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Int J Mol Sci. 2009 May 26;10(6):2476-86. doi: 10.3390/ijms10062476.

Voltage-dependent anion channel 2 of Arabidopsis thaliana (AtVDAC2) is involved in ABA-mediated early seedling development.

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Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, China; Biotechnology and Genetic Germplasm Institute, Yunnan Academy of Agricultural Sciences, #9 Xueyun Road, Kunming 650223, China.


The voltage-dependent anion channel (VDAC) is the major transport protein in the outer membrane of mitochondria and plays crucial roles in energy metabolism, apoptosis, and metabolites transport. In plants, the expression of VDACs can be affected by different stresses, including drought, salinity and pathogen defense. In this study, we investigated the expression pattern of AtVDAC2 in A. thaliana and found ABA suppressed the accumulation of AtVDAC2 transcripts. Further, phenotype analysis of this VDAC deregulated-expression transgenic Arabidopsis plants indicated that AtVDAC2 anti-sense line showed an ABA-insensitivity phenotype during the early seedling development under ABA treatment. The results suggested that AtVDAC2 might be involved in ABA signaling in A. thaliana.


ABA signaling; Arabidopsis thaliana; abscisic acid; voltage-dependent anion channel

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