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Semin Thromb Hemost. 2000;26(5):495-501.

Impaired endogenous fibrinolysis in diabetes mellitus: mechanisms and therapeutic approaches.

Author information

1
Department of Cardiology, University of Freiburg, Germany. nordt@mm31.ukl.uni-freiburg.de

Abstract

In type II diabetes mellitus the activity of the endogenous fibrinolytic system is reduced secondary to increased plasma activity of the plasminogen activator inhibitor type 1 (PAI-1). Because PAI-1 is considered an independent risk factor for cardiovascular disease, increased PAI-1 activity in diabetes mellitus may partly explain the increased susceptibility to both primary atherosclerosis and restenosis after angioplasty in this disease. The factors contributing to increased PAI-1 expression in diabetes mellitus are reviewed as well as possible therapeutic approaches to normalize increased PAI-1 expression.

PMID:
11129405
DOI:
10.1055/s-2000-13205
[Indexed for MEDLINE]

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