 May 23;15:11. doi: 10.1186/s12952-016-0054-z.

46.

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement.

Di Foggia V, Makwana P, Ali RR, Sowden JC.

J Ocul Pharmacol Ther. 2016 Jun;32(5):240-52. doi: 10.1089/jop.2015.0143. Epub 2016 Mar 30. Review.

47.

Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging.

Robbie SJ, Georgiadis A, Barker SE, Duran Y, Smith AJ, Ali RR, Luhmann UFO, Bainbridge JW.

Neurobiol Aging. 2016 Apr;40:110-119. doi: 10.1016/j.neurobiolaging.2015.12.019. Epub 2016 Jan 4.

PMID:
26973110
48.

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

Chu CJ, Gardner PJ, Copland DA, Liyanage SE, Gonzalez-Cordero A, Kleine Holthaus SM, Luhmann UF, Smith AJ, Ali RR, Dick AD.

Dis Model Mech. 2016 Apr;9(4):473-81. doi: 10.1242/dmm.022475. Epub 2016 Jan 21.

49.

Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy.

Ripamonti C, Henning GB, Robbie SJ, Sundaram V, van den Born LI, Casteels I, de Ravel TJ, Moore AT, Smith AJ, Bainbridge JW, Ali RR, Stockman A.

J Vis. 2015;15(15):20. doi: 10.1167/15.15.20.

PMID:
26605849
50.

Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report.

Liyanage SE, Fantin A, Villacampa P, Lange CA, Denti L, Cristante E, Smith AJ, Ali RR, Luhmann UF, Bainbridge JW, Ruhrberg C.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):19-24. doi: 10.1161/ATVBAHA.115.306681. Epub 2015 Nov 24.

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