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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2003 2
2004 2
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2008 1
2009 4
2010 3
2011 2
2012 3
2013 5
2014 4
2015 1
2016 5
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2023 4
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71 results

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Page 1
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
Blanc V, Riordan JD, Soleymanjahi S, Nadeau JH, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng IO, Ha Y, Roberts LR, Davidson NO. Blanc V, et al. J Clin Invest. 2021 Jan 4;131(1):e138699. doi: 10.1172/JCI138699. J Clin Invest. 2021. PMID: 33445170 Free PMC article.
The RNA-binding protein Apobec1 complementation factor (A1CF) regulates posttranscriptional ApoB mRNA editing, but the range of RNA targets and the long-term effect of altered A1CF expression on liver function are unknown. Here we studied hepatocyte-specific A1cf
The RNA-binding protein Apobec1 complementation factor (A1CF) regulates posttranscriptional ApoB mRNA editing, but the range of RNA t …
A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis.
Ni D, Yi Q, Liu J, Hu Y, Lv T, Tan G, Liu Y, Xu L, Xia H, Zhou Q, Xie Y. Ni D, et al. Gene. 2020 Mar 10;730:144299. doi: 10.1016/j.gene.2019.144299. Epub 2019 Dec 24. Gene. 2020. PMID: 31881249
Decreased A1CF expression inhibits the proliferation and colony formation of 786-O cells; and further signaling pathway screening demonstrated that A1CF increases ERK activation and DKK1 expression. ...Decreasing of DKK1 expression reduces the phosphorylation of ERK …
Decreased A1CF expression inhibits the proliferation and colony formation of 786-O cells; and further signaling pathway screening dem …
A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/beta-catenin pathway.
Ni D, Liu J, Hu Y, Liu Y, Gu Y, Zhou Q, Xie Y. Ni D, et al. In Vitro Cell Dev Biol Anim. 2019 Apr;55(4):252-259. doi: 10.1007/s11626-019-00335-6. Epub 2019 Mar 1. In Vitro Cell Dev Biol Anim. 2019. PMID: 30825095
Here, we explored the regulatory function of A1CF in Wilms tumor-derived cells. Quantitative real-time PCR was performed to detect the mRNA level of A1CF, Axin2, beta-Catenin, CCND1 or NKD1 in A1CF-depleted or A1CF-overexpression G401 cells. ...Our stu …
Here, we explored the regulatory function of A1CF in Wilms tumor-derived cells. Quantitative real-time PCR was performed to detect th …
Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice.
Hirose N, Blanchet G, Yamauchi Y, Snow AC, Friedman R, Khoo CY, Lary CW, Ward MA, Nadeau JH. Hirose N, et al. Sci Rep. 2022 Aug 10;12(1):13599. doi: 10.1038/s41598-022-17948-9. Sci Rep. 2022. PMID: 35948620 Free PMC article.
To address this question, we used in vitro fertilization (IVF) with a mutant and wild-type allele of the A1cf (APOBEC1 complementation factor) gene in mice that are otherwise genetically identical. ...We propose that failure to sequester mRNA targets in A1cf mutant …
To address this question, we used in vitro fertilization (IVF) with a mutant and wild-type allele of the A1cf (APOBEC1 complementatio …
APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.
Snyder EM, McCarty C, Mehalow A, Svenson KL, Murray SA, Korstanje R, Braun RE. Snyder EM, et al. RNA. 2017 Apr;23(4):457-465. doi: 10.1261/rna.058818.116. Epub 2017 Jan 9. RNA. 2017. PMID: 28069890 Free PMC article.
This work aimed to address the function of A1CF in adult mouse tissues using a conditional A1cf allele. Unexpectedly, A1cf-null mice were viable and fertile with modest defects in hematopoietic, immune, and metabolic parameters. ...However, molecular analysis …
This work aimed to address the function of A1CF in adult mouse tissues using a conditional A1cf allele. Unexpectedly, A1cf
Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.
Blanc V, Xie Y, Kennedy S, Riordan JD, Rubin DC, Madison BB, Mills JC, Nadeau JH, Davidson NO. Blanc V, et al. RNA. 2019 Jan;25(1):70-81. doi: 10.1261/rna.068395.118. Epub 2018 Oct 11. RNA. 2019. PMID: 30309881 Free PMC article.
Here we examined the role of A1CF and RBM47 in adult mouse liver and intestine, following deletion of either one or both gene products and also following forced (liver or intestinal) transgenic A1CF expression. There were minimal changes in hepatic and intestinal ap …
Here we examined the role of A1CF and RBM47 in adult mouse liver and intestine, following deletion of either one or both gene product …
The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing.
Nikolaou KC, Vatandaslar H, Meyer C, Schmid MW, Tuschl T, Stoffel M. Nikolaou KC, et al. Cell Rep. 2019 Oct 8;29(2):283-300.e8. doi: 10.1016/j.celrep.2019.08.100. Cell Rep. 2019. PMID: 31597092 Free article.
Here, we report a major role for the hormone-sensitive RNA-binding protein (RBP) APOBEC1 complementation factor (A1CF) in the generation of hepatocyte-specific and alternatively spliced transcripts. Among these transcripts are isoforms for the dominant and high-affinity fr …
Here, we report a major role for the hormone-sensitive RNA-binding protein (RBP) APOBEC1 complementation factor (A1CF) in the generat …
Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.
Kawaguchi M, Nakayama A, Aoyagi Y, Nakamura T, Shimizu S, Kawamura Y, Takao M, Tamura T, Hishida A, Nagayoshi M, Nagase M, Ooyama K, Ooyama H, Shinomiya N, Matsuo H. Kawaguchi M, et al. Hum Cell. 2021 Mar;34(2):293-299. doi: 10.1007/s13577-021-00485-4. Epub 2021 Jan 31. Hum Cell. 2021. PMID: 33517564 Free PMC article.
Replication studies revealed both SNPs to be significantly associated with gout (P = 0.0366, odds ratio [OR] with 95% confidence interval [CI]: 1.30 [1.02-1.68] for rs10821905 of A1CF, P = 6.49 10(-3), OR with 95% CI: 1.29 [1.07-1.55] for rs1178977 of BAZ1B). Meta-analysis …
Replication studies revealed both SNPs to be significantly associated with gout (P = 0.0366, odds ratio [OR] with 95% confidence interval [C …
Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells.
Song Y, Shao L, Xue Y, Ruan X, Liu X, Yang C, Zheng J, Shen S, Chen J, Li Z, Liu Y. Song Y, et al. J Exp Clin Cancer Res. 2019 Jun 11;38(1):248. doi: 10.1186/s13046-019-1200-5. J Exp Clin Cancer Res. 2019. PMID: 31186064 Free PMC article.
Moreover, luciferase reporter, RIP and ChIP assays were used to investigate the interactions among A1CF, FAM224A, miR-590-3p, ZNF143, ASAP3 and MYB. Finally, the xenograft tumor growth assay further ascertained the biological roles of A1CF, FAM224A and miR-590-3p in …
Moreover, luciferase reporter, RIP and ChIP assays were used to investigate the interactions among A1CF, FAM224A, miR-590-3p, ZNF143, …
Interactomics Analyses of Wild-Type and Mutant A1CF Reveal Diverged Functions in Regulating Cellular Lipid Metabolism.
Xu YX, Stanclift C, Nagai TH, Yu H, Vellarikkal SK, Deik A, Bullock K, Schenone M, Cowan C, Clish CB, Carr S, Kathiresan S. Xu YX, et al. J Proteome Res. 2020 Oct 2;19(10):3968-3980. doi: 10.1021/acs.jproteome.0c00235. Epub 2020 Sep 2. J Proteome Res. 2020. PMID: 32786677
Here, we used multiomics approaches to interrogate the functional difference between the WT and mutant A1CF. Using metabolomics analyses, we captured the cellular lipid metabolite changes induced by transient expression of the proteins, confirming that the mutant A1CF
Here, we used multiomics approaches to interrogate the functional difference between the WT and mutant A1CF. Using metabolomics analy …
71 results