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Inflamm Allergy Drug Targets. 2009 Sep;8(4):285-91.

Leptin in non-autoimmune inflammation.

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Department of Medicine, University of California Los Angeles, Los Angeles, California 90095-1670, USA.


Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Beh├žet's disease and endometriosis.

[Indexed for MEDLINE]

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