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Neurosci Lett. 2007 Apr 12;416(2):180-3. Epub 2007 Feb 7.

ABCA1 polymorphisms and Alzheimer's disease.

Author information

1
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda, MD 20892-3707, USA. wavrant@mail.nih.gov

Abstract

In our search for genetic factors related to the development of Alzheimer's disease, we have genotyped 332 pedigrees for three coding polymorphisms in the ABCA1 gene, two of which are known to alter plasma cholesterol levels, as well as a non-coding polymorphism within the promoter. We show an apparent weak association of rs2230806 (p-value=0.01) with the disease in a sibpair series of Alzheimer's disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps.

PMID:
17324514
PMCID:
PMC1945126
DOI:
10.1016/j.neulet.2007.02.010
[Indexed for MEDLINE]
Free PMC Article

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