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Items: 1 to 20 of 474

1.

Accurate analysis of genuine CRISPR editing events with ampliCan.

Labun K, Guo X, Chavez A, Church G, Gagnon JA, Valen E.

Genome Res. 2019 Mar 8. pii: gr.244293.118. doi: 10.1101/gr.244293.118. [Epub ahead of print]

2.

Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium.

Zoltick ES, Linderman MD, McGinniss MA, Ramos E, Ball MP, Church GM, Leonard DGB, Pereira S, McGuire AL, Caskey CT, Sanderson SC, Schadt EE, Nielsen DE, Crawford SD, Green RC; PeopleSeq Consortium.

Genome Med. 2019 Feb 27;11(1):10. doi: 10.1186/s13073-019-0619-9.

3.

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.

Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA.

Cell Rep. 2019 Jan 29;26(5):1112-1127.e9. doi: 10.1016/j.celrep.2019.01.023.

4.

Significant abundance of cis configurations of coding variants in diploid human genomes.

Hoehe MR, Herwig R, Mao Q, Peters BA, Drmanac R, Church GM, Huebsch T.

Nucleic Acids Res. 2019 Jan 30. doi: 10.1093/nar/gkz031. [Epub ahead of print]

PMID:
30698752
5.

Crystal structure of the Redβ C-terminal domain in complex with λ Exonuclease reveals an unexpected homology with λ Orf and an interaction with Escherichia coli single stranded DNA binding protein.

Caldwell BJ, Zakharova E, Filsinger GT, Wannier TM, Hempfling JP, Chun-Der L, Pei D, Church GM, Bell CE.

Nucleic Acids Res. 2019 Feb 28;47(4):1950-1963. doi: 10.1093/nar/gky1309.

6.

CRISPR-C: circularization of genes and chromosome by CRISPR in human cells.

Møller HD, Lin L, Xiang X, Petersen TS, Huang J, Yang L, Kjeldsen E, Jensen UB, Zhang X, Liu X, Xu X, Wang J, Yang H, Church GM, Bolund L, Regenberg B, Luo Y.

Nucleic Acids Res. 2018 Dec 14;46(22):e131. doi: 10.1093/nar/gky767.

7.

Opinion: Advocating for science progress as a human right.

Porsdam Mann S, Donders Y, Mitchell C, Bradley VJ, Chou MF, Mann M, Church G, Porsdam H.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10820-10823. doi: 10.1073/pnas.1816320115. No abstract available.

8.

CRISPR Guide RNA Cloning for Mammalian Systems.

Nageshwaran S, Chavez A, Cher Yeo N, Guo X, Lance-Byrne A, Tung A, Collins JJ, Church GM.

J Vis Exp. 2018 Oct 2;(140). doi: 10.3791/57998.

PMID:
30346403
9.

Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow.

Brunk E, Chang RL, Xia J, Hefzi H, Yurkovich JT, Kim D, Buckmiller E, Wang HH, Cho BK, Yang C, Palsson BO, Church GM, Lewis NE.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11096-11101. doi: 10.1073/pnas.1811971115. Epub 2018 Oct 9.

PMID:
30301795
10.

Establishing a Cell-Free Vibrio natriegens Expression System.

Wiegand DJ, Lee HH, Ostrov N, Church GM.

ACS Synth Biol. 2018 Oct 19;7(10):2475-2479. doi: 10.1021/acssynbio.8b00222. Epub 2018 Sep 12.

PMID:
30160938
11.

Developmental barcoding of whole mouse via homing CRISPR.

Kalhor R, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, Church GM.

Science. 2018 Aug 31;361(6405). pii: eaat9804. doi: 10.1126/science.aat9804. Epub 2018 Aug 9.

12.

Inter-homologue repair in fertilized human eggs?

Egli D, Zuccaro MV, Kosicki M, Church GM, Bradley A, Jasin M.

Nature. 2018 Aug;560(7717):E5-E7. doi: 10.1038/s41586-018-0379-5. Epub 2018 Aug 8. No abstract available.

PMID:
30089924
13.

Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators.

Juárez JF, Lecube-Azpeitia B, Brown SL, Johnston CD, Church GM.

Nat Commun. 2018 Aug 6;9(1):3101. doi: 10.1038/s41467-018-05525-6.

14.

An enhanced CRISPR repressor for targeted mammalian gene regulation.

Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM.

Nat Methods. 2018 Aug;15(8):611-616. doi: 10.1038/s41592-018-0048-5. Epub 2018 Jul 16.

15.

Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.

Musah S, Dimitrakakis N, Camacho DM, Church GM, Ingber DE.

Nat Protoc. 2018 Jul;13(7):1662-1685. doi: 10.1038/s41596-018-0007-8.

PMID:
29995874
16.

Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.

Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ.

Mol Cell. 2018 Jul 5;71(1):42-55.e8. doi: 10.1016/j.molcel.2018.06.005.

PMID:
29979968
17.

Characterizing Protein Kinase Substrate Specificity Using the Proteomic Peptide Library (ProPeL) Approach.

Lubner JM, Balsbaugh JL, Church GM, Chou MF, Schwartz D.

Curr Protoc Chem Biol. 2018 Jun;10(2):e38. doi: 10.1002/cpch.38.

PMID:
29927115
18.

Review of Scientific Self-Experimentation: Ethics History, Regulation, Scenarios, and Views Among Ethics Committees and Prominent Scientists.

Hanley BP, Bains W, Church G.

Rejuvenation Res. 2019 Feb;22(1):31-42. doi: 10.1089/rej.2018.2059. Epub 2018 Aug 8. Review.

PMID:
29926769
19.

Current CRISPR gene drive systems are likely to be highly invasive in wild populations.

Noble C, Adlam B, Church GM, Esvelt KM, Nowak MA.

Elife. 2018 Jun 19;7. pii: e33423. doi: 10.7554/eLife.33423.

20.

Building Capacity for a Global Genome Editing Observatory: Institutional Design.

Saha K, Hurlbut JB, Jasanoff S, Ahmed A, Appiah A, Bartholet E, Baylis F, Bennett G, Church G, Cohen IG, Daley G, Finneran K, Hurlbut W, Jaenisch R, Lwoff L, Kimes JP, Mills P, Moses J, Park BS, Parens E, Salzman R, Saxena A, Simmet H, Simoncelli T, Snead OC, Rajan KS, Truog RD, Williams P, Woopen C.

Trends Biotechnol. 2018 Aug;36(8):741-743. doi: 10.1016/j.tibtech.2018.04.008. Epub 2018 Jun 8.

PMID:
29891181

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