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J Atheroscler Thromb. 2006 Aug;13(4):175-82.

Impact of C-reactive protein on the likelihood of carotid atherosclerosis in Japanese adults.

Author information

1
Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime, Japan. rykawamo@ehime.med.or.jp

Abstract

OBJECTIVE:

Several cohort studies have shown a link between serum C-reactive protein (CRP) and subsequent cardiovascular disease; however, the role of CRP as an independent risk factor remains controversial. We therefore investigated the association between CRP and sclerotic lesions of common carotid atherosclerosis.

PATIENTS AND METHODS:

We evaluated sclerotic lesions of common carotid arterial intima-media thickness (IMT) by ultrasonography in 139 men aged 67 +/- 15 years and 201 women aged 75 +/- 10 years. To investigate the relation between CRP and various confounding factors, subjects were divided into four groups based on the quartile of CPR.

RESULTS:

Carotid IMT values were significantly higher in groups with higher CRP (p = 0.022). To identify the possible CRP level and risk factor interactions for IMT, multiple regression analysis for IMT was performed based on risk factors in subjects with a specific CRP level. It was shown that age, smoking status, systolic blood pressure (SBP) and LDL cholesterol were significantly associated with IMT in subjects in the lower CRP groups (CRP-1 approximately CRP-3), and age, SBP and presence of diabetes mellitus in the highest CRP group (CRP-4). To further investigate whether the interaction between CRP and conventional risk factors could influence IMT, a general linear model demonstrated that interaction between CRP and the presence of diabetes mellitus (F = 4.754 p = 0.030) was significantly associated with IMT, in addition to sex, age, SBP, antihypertensive drug use, LDL cholesterol and HDL cholesterol.

CONCLUSIONS:

This finding indicates that the association between CRP and IMT significantly differed between subjects with and without diabetes mellitus.

PMID:
16908949
DOI:
10.5551/jat.13.175
[Indexed for MEDLINE]
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