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Items: 1 to 50 of 283

1.

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.

Duman RS, Aghajanian GK, Sanacora G, Krystal JH.

Nat Med. 2016 Mar;22(3):238-49. doi: 10.1038/nm.4050.

2.

Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions.

Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8106-11. doi: 10.1073/pnas.1414728112. Epub 2015 Jun 8.

3.

Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses.

Liu RJ, Ota KT, Dutheil S, Duman RS, Aghajanian GK.

Neuropsychopharmacology. 2015 Aug;40(9):2066-75. doi: 10.1038/npp.2015.70. Epub 2015 Mar 11.

4.

REDD1 is essential for stress-induced synaptic loss and depressive behavior.

Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS.

Nat Med. 2014 May;20(5):531-5. doi: 10.1038/nm.3513. Epub 2014 Apr 13.

5.

Medial prefrontal D1 dopamine neurons control food intake.

Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ.

Nat Neurosci. 2014 Feb;17(2):248-53. doi: 10.1038/nn.3625. Epub 2014 Jan 19.

6.

Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β.

Duman RS, Aghajanian GK.

Neuropsychopharmacology. 2014 Jan;39(1):233. doi: 10.1038/npp.2013.217. No abstract available.

7.

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine.

Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK.

Neuropsychopharmacology. 2013 Oct;38(11):2268-77. doi: 10.1038/npp.2013.128. Epub 2013 May 17.

8.

Synaptic dysfunction in depression: potential therapeutic targets.

Duman RS, Aghajanian GK.

Science. 2012 Oct 5;338(6103):68-72. doi: 10.1126/science.1222939. Review.

9.

Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex.

Liu RJ, Lee FS, Li XY, Bambico F, Duman RS, Aghajanian GK.

Biol Psychiatry. 2012 Jun 1;71(11):996-1005. doi: 10.1016/j.biopsych.2011.09.030. Epub 2011 Oct 29.

10.

Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.

Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ.

J Neurosci. 2010 Jun 16;30(24):8263-73. doi: 10.1523/JNEUROSCI.5858-09.2010.

11.

Modeling "psychosis" in vitro by inducing disordered neuronal network activity in cortical brain slices.

Aghajanian GK.

Psychopharmacology (Berl). 2009 Nov;206(4):575-85. doi: 10.1007/s00213-009-1484-9. Epub 2009 Feb 25. Review.

12.

Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy.

Liu RJ, Aghajanian GK.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):359-64. doi: 10.1073/pnas.0706679105. Epub 2008 Jan 2.

13.

Schizophrenia, hypocretin (orexin), and the thalamocortical activating system.

Lambe EK, Liu RJ, Aghajanian GK.

Schizophr Bull. 2007 Nov;33(6):1284-90. Epub 2007 Jul 26. Review.

14.
15.

Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors.

Han MH, Bolaños CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghajanian GK, Nestler EJ.

J Neurosci. 2006 Apr 26;26(17):4624-9.

16.

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK.

J Neurobiol. 2006 Mar;66(4):408-20.

17.

Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors.

Lambe EK, Aghajanian GK.

Neuropsychopharmacology. 2006 Aug;31(8):1682-9. Epub 2005 Nov 2.

18.

Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.

Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK.

J Neurosci. 2005 May 25;25(21):5225-9.

19.
21.

Regulation of RGS proteins by chronic morphine in rat locus coeruleus.

Gold SJ, Han MH, Herman AE, Ni YG, Pudiak CM, Aghajanian GK, Liu RJ, Potts BW, Mumby SM, Nestler EJ.

Eur J Neurosci. 2003 Mar;17(5):971-80.

PMID:
12653973
22.

Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex.

Lambe EK, Picciotto MR, Aghajanian GK.

Neuropsychopharmacology. 2003 Feb;28(2):216-25.

23.
24.

Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus.

Liu R, Ding Y, Aghajanian GK.

Neuropsychopharmacology. 2002 Sep;27(3):329-40.

25.

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R.

J Neurosci. 2002 May 15;22(10):4153-62.

26.

Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus.

van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB.

J Physiol. 2002 May 15;541(Pt 1):169-85.

28.

Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.

Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, Aghajanian GK, Jaenisch R.

Mol Psychiatry. 2001 Sep;6(5):593-604.

30.

Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat.

Lambe EK, Goldman-Rakic PS, Aghajanian GK.

Cereb Cortex. 2000 Oct;10(10):974-80.

PMID:
11007548
31.

Serotonin model of schizophrenia: emerging role of glutamate mechanisms.

Aghajanian GK, Marek GJ.

Brain Res Brain Res Rev. 2000 Mar;31(2-3):302-12. Review.

PMID:
10719157
32.

Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies.

Abellán MT, Jolas T, Aghajanian GK, Artigas F.

Synapse. 2000 Apr;36(1):21-34.

PMID:
10700023
34.

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK.

J Pharmacol Exp Ther. 2000 Jan;292(1):76-87.

PMID:
10604933
35.

Molecular control of locus coeruleus neurotransmission.

Nestler EJ, Alreja M, Aghajanian GK.

Biol Psychiatry. 1999 Nov 1;46(9):1131-9. Review.

PMID:
10560020
36.

Caveat emptor: researcher beware.

Lieberman JA, Aghajanian GK.

Neuropsychopharmacology. 1999 Oct;21(4):471-3. No abstract available.

37.

Serotonin and hallucinogens.

Aghajanian GK, Marek GJ.

Neuropsychopharmacology. 1999 Aug;21(2 Suppl):16S-23S. Review.

41.

The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis.

Marek GJ, Aghajanian GK.

Biol Psychiatry. 1998 Dec 1;44(11):1118-27. Review.

PMID:
9836015
42.

Indoleamine and the phenethylamine hallucinogens: mechanisms of psychotomimetic action.

Marek GJ, Aghajanian GK.

Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):189-98. Review. No abstract available.

PMID:
9716940
43.

CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence.

Lane-Ladd SB, Pineda J, Boundy VA, Pfeuffer T, Krupinski J, Aghajanian GK, Nestler EJ.

J Neurosci. 1997 Oct 15;17(20):7890-901.

44.

Molecular and cellular basis of addiction.

Nestler EJ, Aghajanian GK.

Science. 1997 Oct 3;278(5335):58-63. Review.

PMID:
9311927
45.

Neurotensin and the serotonergic system.

Jolas T, Aghajanian GK.

Prog Neurobiol. 1997 Aug;52(6):455-68. Review.

PMID:
9316156
46.
47.

5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex.

Vaidya VA, Marek GJ, Aghajanian GK, Duman RS.

J Neurosci. 1997 Apr 15;17(8):2785-95.

48.

Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.

Aghajanian GK, Marek GJ.

Neuropharmacology. 1997 Apr-May;36(4-5):589-99.

PMID:
9225284
50.

The role of serotonin in the pathophysiology and treatment of schizophrenia.

Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J.

J Neuropsychiatry Clin Neurosci. 1997 Winter;9(1):1-17. Review.

PMID:
9017523

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