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Rev Assoc Med Bras (1992). 1998 Apr-Jun;44(2):94-8.

Ovarian activity before and after gonadal suppression by GnRH-a in patients with polycystic ovary syndrome, hyperandrogenism, hyperinsulinism and acanthosis nigricans.

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1
Department of Gynecology, Universidade Federal de São Paulo, Brazil.

Abstract

OBJECTIVE:

To investigate the ovarian activity before and after gonadal suppression with GnRH-analog in patients with PCO, hyperandrogenism, hyperinsulinism and acanthosis nigricans.

DESIGN:

Controlled clinical study.

SETTING:

Tertiary academic medical center.

PATIENTS:

Six patients with clinical findings of PCO, hirsutism and acanthosis nigricans.

INTERVENTIONS:

Morning blood samples in the follicular phase to determine the steroid levels, glucose and insulin curve, comparing to a control group. Administration for 2 consecutive months of a GnRH-analog, comparing, in the study group, the free testosterone levels before and after ovarian suppression.

MAIN OUTCOME MEASURE:

Determination of insulin levels in PCO, hirsutism and acanthotic patients and the free-testosterone levels before and after gonadal suppression.

RESULTS:

Insulin levels were significantly higher in the study group when compared to normal women during the glycemic test. We also found a significant decrease in the free-testosterone levels after 2 months of gonadal suppression with GnRH-analog when compared to the initial time.

CONCLUSIONS:

Patients with PCO, hirsutism and acanthosis nigricans present high levels of insulin, suggesting an ovarian hyperesponsiveness, which is not sustained when gonadotrophic blockage was achieved.

PMID:
9699325
[Indexed for MEDLINE]

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