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Clin Chim Acta. 2003 Oct;336(1-2):83-7.

Nitric oxide production is increased in patients with rheumatoid arthritis but does not correlate with laboratory parameters of disease activity.

Author information

1
Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea. jwchoi@inha.ac.kr

Abstract

BACKGROUND:

To investigate whether nitric oxide (NO) production correlates with laboratory parameters of disease activity in patients with rheumatoid arthritis (RA), we measured serum nitrates and nitrites (NOx) concentrations, rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum iron markers in 115 RA patients.

METHODS:

Serum NOx concentrations were determined after reduction of nitrates to nitrites using the Griess reaction. Serum transferrin receptor (sTfR) and serum ferritin were assayed using an enzyme immunoassay and a chemiluminescence method. Correlation coefficients of CRP, ESR, and RF vs. NOx concentrations were assessed.

RESULTS:

Serum NOx concentrations averaged 208.3+/-126.8 micromol/l in RA patients without iron deficiency (n=72) and 267.9+/-148.4 micromol/l in RA patients with iron deficiency (n=43), which were significantly higher than those of healthy controls (32.7+/-14.3 micromol/l, p<0.01, respectively). There were no significant differences in mean NOx concentrations between the patients with CRP<0.7 mg/dl and with CRP>/=3.0 mg/dl, nor between the patients with ESR<15.0 mm/h and with ESR>/=40.0 mm/h. Serum NOx concentrations showed no significant correlations with CRP, ESR, and RF but exhibited an inverse correlation with serum iron markers.

CONCLUSION:

NO production markedly increases in patients with RA; however, serum NOx concentration does not seem to be associated with disease activity of RA, at least on the basis of laboratory data of CRP, ESR, and RF.

PMID:
14500038
DOI:
10.1016/s0009-8981(03)00324-3
[Indexed for MEDLINE]

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