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Int J Rheum Dis. 2009 Jul;12(2):174-6. doi: 10.1111/j.1756-185X.2009.01402.x.

Type B insulin resistance in a systemic lupus erythematosus patient.

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Department of Medicine, LTM Medical College & LTMG Hospital, Mumbai, India.


In type B insulin resistance and acanthosis nigricans, the insulin resistance is due to the presence of anti-insulin receptor antibody 1. Approximately one-third of patients with these antibodies have an associated illness such as systemic lupus erythematosus (SLE) or Sjögren's syndrome. This report describes a case wherein the patient had presented with uncontrolled diabetes and required > 3000 units of human insulin to control hyperglycemia. She also had features of SLE. There was complete recovery following treatment with steroids.

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