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Thromb Haemost. 2008 Dec;100(6):969-75.

Regulation of plasminogen activator inhibitor type 1 gene expression by inflammatory mediators and statins.

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Division of Angiology and Hemostasis, University Hospital of Geneva, 24, Rue Micheli-du-Crest, 1211 Geneva, Switzerland.


Elevated plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1), also named serpin E1, are encountered in patients with thrombophilia, atherosclerosis, septicemia and the metabolic syndrome and may be associated with an increased risk of complications. Expression of PAI-1 is increased by inflammatory stimuli and decreased by statins, drugs widely used in patients with cardiovascular disease. Increased expression of PAI-1 by inflammatory stimuli is mediated by a large variety of signal transduction pathways, which include the NF-kappaB and MAP kinase pathways. The downregulating effect of statins on PAI-1 expression is dependent on the inhibition of Rho family proteins and may involve an activation of PI-3 kinase/Akt signaling pathways. In this review we summarize the findings on the effect of inflammation and statins on PAI-1 expression.

[Indexed for MEDLINE]

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