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Orthopade. 2005 Jul;34(7):645-51.

[Obesity and osteoporosis].

[Article in German]

Author information

1
Reha-Klinik Aukammtal, Wiesbaden. h.friebe@rmkliniken.de

Abstract

Atherosclerosis is a chronic inflammatory disease associated with an elevation of inflammatory markers such as CRP -- a robust predictor of cardiovascular events. Inflammation also plays a pivotal role in the pathogenesis of osteoporosis. IL-6 proved to be the most important predictor of bone loss in the proximal femur. Adipocyte-produced inflammatory cytokines are the pathogenetic link between obesity and its metabolic consequences. The different components of the metabolic syndrome are at the same time well-established risk factors for osteoporosis. Physical training, weight loss, and a Mediterranean-style diet all have a proven cytokine-lowering effect. Contrary to muscle mass, adipose tissue if at all contributes only marginally to the preservation of bone. As a consequence, increasing lean body mass while reducing fat mass seems to be the most effective way to prevent both atherosclerosis and osteoporosis.

PMID:
15912326
DOI:
10.1007/s00132-005-0821-x
[Indexed for MEDLINE]

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