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FEBS Lett. 2014 Aug 25;588(17):2830-6. doi: 10.1016/j.febslet.2014.06.035. Epub 2014 Jun 21.

Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.

Author information

1
Department of Biochemistry, University of Cambridge, Cambridge, UK.
2
Division of Molecular Structure, MRC-National Institute for Medical Research, London, UK.
3
Department of Biochemistry, University of Cambridge, Cambridge, UK; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. Electronic address: tpm22@cam.ac.uk.

Abstract

NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show that this interaction is not mediated by the CARDs of NOD2 and CARD9 as previously suggested, but that NOD2 possesses two interaction sites for CARD9; one in the CARD-NACHT linker and one in the NACHT itself.

KEYWORDS:

Caspase activation and recruitment domain; Crohn’s Disease; Innate immunity; Nucleotide-binding leucine-rich repeat containing receptor; Signal transduction; Stress kinase pathway

PMID:
24960071
PMCID:
PMC4158416
DOI:
10.1016/j.febslet.2014.06.035
[Indexed for MEDLINE]
Free PMC Article

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