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Di Yi Jun Yi Da Xue Xue Bao. 2004 Apr;24(4):371-4.

[Gln192Arg polymorphism of the paraoxonase-1 gene is not associated with Alzheimer's disease in Chinese].

[Article in Chinese]

Author information

1
Department of Medical Genetics and Division of Human Morbid Genomics, Key Laboratory of Biotherapy of Human Diseases of the Ministry of Education, West China Hospital, Sichuan University, Chengdu 610041, China. shiand98@21cn.com

Abstract

OBJECTIVE:

To explore the relationship between paraoxonase-1 (PON1) gene Gln192Arg polymorphism and sporadic Alzheimer's disease (AD) in Chinese.

METHODS:

A total of 165 AD patients and 174 age-matched control subjects were enrolled in this study for examination of PON1 Gln192Arg and apolipoprotein E gene polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS:

The distribution of PON1 allelic and genotypic frequencies did not significantly differ between AD patients and the control subjects, even after the stratification by ApoE-epsilon4 status.

CONCLUSION:

Gln192Arg polymorphism of the PON1 gene is not associated with sporadic AD in Chinese.

PMID:
15090300
[Indexed for MEDLINE]

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