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Science. 1996 Aug 30;273(5279):1239-41.

A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis.

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Department of Botany, University of Toronto, 25 Willcocks Street, Toronto, Canada, M5S 3B2.


The hormone abscisic acid (ABA) modulates a variety of developmental processes and responses to environmental stress in higher plants. A collection of mutations, designated era, in Arabidopsis thaliana that confer an enhanced response to exogenous ABA includes mutations in the Era1 gene, which encodes the beta subunit of a protein farnesyl transferase. In yeast and mammalian systems, farnesyl transferases modify several signal transduction proteins for membrane localization. The era1 mutants suggest that a negative regulator of ABA sensitivity must be acted on by a farnesyl transferase to function.

[Indexed for MEDLINE]

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