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Int J Obes (Lond). 2010 Feb;34(2):261-5. doi: 10.1038/ijo.2009.198. Epub 2009 Sep 22.

Telomere length and adiposity in a racially diverse sample.

Author information

1
Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

OBJECTIVE:

To evaluate the cross-sectional relationship of anthropometric measures (body mass index (BMI) and visceral fat and the adipokines leptin and adiponectin) with telomere length in a racially diverse sample.

DESIGN:

Cross-sectional study of participants recruited from a health science university.

SUBJECTS:

Participants include 317 men and women aged 40-64 years without diagnosed diabetes, cardiovascular disease (defined as coronary heart disease or stroke/transient ischemic attack) or cancer.

RESULTS:

Study participants were 54.9% female, 58% non-Hispanic white (NHW) and 42% non-Hispanic Black (NHB). Of the sample, 76% were either overweight or obese. Linear regressions showed no association between the anthropometric measures (BMI (kg m(-2)), visceral fat (cm(2)), adiponectin (microg ml(-1)), leptin (ng ml(-1)) or adiponectin to leptin ratio (microg ng(-1))) assessed in a continuous manner and telomere length assay ratio, either for the whole sample or when stratified by race or by gender.

CONCLUSION:

This study finds no linear associations between telomere length and several measures of obesity in a sample of NHB and NHW men and women. Further studies are needed to identify factors that influence telomere length in diverse populations.

PMID:
19773737
DOI:
10.1038/ijo.2009.198
[Indexed for MEDLINE]

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