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J Rheumatol. 2009 Feb;36(2):295-7. doi: 10.3899/jrheum.080503.

Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors.

Author information

1
Department of Clinical Medicine and Rheumatology, University "Campus Bio-Medico" of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy.

Abstract

OBJECTIVE:

To study concentrations of adipokines in patients with systemic lupus erythematosus (SLE) and the relationship among adipokines, the metabolic syndrome (MeS), and cardiovascular disease (CVD) risk factors.

METHODS:

We enrolled 50 SLE patients and 26 controls, all women. Leptin, resistin, visfatin, and adiponectin were measured by commercial ELISA kits.

RESULTS:

MeS prevalence was increased among subjects with SLE. Leptin levels were higher in patients with SLE than controls. Among SLE patients, independent determinants of leptin were insulin levels (p < 0.0001), triglycerides (p = 0.03), body mass index (p = 0.02), corticosteroid dosage (p = 0.02), and SLE Disease Activity Index (p = 0.005). Other adipokines did not differ between SLE patients and controls.

CONCLUSION:

Leptin was increased in SLE patients and could play a role in SLE-related cardiovascular diseases.

PMID:
19132788
DOI:
10.3899/jrheum.080503
[Indexed for MEDLINE]

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