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Zhonghua Yi Xue Za Zhi. 1996 Jul;76(7):519-23.

[Obesity may have more pronounced effect on the occurrence of insulin resistance than hypertension].

[Article in Chinese]

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Department of Cardiology, First Affiliated Hospital, Fujian Medical College, Fuzhou.



To compare the extent of insulin resistance in hypertensive and in obesity patients and verify their role on the occurrence of insulin resistance.


Insulin sensitivity was assessed by using euglycemic insulin clamp technique (EICT) in normal subjects (NS, n = 36), obesity (n = 23), hypertensive non-obesity patients (HT+nonobesity, n = 51) and hypertensive and obesity patients (HT+obesity, n = 54) Glucose metabolism ratio (M) served as an index of insulin sensitivity.


The height sequence of M value was: NS > HT+nonobesity > obesity > HT+obesity (ie, 9.2 +/- 1.0 > 7.6 +/- 2.0 > 6.7 +/- 1.5 > 5.2 +/- 1.8, P < 0.05). The incidence rate of decreased insulin sensitivity among the four groups was: HT+obesity > obesity > HT+nonobesity > NS (87.0%, 69.6%, 41.1% and 2.8%, P < 0.05). After adjusting for age, sex and BMI, M value was greater in normotensives (n = 59) than in hypertension patients (n = 105) (8.0 versus 6.6, P < 0.01). Multivariates analysis showed that BMI and SBP are the two most important determinants for M value, but the effect of 1 kg/m2 BMI is equivalent to that of 20 mmHg SBP.


Decreased insulin sensitivity may be the common linkage between obesity and hypertension. Obesity may have more pronounced effect on insulin sensitivity than hypertension.

[Indexed for MEDLINE]

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