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Neurology. 2003 May 13;60(9):1525-7.

Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke.

Author information

1
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada. michael.hill@calgaryhealthregion.ca

Abstract

One hundred seventy-six consecutive patients treated with IV tissue plasminogen activator (tPA) for acute ischemic stroke were examined prospectively, and orolingual angioedema was found in nine (5.1%; 95% CI 2.3 to 9.5). The reaction was typically mild, transient, and contralateral to the ischemic hemisphere. Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0).

[Indexed for MEDLINE]

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