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Obstet Gynecol. 1993 May;81(5 ( Pt 2)):810-1.

Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes.

Author information

1
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.

Abstract

BACKGROUND:

Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy.

CASE:

A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery.

CONCLUSION:

This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.

PMID:
8469481
[Indexed for MEDLINE]

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