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Items: 1 to 50 of 145

1.

Redox states of hemoglobin determine left ventricle pressure recovery and activity of mitochondrial complex IV in hypoxic rat hearts.

Edmondson M, Jana S, Meng F, Strader MB, Baek JH, Gao Y, Buehler PW, Alayash AI.

Free Radic Biol Med. 2019 Jul 11;141:348-361. doi: 10.1016/j.freeradbiomed.2019.07.008. [Epub ahead of print]

PMID:
31302228
2.

Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.

Strader MB, Liang H, Meng F, Harper J, Ostrowski DA, Henry ER, Shet AS, Eaton WA, Thein SL, Alayash AI.

Bioconjug Chem. 2019 Mar 20;30(3):568-571. doi: 10.1021/acs.bioconjchem.9b00130. Epub 2019 Feb 28.

PMID:
30794381
3.

Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation.

Meng F, Kassa T, Strader MB, Soman J, Olson JS, Alayash AI.

J Biol Chem. 2019 Mar 15;294(11):4145-4159. doi: 10.1074/jbc.RA118.006452. Epub 2019 Jan 10.

4.

Voxelotor treatment of a patient with sickle cell disease and very severe anemia.

Shet AS, Mendelsohn L, Harper J, Ostrowski D, Henry ER, Gwaabe E, Nichols J, Alayash AI, Eaton WA, Thein SL.

Am J Hematol. 2019 Apr;94(4):E88-E90. doi: 10.1002/ajh.25389. Epub 2019 Jan 8. No abstract available.

PMID:
30592074
5.

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles.

Jana S, Strader MB, Meng F, Hicks W, Kassa T, Tarandovskiy I, De Paoli S, Simak J, Heaven MR, Belcher JD, Vercellotti GM, Alayash AI.

JCI Insight. 2018 Nov 2;3(21). pii: 120451. doi: 10.1172/jci.insight.120451.

6.

Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin.

Kettisen K, Strader MB, Wood F, Alayash AI, Bülow L.

Redox Biol. 2018 Oct;19:218-225. doi: 10.1016/j.redox.2018.08.010. Epub 2018 Aug 22.

7.

Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers.

Simons M, Gretton S, Silkstone GGA, Rajagopal BS, Allen-Baume V, Syrett N, Shaik T, Leiva-Eriksson N, Ronda L, Mozzarelli A, Strader MB, Alayash AI, Reeder BJ, Cooper CE.

Biosci Rep. 2018 Jul 2;38(4). pii: BSR20180370. doi: 10.1042/BSR20180370. Print 2018 Aug 31.

8.

Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally.

Meng F, Kassa T, Jana S, Wood F, Zhang X, Jia Y, D'Agnillo F, Alayash AI.

Bioconjug Chem. 2018 May 16;29(5):1560-1575. doi: 10.1021/acs.bioconjchem.8b00093. Epub 2018 Apr 2.

PMID:
29570272
9.

Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome.

De Paoli SH, Tegegn TZ, Elhelu OK, Strader MB, Patel M, Diduch LL, Tarandovskiy ID, Wu Y, Zheng J, Ovanesov MV, Alayash A, Simak J.

Cell Mol Life Sci. 2018 Oct;75(20):3781-3801. doi: 10.1007/s00018-018-2771-6. Epub 2018 Feb 9.

PMID:
29427073
10.

Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells.

Jana S, Meng F, Hirsch RE, Friedman JM, Alayash AI.

Front Physiol. 2017 Dec 19;8:1082. doi: 10.3389/fphys.2017.01082. eCollection 2017.

11.

Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.

Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM.

Transfusion. 2018 Jan;58(1):255-266. doi: 10.1111/trf.14435. Epub 2017 Dec 15.

12.

Mechanisms of Toxicity and Modulation of Hemoglobin-Based Oxygen Carriers (HBOCs).

Alayash AI.

Shock. 2017 Nov 3. doi: 10.1097/SHK.0000000000001044. [Epub ahead of print]

13.

Engineering oxidative stability in human hemoglobin based on the Hb providence (βK82D) mutation and genetic cross-linking.

Strader MB, Bangle R, Parker Siburt CJ, Varnado CL, Soman J, Benitez Cardenas AS, Samuel PP, Singleton EW, Crumbliss AL, Olson JS, Alayash AI.

Biochem J. 2017 Dec 11;474(24):4171-4192. doi: 10.1042/BCJ20170491.

PMID:
29070524
14.

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.

Kassa T, Strader MB, Nakagawa A, Zapol WM, Alayash AI.

Metallomics. 2017 Sep 20;9(9):1260-1270. doi: 10.1039/c7mt00104e.

15.

Oxidative pathways in the sickle cell and beyond.

Alayash AI.

Blood Cells Mol Dis. 2018 May;70:78-86. doi: 10.1016/j.bcmd.2017.05.009. Epub 2017 May 20. Review.

16.

Redox Chemistry of Hemoglobin-Associated Disorders.

Bulow L, Alayash AI.

Antioxid Redox Signal. 2017 May 10;26(14):745-747. doi: 10.1089/ars.2016.6948.

PMID:
28398821
17.

Determination of extinction coefficients of human hemoglobin in various redox states.

Meng F, Alayash AI.

Anal Biochem. 2017 Mar 15;521:11-19. doi: 10.1016/j.ab.2017.01.002. Epub 2017 Jan 6.

18.

Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Alayash AI.

Biomolecules. 2017 Jan 4;7(1). pii: E2. doi: 10.3390/biom7010002. Review.

19.

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.

Shah SN, Gelderman MP, Lewis EM, Farrel J, Wood F, Strader MB, Alayash AI, Vostal JG.

PLoS One. 2016 Dec 13;11(12):e0166657. doi: 10.1371/journal.pone.0166657. eCollection 2016.

20.

Exploring Oxidative Reactions in Hemoglobin Variants Using Mass Spectrometry: Lessons for Engineering Oxidatively Stable Oxygen Therapeutics.

Strader MB, Alayash AI.

Antioxid Redox Signal. 2017 May 10;26(14):777-793. doi: 10.1089/ars.2016.6805. Epub 2016 Oct 20. Review.

21.

Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1.

Kassa T, Jana S, Meng F, Alayash AI.

FEBS Open Bio. 2016 Aug 8;6(9):876-84. doi: 10.1002/2211-5463.12103. eCollection 2016 Sep.

22.

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.

Shi PA, Choi E, Chintagari NR, Nguyen J, Guo X, Yazdanbakhsh K, Mohandas N, Alayash AI, Manci EA, Belcher JD, Vercellotti GM.

Br J Haematol. 2016 Nov;175(4):714-723. doi: 10.1111/bjh.14280. Epub 2016 Aug 10.

23.

Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia.

Strader MB, Kassa T, Meng F, Wood FB, Hirsch RE, Friedman JM, Alayash AI.

Redox Biol. 2016 Aug;8:363-74. doi: 10.1016/j.redox.2016.03.004. Epub 2016 Mar 10.

24.

Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.

Chintagari NR, Jana S, Alayash AI.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):288-98. doi: 10.1165/rcmb.2015-0197OC.

25.

Memorial - Dr. Joseph C. Fratantoni.

Alayash AI.

Artif Cells Nanomed Biotechnol. 2016 Jun;44(4):1049. doi: 10.3109/21691401.2016.1154278. Epub 2016 Mar 7. No abstract available.

PMID:
26950293
26.

Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.

Rutardottir S, Karnaukhova E, Nantasenamat C, Songtawee N, Prachayasittikul V, Rajabi M, Rosenlöf LW, Alayash AI, Åkerström B.

Biochim Biophys Acta. 2016 Jan;1864(1):29-41. doi: 10.1016/j.bbapap.2015.10.002. Epub 2015 Oct 21.

PMID:
26497278
27.

Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10).

Kassa T, Jana S, Strader MB, Meng F, Jia Y, Wilson MT, Alayash AI.

J Biol Chem. 2015 Nov 13;290(46):27939-58. doi: 10.1074/jbc.M115.651257. Epub 2015 Sep 22.

28.

Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.

Ratanasopa K, Strader MB, Alayash AI, Bulow L.

Front Physiol. 2015 Feb 20;6:39. doi: 10.3389/fphys.2015.00039. eCollection 2015.

29.

Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.

Chintagari NR, Nguyen J, Belcher JD, Vercellotti GM, Alayash AI.

Blood Cells Mol Dis. 2015 Mar;54(3):302-6. doi: 10.1016/j.bcmd.2014.12.001. Epub 2014 Dec 22.

30.

Characterization of heme binding to recombinant α1-microglobulin.

Karnaukhova E, Rutardottir S, Rajabi M, Wester Rosenlöf L, Alayash AI, Åkerström B.

Front Physiol. 2014 Dec 4;5:465. doi: 10.3389/fphys.2014.00465. eCollection 2014.

31.

Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin.

Strader MB, Hicks WA, Kassa T, Singleton E, Soman J, Olson JS, Weiss MJ, Mollan TL, Wilson MT, Alayash AI.

J Biol Chem. 2014 Aug 8;289(32):22342-57. doi: 10.1074/jbc.M114.568980. Epub 2014 Jun 17.

32.

Blood substitutes: why haven't we been more successful?

Alayash AI.

Trends Biotechnol. 2014 Apr;32(4):177-85. doi: 10.1016/j.tibtech.2014.02.006. Epub 2014 Mar 12. Review.

33.

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.

Mollan TL, Jia Y, Banerjee S, Wu G, Kreulen RT, Tsai AL, Olson JS, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2014 Apr;69:265-77. doi: 10.1016/j.freeradbiomed.2014.01.030. Epub 2014 Jan 30.

34.

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

Belcher JD, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash AI, Smith A, Nath KA, Hebbel RP, Vercellotti GM.

Blood. 2014 Jan 16;123(3):377-90. doi: 10.1182/blood-2013-04-495887. Epub 2013 Nov 25.

35.

Modulating hemoglobin nitrite reductase activity through allostery: a mathematical model.

Rong Z, Alayash AI, Wilson MT, Cooper CE.

Nitric Oxide. 2013 Nov 30;35:193-8. doi: 10.1016/j.niox.2013.10.007. Epub 2013 Oct 28.

PMID:
24177061
36.

Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions.

Jia Y, Wood F, Buehler PW, Alayash AI.

PLoS One. 2013;8(3):e59841. doi: 10.1371/journal.pone.0059841. Epub 2013 Mar 29.

37.

Redox reactions of hemoglobin: mechanisms of toxicity and control.

Mollan TL, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2251-3. doi: 10.1089/ars.2013.5195. Epub 2013 Feb 28.

38.

α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.

Mollan TL, Banerjee S, Wu G, Parker Siburt CJ, Tsai AL, Olson JS, Weiss MJ, Crumbliss AL, Alayash AI.

J Biol Chem. 2013 Feb 8;288(6):4288-98. doi: 10.1074/jbc.M112.412064. Epub 2012 Dec 21.

39.

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM.

Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Review.

40.

Molecular controls of the oxygenation and redox reactions of hemoglobin.

Bonaventura C, Henkens R, Alayash AI, Banerjee S, Crumbliss AL.

Antioxid Redox Signal. 2013 Jun 10;18(17):2298-313. doi: 10.1089/ars.2012.4947. Epub 2013 Jan 21. Review.

41.

Haptoglobin: the hemoglobin detoxifier in plasma.

Alayash AI, Andersen CB, Moestrup SK, Bülow L.

Trends Biotechnol. 2013 Jan;31(1):2-3. doi: 10.1016/j.tibtech.2012.10.003. Epub 2012 Nov 7.

PMID:
23140673
42.

Heme binding to human alpha-1 proteinase inhibitor.

Karnaukhova E, Krupnikova SS, Rajabi M, Alayash AI.

Biochim Biophys Acta. 2012 Dec;1820(12):2020-9. doi: 10.1016/j.bbagen.2012.09.012. Epub 2012 Sep 20.

PMID:
23000493
43.

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions.

Banerjee S, Jia Y, Siburt CJ, Abraham B, Wood F, Bonaventura C, Henkens R, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2012 Sep 15;53(6):1317-26. doi: 10.1016/j.freeradbiomed.2012.07.023. Epub 2012 Jul 27.

PMID:
22841869
44.

Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)).

Mollan TL, Abraham B, Strader MB, Jia Y, Lozier JN, Olson JS, Alayash AI.

Protein Sci. 2012 Oct;21(10):1444-55. doi: 10.1002/pro.2130. Epub 2012 Aug 21.

45.

Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547. Epub 2012 Aug 6.

46.

Enhanced nitrite reductase activity associated with the haptoglobin complexed hemoglobin dimer: functional and antioxidative implications.

Roche CJ, Dantsker D, Alayash AI, Friedman JM.

Nitric Oxide. 2012 Jun 30;27(1):32-9. doi: 10.1016/j.niox.2012.04.002. Epub 2012 Apr 18.

47.

Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration.

Reiter CE, Alayash AI.

FEBS Open Bio. 2012 May 24;2:113-8. doi: 10.1016/j.fob.2012.05.003. Print 2012.

48.

Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry.

Tran DT, Banerjee S, Alayash AI, Crumbliss AL, Fitzgerald MC.

Anal Chem. 2012 Feb 7;84(3):1653-60. doi: 10.1021/ac202927p. Epub 2012 Jan 18.

49.

Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney.

Manalo DJ, Baek JH, Buehler PW, Struble E, Abraham B, Alayash AI.

Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):421-6. doi: 10.1016/j.bbrc.2011.11.085. Epub 2011 Nov 25.

PMID:
22138393
50.

Isolated Hb Providence β82Asn and β82Asp fractions are more stable than native HbA(0) under oxidative stress conditions.

Abraham B, Hicks W, Jia Y, Baek JH, Miller JL, Alayash AI.

Biochemistry. 2011 Nov 15;50(45):9752-66. doi: 10.1021/bi200876e. Epub 2011 Oct 21.

PMID:
21977904

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