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Rev Med Chil. 1994 Apr;122(4):441-7.

[Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman].

[Article in Spanish]

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Unidad de Endocrinología, Facultad de Medicina (Campus Occidente), Hospital San Juan de Dios.


We report a woman with insulin resistance associated with hyperandrogenism and acanthosis nigricans (HAIR-AN syndrome) treated during 30 days with the prolonged action opioid antagonist Naltrexone. During its administration, decreases in basal blood glucose and serum insulin, insulin and glucose response to a glucose load and plasma testosterone were observed. These findings suggest that opioid activity could play a critical role in the physiopathology of hyperinsulinemia in hyperandrogenic women.

[Indexed for MEDLINE]

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