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Best matches for Aínsa JA[au]:

Antituberculosis drugs: reducing efflux=increasing activity. Rodrigues L et al. Drug Discov Today. (2017)

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. Mori G et al. Tuberculosis (Edinb). (2018)

How can nanoparticles contribute to antituberculosis therapy? Costa-Gouveia J et al. Drug Discov Today. (2017)

Search results

Items: 46

1.

Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA).

Hibbitts A, Lucía A, Serrano-Sevilla I, De Matteis L, McArthur M, de la Fuente JM, Aínsa JA, Navarro F.

PLoS One. 2019 Sep 3;14(9):e0220684. doi: 10.1371/journal.pone.0220684. eCollection 2019.

2.

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice.

Salillas S, Alías M, Michel V, Mahía A, Lucía A, Rodrigues L, Bueno J, Galano-Frutos JJ, De Reuse H, Velázquez-Campoy A, Carrodeguas JA, Sostres C, Castillo J, Aínsa JA, Díaz-de-Villegas MD, Lanas Á, Touati E, Sancho J.

J Med Chem. 2019 Jul 11;62(13):6102-6115. doi: 10.1021/acs.jmedchem.9b00355. Epub 2019 Jun 21.

PMID:
31244111
3.

Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles.

Sanz-García F, Anoz-Carbonell E, Pérez-Herrán E, Martín C, Lucía A, Rodrigues L, Aínsa JA.

Front Microbiol. 2019 Jan 30;10:46. doi: 10.3389/fmicb.2019.00046. eCollection 2019.

4.

Matryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis.

Andreu V, Larrea A, Rodriguez-Fernandez P, Alfaro S, Gracia B, Lucía A, Usón L, Gomez AC, Mendoza G, Lacoma A, Dominguez J, Prat C, Sebastian V, Ainsa JA, Arruebo M.

Nanomedicine (Lond). 2019 Mar;14(6):707-726. doi: 10.2217/nnm-2018-0258. Epub 2019 Feb 8.

PMID:
30734643
5.

Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline.

Soria-Carrera H, Lucía A, De Matteis L, Aínsa JA, de la Fuente JM, Martín-Rapún R.

Macromol Biosci. 2019 Apr;19(4):e1800397. doi: 10.1002/mabi.201800397. Epub 2019 Jan 15.

PMID:
30645022
6.

Synthesis and biological activity of dehydrophos derivatives.

Jiménez-Andreu MM, Lucía Quintana A, Aínsa JA, Sayago FJ, Cativiela C.

Org Biomol Chem. 2019 Jan 31;17(5):1097-1112. doi: 10.1039/c8ob03079k.

PMID:
30633297
7.

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Jha RK, Kumar P, Freundlich JS, Brodin P, Aínsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S.

Tuberculosis (Edinb). 2018 Sep;112:98-109. doi: 10.1016/j.tube.2018.08.004. Epub 2018 Aug 11.

PMID:
30205975
8.

Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis.

García MT, Carreño D, Tirado-Vélez JM, Ferrándiz MJ, Rodrigues L, Gracia B, Amblar M, Ainsa JA, de la Campa AG.

Front Microbiol. 2018 Jul 24;9:1659. doi: 10.3389/fmicb.2018.01659. eCollection 2018.

9.

Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis.

Aguilar-Pérez C, Gracia B, Rodrigues L, Vitoria A, Cebrián R, Deboosère N, Song OR, Brodin P, Maqueda M, Aínsa JA.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00359-18. doi: 10.1128/AAC.00359-18. Print 2018 Sep.

10.

Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs.

Glaus F, Dedić D, Tare P, Nagaraja V, Rodrigues L, Aínsa JA, Kunze J, Schneider G, Hartkoorn RC, Cole ST, Altmann KH.

J Org Chem. 2018 Jul 6;83(13):7150-7172. doi: 10.1021/acs.joc.8b00193. Epub 2018 Mar 29.

PMID:
29542926
11.

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Aínsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S.

J Med Chem. 2018 Apr 12;61(7):2753-2775. doi: 10.1021/acs.jmedchem.7b01570. Epub 2018 Mar 15.

PMID:
29510037
12.

Discovery of antimicrobial compounds targeting bacterial type FAD synthetases.

Sebastián M, Anoz-Carbonell E, Gracia B, Cossio P, Aínsa JA, Lans I, Medina M.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):241-254. doi: 10.1080/14756366.2017.1411910.

PMID:
29258359
13.

Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem.

Huang W, Briffotaux J, Wang X, Liu L, Hao P, Cimino M, Buchieri MV, Namouchi A, Ainsa JA, Gicquel B.

Tuberculosis (Edinb). 2017 Dec;107:111-118. doi: 10.1016/j.tube.2017.09.001. Epub 2017 Sep 6.

PMID:
29050757
14.

How can nanoparticles contribute to antituberculosis therapy?

Costa-Gouveia J, Aínsa JA, Brodin P, Lucía A.

Drug Discov Today. 2017 Mar;22(3):600-607. doi: 10.1016/j.drudis.2017.01.011. Epub 2017 Jan 27. Review.

PMID:
28137645
15.

Antituberculosis drugs: reducing efflux=increasing activity.

Rodrigues L, Parish T, Balganesh M, Ainsa JA.

Drug Discov Today. 2017 Mar;22(3):592-599. doi: 10.1016/j.drudis.2017.01.002. Epub 2017 Jan 13. Review.

PMID:
28089787
16.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

17.

Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development.

Bailo R, Bhatt A, Aínsa JA.

Biochem Pharmacol. 2015 Aug 1;96(3):159-67. doi: 10.1016/j.bcp.2015.05.001. Epub 2015 May 16. Review.

PMID:
25986884
18.

Measuring efflux and permeability in mycobacteria.

Rodrigues L, Viveiros M, Aínsa JA.

Methods Mol Biol. 2015;1285:227-39. doi: 10.1007/978-1-4939-2450-9_13.

PMID:
25779319
19.

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Lee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, Ainsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, Böttger EC, Lenaerts AJ.

Nat Med. 2014 Feb;20(2):152-158. doi: 10.1038/nm.3458. Epub 2014 Jan 26.

20.

Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype.

Villellas C, Aristimuño L, Vitoria MA, Prat C, Blanco S, García de Viedma D, Domínguez J, Samper S, Aínsa JA.

J Clin Microbiol. 2013 Jul;51(7):2124-30. doi: 10.1128/JCM.01944-12. Epub 2013 Apr 24.

21.

Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages.

Luo X, Pires D, Aínsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJ.

J Ethnopharmacol. 2013 Mar 7;146(1):417-22. doi: 10.1016/j.jep.2013.01.013. Epub 2013 Jan 18.

PMID:
23337743
22.

Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis.

Rodrigues L, Villellas C, Bailo R, Viveiros M, Aínsa JA.

Antimicrob Agents Chemother. 2013 Feb;57(2):751-7. doi: 10.1128/AAC.01482-12. Epub 2012 Nov 19.

23.

Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages.

Eitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, Aínsa JA, Hansen EJ, Gumbo T, van Oers NS.

Appl Environ Microbiol. 2012 Oct;78(19):6829-37. doi: 10.1128/AEM.01674-12. Epub 2012 Jul 20.

24.

Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.

Ramón-García S, Mick V, Dainese E, Martín C, Thompson CJ, De Rossi E, Manganelli R, Aínsa JA.

Antimicrob Agents Chemother. 2012 Apr;56(4):2074-83. doi: 10.1128/AAC.05946-11. Epub 2012 Jan 9.

25.

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.

Tizón L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, González-Bello C.

J Med Chem. 2011 Sep 8;54(17):6063-84. doi: 10.1021/jm2006063. Epub 2011 Aug 3.

PMID:
21780742
26.

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique.

Luo X, Pires D, Aínsa JA, Gracia B, Mulhovo S, Duarte A, Anes E, Ferreira MJ.

J Ethnopharmacol. 2011 Sep 1;137(1):114-20. doi: 10.1016/j.jep.2011.04.062. Epub 2011 May 5.

PMID:
21571059
27.

Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors.

Rodrigues L, Aínsa JA, Amaral L, Viveiros M.

Recent Pat Antiinfect Drug Discov. 2011 May;6(2):118-27. Review.

PMID:
21517739
28.

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.

Familiar O, Munier-Lehmann H, Aínsa JA, Camarasa MJ, Pérez-Pérez MJ.

Eur J Med Chem. 2010 Dec;45(12):5910-8. doi: 10.1016/j.ejmech.2010.09.056. Epub 2010 Oct 15.

PMID:
20951473
29.

The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2).

Aínsa JA, Bird N, Ryding NJ, Findlay KC, Chater KF.

Antonie Van Leeuwenhoek. 2010 Aug;98(2):225-36. doi: 10.1007/s10482-010-9443-3. Epub 2010 Apr 20.

PMID:
20405209
30.

Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth.

Ramón-García S, Martín C, Thompson CJ, Aínsa JA.

Antimicrob Agents Chemother. 2009 Sep;53(9):3675-82. doi: 10.1128/AAC.00550-09. Epub 2009 Jun 29.

31.

Transcriptional analysis of and resistance level conferred by the aminoglycoside acetyltransferase gene aac(2')-Id from Mycobacterium smegmatis.

Mick V, Rebollo MJ, Lucía A, García MJ, Martín C, Aínsa JA.

J Antimicrob Chemother. 2008 Jan;61(1):39-45. Epub 2007 Nov 20.

PMID:
18032424
32.

Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG.

Ramón-García S, Martín C, De Rossi E, Aínsa JA.

J Antimicrob Chemother. 2007 Mar;59(3):544-7. Epub 2007 Jan 22.

PMID:
17242035
33.

Novel streptomycin resistance gene from Mycobacterium fortuitum.

Ramón-García S, Otal I, Martín C, Gómez-Lus R, Aínsa JA.

Antimicrob Agents Chemother. 2006 Nov;50(11):3920-2. Epub 2006 Sep 5.

34.

Role of mycobacterial efflux transporters in drug resistance: an unresolved question.

De Rossi E, Aínsa JA, Riccardi G.

FEMS Microbiol Rev. 2006 Jan;30(1):36-52. Review.

35.

Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum.

Ramón-García S, Martín C, Aínsa JA, De Rossi E.

J Antimicrob Chemother. 2006 Feb;57(2):252-9. Epub 2005 Dec 22.

PMID:
16373429
36.

The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.

De Rossi E, Arrigo P, Bellinzoni M, Silva PA, Martín C, Aínsa JA, Guglierame P, Riccardi G.

Mol Med. 2002 Nov;8(11):714-24.

37.

Molecular approaches to tuberculosis.

Aínsa JA, Martín C, Gicquel B.

Mol Microbiol. 2001 Oct;42(2):561-70. No abstract available.

38.

Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.

Silva PE, Bigi F, Santangelo MP, Romano MI, Martín C, Cataldi A, Aínsa JA.

Antimicrob Agents Chemother. 2001 Mar;45(3):800-4.

39.

WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2).

Aínsa JA, Ryding NJ, Hartley N, Findlay KC, Bruton CJ, Chater KF.

J Bacteriol. 2000 Oct;182(19):5470-8.

40.
41.
42.

katGI and katGII encode two different catalases-peroxidases in Mycobacterium fortuitum.

Menéndez MC, Ainsa JA, Martín C, García MJ.

J Bacteriol. 1997 Nov;179(22):6880-6.

43.

Isolation by genetic labeling of a new mycobacterial plasmid, pJAZ38, from Mycobacterium fortuitum.

Gavigan JA, Aínsa JA, Pérez E, Otal I, Martín C.

J Bacteriol. 1997 Jul;179(13):4115-22.

46.

Characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase gene from Mycobacterium fortuitum.

Aínsa JA, Martin C, Gicquel B, Gomez-Lus R.

Antimicrob Agents Chemother. 1996 Oct;40(10):2350-5.

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