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Fertil Steril. 1999 Feb;71(2):323-7.

Effect of troglitazone on endocrine and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome.

Author information

1
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.

Abstract

OBJECTIVE:

To investigate the effect of troglitazone, a new antidiabetic agent that improves insulin resistance, on endocrine, metabolic, and ovulatory performance in women with insulin resistance-related polycystic ovary syndrome (PCOS).

DESIGN:

Prospective clinical study.

SETTING:

Infertility outpatient clinic, Niigata University Hospital, Niigata, Japan.

PATIENT(S):

Thirteen women with PCOS and insulin resistance.

INTERVENTION(S):

Troglitazone (400 mg/d) was administered for 12 weeks.

MAIN OUTCOME MEASURE(S):

Insulin and other hormone (gonadotropins, androgens) levels; various parameters relating to glucose and lipid metabolism before, during, and after troglitazone administration; and ovulation rate.

RESULT(S):

The mean (+/-SD) fasting insulin concentration was significantly reduced, from 18.3+/-8.9 to 10.5+/-7.1 microU/mL. The LH level was reduced from 9.7+/-3.4 to 4.8+/-3.9 mIU/mL and the testosterone level was reduced from 0.9+/-0.5 to 0.5+/-0.3 ng/mL in accordance. Atherosclerotic lipid levels also were normalized. Before troglitazone administration, the ovulation rate during clomiphene citrate therapy was 34.9% per cycle (15/43). This increased significantly to 72.7% (8/11) during troglitazone coadministration. Further, an ovulation rate of 42.3% (11/26) was achieved with troglitazone alone.

CONCLUSION(S):

In women with PCOS and insulin resistance, the reduction of hyperinsulinemia that is produced by troglitazone improves the hyperandrogenism that characterizes PCOS, restoring ovulation.

PMID:
9988406
DOI:
10.1016/s0015-0282(98)00454-3
[Indexed for MEDLINE]

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