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FEBS J. 2016 Dec;283(24):4452-4457. doi: 10.1111/febs.13765. Epub 2016 Jun 10.

Correcting the record of structural publications requires joint effort of the community and journal editors.

Author information

1
k.-k. Hofkristallamt, Vista, CA, USA.
2
Department of Genetic Epidemiology, Medical University of Innsbruck, Austria.
3
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD, USA.
4
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
5
School of Chemistry, University of Manchester, UK.
6
Department of Crystallography, Faculty of Chemistry, Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Adam Mickiewicz University, Poznan, Poland.

Abstract

Seriously flawed and even fictional models of biomolecular crystal structures, although rare, still persist in the record of structural repositories and databases. The ensuing problems of database contamination and persistence of publications based on incorrect structure models must be effectively addressed. The burden cannot be simply left to the critical voices who take the effort to contribute dissenting comments that are mostly ignored. The entire structural biology community, and particularly the journal editors who exercise significant power in this respect, must engage in a constructive dialog lest structural biology lose its credibility as an evidence-based empirical science.

KEYWORDS:

X-ray crystal structure models; biomolecular crystallography; database integrity; error correction; structural databases

PMID:
27229767
PMCID:
PMC5124416
DOI:
10.1111/febs.13765
[Indexed for MEDLINE]
Free PMC Article

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