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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):632-7. doi: 10.1107/S1744309112017939. Epub 2012 May 24.

Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.

Author information

1
Molecular Physiology and Biological Physics, University of Virginia, 1340 Jefferson Park Avenue, Jordan Hall, Room 4223, Charlottesville, VA 22908, USA.

Abstract

The crystal structure of a short-chain dehydrogenase/reductase from Bacillus anthracis strain `Ames Ancestor' complexed with NADP has been determined and refined to 1.87 Å resolution. The structure of the enzyme consists of a Rossmann fold composed of seven parallel β-strands sandwiched by three α-helices on each side. An NADP molecule from an endogenous source is bound in the conserved binding pocket in the syn conformation. The loop region responsible for binding another substrate forms two perpendicular short helices connected by a sharp turn.

PMID:
22684058
PMCID:
PMC3370898
DOI:
10.1107/S1744309112017939
[Indexed for MEDLINE]
Free PMC Article

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