Format

Send to

Choose Destination
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Apr;29(4):729-31.

[Determination of the concentrations of interleukin-18 and other cytokines in the synovial fluid in patients with osteoarthritis].

[Article in Chinese]

Author information

1
Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Abstract

OBJECTIVE:

To determine the concentrations of interleukin-18 (IL-18), IL-6, IL-8, and prostaglandin E2 (PGE2) in the synovial fluid in patients with osteoarthritis (OA), and explore the role of IL-18 in the pathogenesis of OA.

METHODS:

The synovial fluid was collected from 30 patients with knee OA, and the concentrations of IL-18 and the other cytokines were measured using enzyme-linked immunosorbent assay (ELISA). A linear regression was performed between IL-18 and the other cytokines.

RESULTS:

The average IL-18 and PGE2 concentrations were 220-/+304 pg/ml and 89-/+104 pg/ml in the synovial fluid, respectively, and the two cytokines showed a positive correlation in the synovial fluid (r=0.628, P=0.001). The IL-18 concentration was also correlated to the concentrations of IL-6 (1200-/+1587 pg/ml, n=22; r=0.590, P=0.008) and IL-8 (5190-/+6024 pg/ml, n=9; r=0.776, P=0.014).

CONCLUSION:

IL-18 can promote PGE2 production, which causes cartilage degradation in OA, thus therapies targeting this cytokine may prove an effective approach to early OA treatment.

PMID:
19403407
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center