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Fertil Steril. 2011 Jul;96(1):246-50. doi: 10.1016/j.fertnstert.2011.04.073. Epub 2011 May 19.

Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome.

Author information

1
Department of Obstetrics and Gynecology, Yuzuncu Yil University, Van, Turkey. recepyildizhan@yahoo.com

Abstract

OBJECTIVE:

To evaluate retinol-binding protein 4 (RBP4), leptin, and asymmetric dimethylarginine (ADMA) levels in young women with polycystic ovary syndrome (PCOS) and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters.

DESIGN:

Clinical study.

SETTING:

University hospital.

PATIENT(S):

Fifty-seven young women with PCOS (obese [n = 27] and nonobese [n = 30]) and 27 age-matched healthy controls.

INTERVENTION(S):

History and physical examination, peripheral venous blood sampling.

MAIN OUTCOME MEASURE(S):

Asymmetric dimethylarginine, RBP4, leptin, LH, FSH, DHEAS, total T, E(2), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride (TG), and homeostasis model assessment insulin resistance index (HOMA-IR).

RESULT(S):

Obese women with PCOS had significantly higher HOMA-IR, DHEAS, leptin, RBP4, and ADMA levels. Leptin levels were significantly increased in nonobese subjects with PCOS. Leptin and ADMA levels were positively correlated with HOMA-IR in PCOS. There was no correlation between RBP4 and HOMA-IR. Leptin, RBP4, and ADMA levels are positively correlated in PCOS.

CONCLUSION(S):

[1] Young obese women with PCOS have increased ADMA, RBP4, and leptin levels, and they are positively correlated with each other. [2] The increased levels of leptin are independent of obesity, and leptin seems to have an association with IR. [3] Levels of RBP4 may not reflect IR in PCOS.

[Indexed for MEDLINE]

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