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[Expression and significance of IGF-1R and VEGF in gastric carcinoma].

[Article in Chinese]

Author information

1
Department of Stomach Intestine Surgery in No.1 Peoples Hospital of Huaian, Nanjing Medical University, Huaian 223000, China. lwd1512@yahoo.com.cn

Abstract

AIM:

To analyze the expression of IGF-1R and VEGF in human gastric carcinoma, and evaluate the relationship between their expression and tumor's invasion and metastasis.

METHODS:

56 cases with gastric carcinoma, 20 cases of atypical hyperplasia tissues of adjacent carcinoma and 28 normal gastric mucosa membrane tissues were examined for the expression of IGF-1R and VEGF by SABC immunohistochemistry.

RESULTS:

The positive rates of IGF-1R protein in gastric carcinoma tissues, atypical hyperplasia tissues of adjacent carcinoma and normal gastric mucosa membrane tissues are 87.50%, 55.00% and 17.86%, respectively, and the difference between any two groups was significant (P<0.01); the positive rates of IGF-1R protein in the tissues of metastasis and non-metastasis are 97.06% and 72.73%, respectively(P<0.05); the positive rates of IGF-1R protein in the gastric carcinoma tissues of invaded submucosa, muscular and outer layers are 66.67%, 92.59% and 100%, respectively (P<0.05). The positive rates of VEGF protein in gastric carcinoma tissues, atypical hyperplasia tissues of adjacent carcinoma and normal gastric mucosa are 69.64%, 45.00% and 25.00%, respectively, and the difference between any two groups is significant (P<0.05); the positive rates of VEGF protein in the tissues of metastasis and non-metastasis are 85.29% and 45.45%, respectively (P<0.01); the positive rates of VEGF protein in the gastric carcinoma tissues of invaded submucosa, muscular and outer layers are 40.00%, 74.07% and 85.71%, respectively (P<0.05).

CONCLUSION:

The results suggest that the expression of IGF-1R or VEGF may be related to the development, invasion and metastasis of gastric carcinoma.

PMID:
19500509
[Indexed for MEDLINE]

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