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Gynecol Endocrinol. 2014 Jun;30(6):423-7. doi: 10.3109/09513590.2014.895981. Epub 2014 Mar 14.

Interleukin-6 levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome.

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Department of Gynecology and Obstetrics, Faculty of Medicine, Muğla Sıtkı Koçman University , Muğla , Turkey .



The aim of this study was to evaluate serum concentrations of interleukin-6 (IL-6) in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS).


A total of 40 women with PCOS and 40 age-matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject.


Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-6 levels than controls (p < 0.05); however, levels of IL-6 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels.


The data of this study suggested that serum IL-6 levels were found to be higher in women with PCOS as compared to controls; however, IL-6 levels might be dependent on nutritional status but not on PCOS per se. Raised serum IL-6 levels may be related to BMI and serum lipid levels and may be a predictor for cardiometabolic risks.


Interleukin-6; inflammation; polycystic ovary syndrome

[Indexed for MEDLINE]

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