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J Invest Dermatol. 1992 Jun;98(6 Suppl):82S-85S.

Excess insulin binding to insulin-like growth factor receptors: proposed mechanism for acanthosis nigricans.

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Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235.


Clinical and epidemiologic evidence has shown acanthosis nigricans to be closely related to defective tissue utilization of insulin in a number of previously recognized (e.g., obesity, lipodystrophy, and leprechaunism) as well as recently characterized (e.g., type A and type B syndromes) disorders. This article reviews the relationship of acanthosis nigricans to these insulin-resistant states. It also focuses attention on the possibility that interaction between excessive amounts of circulating insulin with insulin-like growth factor receptors on keratinocytes and dermal fibroblasts leads to the development of acanthosis nigricans.

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