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J Invest Dermatol. 1992 Jun;98(6 Suppl):82S-85S.

Excess insulin binding to insulin-like growth factor receptors: proposed mechanism for acanthosis nigricans.

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1
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235.

Abstract

Clinical and epidemiologic evidence has shown acanthosis nigricans to be closely related to defective tissue utilization of insulin in a number of previously recognized (e.g., obesity, lipodystrophy, and leprechaunism) as well as recently characterized (e.g., type A and type B syndromes) disorders. This article reviews the relationship of acanthosis nigricans to these insulin-resistant states. It also focuses attention on the possibility that interaction between excessive amounts of circulating insulin with insulin-like growth factor receptors on keratinocytes and dermal fibroblasts leads to the development of acanthosis nigricans.

PMID:
1316928
DOI:
10.1111/1523-1747.ep12462293
[Indexed for MEDLINE]
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