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Nat Struct Biol. 1997 Sep;4(9):699-703.

Crystal structure of RhoA-GDP and its functional implications.

Abstract

RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 A resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.

PMID:
9302995
[Indexed for MEDLINE]

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