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Cancer Genet Cytogenet. 1993 Sep;69(2):113-7.

Detection of the PML/RAR alpha fusion gene in acute promyelocytic leukemia with a complex translocation involving chromosomes 15, 17, and 18.

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1
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

Abstract

We report a case with typical clinical features of acute promyelocytic leukemia (APL) carrying an atypical chromosomal aberration involving chromosomes 15, 17, and 18. Molecular analysis using Southern blot hybridization and reverse transcriptase-polymerase chain reaction (RT-PCR) proved the creation of the PML/RAR alpha fusion gene in this case. These findings support the notion that this fusion is of crucial importance to leukemogenesis of APL.

PMID:
8402546
[Indexed for MEDLINE]

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